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17,480 results
  • Hepatic Bioactivation of Skin-Sensitizing Drugs to Immunogenic Reactive Metabolites. [Journal Article]
    ACS Omega 2019; 4(9):13902-13912Chong LH, Ng C, … Toh YC
  • The clinical use of some drugs, such as carbamazepine, phenytoin, and allopurinol, is often associated with adverse cutaneous reactions. The bioactivation of drugs into immunologically reactive metabolites by the liver is postulated to be the first step in initiating a downstream cascade of pathological immune responses. Current mechanistic understanding and the ability to predict such adverse dr…
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