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17,972 results
  • Reversible Splenial Lesion Syndrome with Some Novel Causes and Clinical Manifestations. [Journal Article]
    Intern Med. 2020 Jun 30 [Online ahead of print]Lu PL, Hodes JF, … Hu XY
  • Objective Reversible Splenial Lesion Syndrome (RESLES) is a clinical radiological syndrome characterized by a reversible lesion of the splenium of the corpus callosum with a decreased apparent diffusion coefficient (ADC) value. The clinical manifestations of RESLES are diverse. Methods Fifteen cases of adult RESLES patients (10 males and 5 females) were retrospectively selected from the radiology…
  • The Role of Clozapine as a Mood Regulator in the Treatment of Rapid Cycling Bipolar Affective Disorder. [Journal Article]
    Turk Psikiyatri Derg. 2019 Winter; 30(4):268-271.Kılınçel O, Kılınçel Ş, … Akkaya C
  • CONCLUSIONS: In this study, it was determined that clozapine was effective as a mood stabilizer in Bipolar Affective Disorder treatment. The results show that clozapine reduces the episode frequency and the duration in rapid cycling Bipolar Affective Disorder which does not respond to all conventional treatments, including lithium, valproic acid, carbamazepine and antipsychotic drugs.
  • Recent advances in managing and understanding Stevens-Johnson syndrome and toxic epidermal necrolysis. [Review]
    F1000Res. 2020; 9Hasegawa A, Abe R
  • Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases characterized by detachment of the epidermis and mucous membrane. SJS/TEN are considered to be on the same spectrum of diseases with different severities. They are classified by the percentage of skin detachment area. SJS/TEN can also cause several complications in the liver, kidneys, and respiratory…
  • Non-dystrophic myotonia Chilean cohort with predominance of the SCN4A Gly1306Glu variant. [Journal Article]
    Neuromuscul Disord. 2020 May 19 [Online ahead of print]Avila-Smirnow D, Vargas Leal CP, … Sternberg D
  • Non-dystrophic myotonias are a group of rare neuromuscular diseases linked to SCN4A or CLCN1. Among the subtypes, myotonia permanens, associated with the Gly1306Glu variant of SCN4A, is a relatively less frequent but more severe form. Most reports of non-dystrophic myotonias describe European populations. Therefore, to expand the genetic and phenotypic spectrum of this disorder, we evaluated 30 C…
  • Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. [Journal Article]
    Neuropharmacology. 2004 Jun; 46(8):1097-1104.Kaminski RM, Banerjee M, Rogawski MA
  • Although the mechanism of action of topiramate is not fully understood, its anticonvulsant properties may result, at least in part, from an interaction with AMPA/kainate receptors. We have recently shown that topiramate selectively inhibits postsynaptic responses mediated by GluR5 kainate receptors. To determine if this action of topiramate is relevant to the anticonvulsant effects of the drug in…
  • Ion Channel Contributions to Morphological Development: Insights From the Role of Kir2.1 in Bone Development. [Review]
    Front Mol Neurosci. 2020; 13:99.Ozekin YH, Isner T, Bates EA
  • The role of ion channels in neurons and muscles has been well characterized. However, recent work has demonstrated both the presence and necessity of ion channels in diverse cell types for morphological development. For example, mutations that disrupt ion channels give rise to abnormal structural development in species of flies, frogs, fish, mice, and humans. Furthermore, medications and recreati…
  • Removal of pharmaceuticals from nitrified urine by adsorption on granular activated carbon. [Journal Article]
    Water Res X. 2020 Dec 01; 9:100057.Köpping I, McArdell CS, … Udert KM
  • Nitrification and distillation of urine allow for the recovery of all nutrients in a highly concentrated fertilizer solution. However, pharmaceuticals excreted with urine are only partially removed during these two process steps. For a sustainable and safe application, more extensive removal of pharmaceuticals is necessary. To enhance the pharmaceutical removal, which is already occurring during …
  • Eslicarbazepine for focal epilepsy and acute intermittent porphyria. [Journal Article]
    Epileptic Disord. 2020 Jun 01; 22(3):349-352.Herrera-Fortin T, Pana R, … Nguyen DK
  • Porphyrias are rare genetic disorders which cause a deficiency in the enzymes involved in the biosynthesis of heme. The treatment of epilepsy in patients with acute intermittent porphyria can be difficult since many anticonvulsants can increase heme synthesis and trigger porphyric attacks. We report a patient with focal epilepsy successfully treated with eslicarbazepine without exacerbation of po…
  • Familial Hemiplegic Migraine with an ATP1A4 Mutation: Clinical Spectrum and Carbamazepine Efficacy. [Case Reports]
    Brain Sci. 2020 Jun 15; 10(6)Coppola G, Pastorino GMG, … Operto FF
  • An Italian family with familial hemiplegic migraine (FHM) with the absence of mutations in the known genes associated with this disorder, namely ATP1A2, ATP1A3, CACNA1A, and SCN1A, has recently been reported. Soon afterward, whole exome sequencing allowed the identification of the carrier status of a heterozygous ATP1A4 mutation c.1798 C >T, in four affected members of this family. Here we compar…
  • Occurrence of pharmaceuticals in the Danube and drinking water wells: Efficiency of riverbank filtration. [Journal Article]
    Environ Pollut. 2020 Jun 08; 265(Pt A):114893.Kondor AC, Jakab G, … Szalai Z
  • Surface waters are becoming increasingly contaminated by pharmaceutically active compounds (PhACs), which is a potential risk factor for drinking water quality owing to incomplete riverbank filtration. This study examined the efficiency of riverbank filtration with regard to 111 PhACs in a highly urbanized section of the river Danube. One hundred seven samples from the Danube were compared to 90 …
  • Oxaliplatin-induced peripheral neuropathy risk factors and management in Tunisian population. [Case Reports]
    Pan Afr Med J. 2020; 35:83.Zribi A, Nasr SB, … Haddaoui A
  • The most important limits of oxaliplatin treatment is its peripheral neurotoxicity. The aim of our study was to evaluate the oxaliplatin-induced peripheral neuropathy, its impact on treatment and its management. One hundred chemo-naive patients treated with oxaliplatin-based regimen in the medical oncology department of the military hospital of Tunis between 2012 and 2017 were recruited retrospec…
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