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(cardionecrosis)
15 results
  • Myocardial necrosis due to vitamin D3 overdose -- scanning electron microscopic observations. [Journal Article]
    Folia Morphol (Warsz) 2004; 63(4):439-44Walentynowicz O, Kubasik-Juraniec J, Rudzińska-Kisiel T
  • Our studies were carried out on the hearts of virgin female Wistar rats treated with 100,000 i.u. of vitamin D3 (calciol) per os for 3 consecutive days. Multifocal cardionecrosis was established macroscopically in 70% of the vitamin D-treated rats on the 7th day of the experiment when the rats were in the acute phase of intoxication. Using a scanning electron microscopy (SEM), we received three-d…
  • Pathogenesis of heart myofibril lesion in experimental vitamin D-induced cardionecrosis. [Journal Article]
    Exp Mol Pathol 1995; 63(3):200-9Walentynowicz O, Wrzołkowa T
  • Multifocal cardionecrosis has been produced in rats by treatment with 3 x 100,000 iu vitamin D3 (calciol). The effects of hypervitaminosis D on rat heart myofibril structure and total protease activity was investigated. Proteolytic enzyme activity of heart muscle homogenate was determined in two independent ways, and was approximately two times higher in the necrotic heart homogenate than in the …
  • Calcium content of serum and myocardium in vitamin D-induced cardionecrosis. [Journal Article]
    Bone Miner 1991; 13(2):111-21Wrzołkowa T, Rudzińska-Kisiel T, Kłosowska B
  • The dynamics of calcium content alterations in serum and heart muscle in relation to vitamin D-induced cardionecrosis was the aim of the experiment performed on female Wistar rats killed at different times after one or two intraoral doses of 100,000 IU of vitamin D. Calcium concentration in the serum showed great individual variability, although the mean value was significantly elevated after 22 …
  • Effects of ethanol on the development of experimental atherosclerosis and cardionecrosis in rats. [Journal Article]
    Alcohol 1990 Jul-Aug; 7(4):299-306Wrzołkowa T, Rudzińska-Kisiel T
  • The influence of chronic ethanol intoxication upon vitamin D-induced damage of cardiovascular system in rats was examined. Eighty rats, divided into 16 groups according to sex and age, were intoxicated with ethanol as the only source of liquid. Control rats drank water only. After 6 months of ethanol intoxication, part of ethanol and part of water-drinking rats received 3 x 100,000 IU vitamin D/r…
  • Drug-induced cardionecrosis. [Journal Article]
    Arch Toxicol Suppl 1984; 7:1-15Godfraind T
  • Cardiotoxicity may be defined as a drug action producing abnormalities in cardiac function, such as transitory disturbances or rhythm, conduction or contractility. Clearance of the drug is followed by recovery of the initial function. Cardionecrosis is the irreversible consequence of cardiotoxicity. Its appearance depends not only upon the toxicological potency of a given compound but may also de…
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