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(carbacephem)
63 results
  • Different antibiotic treatments for group A streptococcal pharyngitis. [Review]
    Cochrane Database Syst Rev 2016; 9:CD004406van Driel ML, De Sutter AI, … Christiaens T
  • CONCLUSIONS: There were no clinically relevant differences in symptom resolution when comparing cephalosporins and macrolides with penicillin in the treatment of GABHS tonsillopharyngitis. Limited evidence in adults suggests cephalosporins are more effective than penicillin for relapse, but the NNTB is high. Limited evidence in children suggests carbacephem is more effective than penicillin for symptom resolution. Data on complications are too scarce to draw conclusions. Based on these results and considering the low cost and absence of resistance, penicillin can still be regarded as a first choice treatment for both adults and children. All studies were in high-income countries with low risk of streptococcal complications, so there is need for trials in low-income countries and Aboriginal communities where risk of complications remains high.
  • Kinetic study of the effect of histidines 240 and 164 on TEM-149 enzyme probed by β-lactam inhibitors. [Journal Article]
    Antimicrob Agents Chemother 2014; 58(10):6294-6Perilli M, Mancini A, … Amicosante G
  • In the present study, we performed a detailed kinetic analysis of the enzymes TEM-149, TEM-149(H240), and TEM-149(H164-H240) versus a large panel of inhibitors/inactivators, including penicillins, penems, carbapenems, monobactams, cephamycin, and carbacephem. These compounds behaved as poor substrates versus TEM-149, TEM-149(H240), and TEM-149(H164-H240) β-lactamases, and the Ki (inhibition const…
  • Different antibiotic treatments for group A streptococcal pharyngitis. [Review]
    Cochrane Database Syst Rev 2013; (4):CD004406van Driel ML, De Sutter AI, … Christiaens T
  • CONCLUSIONS: Evidence is insufficient to show clinically meaningful differences between antibiotics for GABHS tonsillopharyngitis. Limited evidence in adults suggests cephalosporins are more effective than penicillin for relapse, but the NNTB is high. Limited evidence in children suggests carbacephem is more effective for symptom resolution. Data on complications are too scarce to draw conclusions. Based on these results and considering the low cost and absence of resistance, penicillin can still be recommended as first choice.
  • Different antibiotic treatments for group A streptococcal pharyngitis. [Review]
    Cochrane Database Syst Rev 2010; (10):CD004406van Driel ML, De Sutter AI, … Christiaens T
  • CONCLUSIONS: Evidence is insufficient for clinically meaningful differences between antibiotics for GABHS tonsillopharyngitis. Limited evidence in adults suggests cephalosporins are more effective than penicillin for relapse, but the NNTB is high. Limited evidence in children suggests carbacephem is more effective for symptom resolution. Data on complications are too scarce to draw conclusions. Based on these results and considering the low cost and absence of resistance, penicillin can still be recommended as first choice.
  • Novel beta-lactam antibiotics synthesized by amination of catechols using fungal laccase. [Journal Article]
    Chem Pharm Bull (Tokyo) 2008; 56(7):902-7Mikolasch A, Wurster M, … Lindequist U
  • Novel cephalosporins, penicillins, and carbacephems were synthesized by amination of catechols with amino-beta-lactams like cefadroxil, amoxicillin, ampicillin and the structurally related carbacephem loracarbef using laccase from Trametes sp. All isolated monoaminated products inhibited the growth of several Gram positive bacterial strains in the agar diffusion assay, among them methicillin-resi…
  • Antimicrobial agents in orthopaedic surgery: Prophylaxis and treatment. [Review]
    Drugs 2006; 66(8):1089-105Trampuz A, Zimmerli W
  • The pathogenesis of implant-associated infection involves interaction between the microorganisms (biofilm formation), the implant and the host. Despite improvement of perioperative prophylaxis, orthopaedic implants still remain highly susceptible to bacterial or fungal contamination, generally resulting in persistent implant-associated infection. Therefore, perioperative and life-long prevention …
  • Using steric hindrance to design new inhibitors of class C beta-lactamases. [Journal Article]
    Chem Biol 2002; 9(9):971-80Trehan I, Morandi F, … Shoichet BK
  • beta-lactamases confer resistance to beta-lactam antibiotics such as penicillins and cephalosporins. However, beta-lactams that form an acyl-intermediate with the enzyme but subsequently are hindered from forming a catalytically competent conformation seem to be inhibitors of beta-lactamases. This inhibition may be imparted by specific groups on the ubiquitous R(1) side chain of beta-lactams, suc…
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