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60,628 results
  • Upstream regulation of the Hippo-Yap pathway in cardiomyocyte regeneration. [Review]
    Semin Cell Dev Biol 2019Flinn MA, Link BA, O'Meara CC
  • The response of the adult mammalian heart to injury such as myocardial infarction has long been described as primarily fibrotic scarring and adverse remodeling with little to no regeneration of cardiomyocytes. Emerging studies have challenged this paradigm by demonstrating that, indeed, adult mammalian cardiomyocytes are capable of completing cytokinesis albeit at levels vastly insufficient to co…
  • The N-termini of GRK2 and GRK3 simulate the stimulating effects of RKIP on β-adrenoceptors. [Journal Article]
    Biochem Biophys Res Commun 2019Maimari T, Krasel C, … Lorenz K
  • The Raf kinase inhibitor protein (RKIP) activates β-adrenoceptors (β-AR) and thereby induces a well-tolerated cardiac contractility and prevents heart failure in mice. Different to RKIP-mediated β-AR activation, chronic activation of β-AR by catecholamines was shown to be detrimental for the heart. RKIP is an endogenous inhibitor of G protein coupled receptor kinase 2 (GRK2); it binds GRK2 and th…
  • Optimising platelet secretomes to deliver robust tissue-specific regeneration. [Journal Article]
    J Tissue Eng Regen Med 2019Scully D, Sfyri P, … Matsakas A
  • Promoting cell proliferation is the cornerstone of most tissue regeneration therapies. As platelet-based applications promote cell division and can be customised for tissue-specific efficacy, this makes them strong candidates for developing novel regenerative therapies. Therefore, the aim of this study was to determine if platelet releasate could be optimised to promote cellular proliferation and…
  • [Fluorescence imaging of the living heart for understanding the basis of arrhythmias]. [Journal Article]
    Nihon Yakurigaku Zasshi 2019; 154(4):171-177Tanaka H
  • Recent outstanding progress in microscopic imaging technology and the advent of fluorescent probes have enabled us to visualize high spatiotemporal dynamics of intracellular molecules in living tissues. Here I introduce our research outcomes on functional fluorescence imaging of the heart especially for understanding the pathogenesis of cardiac arrhythmias. On the in situ Ca2+ imaging of perfused…
  • [The beneficial effects of iron supplementation other than improvement of anemia]. [Journal Article]
    Rinsho Ketsueki 2019; 60(9):1092-1099Hamano T
  • Previous randomized controlled trials (RCTs) have shown beneficial effects of iron supplementation other than anemia improvement including treatment of restless leg syndrome and general fatigue, even in non-anemic subjects with iron deficiency. Recently, some RCTs in congestive heart failure (CHF) demonstrated that intravenous administration of ferric carboxymaltose improves patient symptoms and …
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