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18 results
  • Different influences on tacrolimus pharmacokinetics by coadministrations of zhi ke and zhi shi in rats. [Journal Article]
    Evid Based Complement Alternat Med 2011; 2011:751671Lin SP, Wu PP, … Chao PD
  • Tacrolimus, an immunosuppressant with narrow therapeutic window, has been used widely in transplant patients. Grapefruit juice and pomelo have been reported to increase the blood levels of tacrolimus. Zhi Ke and Zhi Shi, the ripe peels and unripe fruits of Citrus aurantium which is chemotaxonomically related to grapefruit and pomelo, are in wide use in clinical Chinese medicine. To investigate th…
  • Indoxyl sulfate, a uremic toxin, is biotransformed from indoxyl-beta-D-glucoside (indican) in rats. [Journal Article]
    Toxicon 2008; 52(3):440-4Hou YC, Tsai SY, … Chao PD
  • Indican (Indoxyl-beta-D-glucoside) is present in many Chinese herbs such as Isatis indigotica, Clerodendrum crytophyllum, Glehnia littoralis, Polygonum tinctorium and P. perfoliatum. This study aims to investigate whether indoxyl sulfate, a uremic toxin, would be biotransformed from indican in rats. Indican was administered intravenously and orally to Sprague-Dawley rats. The blood samples were w…
  • Metabolism and pharmacokinetics of genipin and geniposide in rats. [Journal Article]
    Food Chem Toxicol 2008; 46(8):2764-9Hou YC, Tsai SY, … Chao PD
  • Geniposide, an iridoid glucoside, is a major constituent in the fruits of Gardenia jasminoides (Gardenia fruits), a popular Chinese herb. Genipin, the aglycone of geniposide, is used to prepare blue colorants in food industry and also a crosslinking reagent for biological tissue fixation. In this study, we investigated the metabolism and pharmacokinetics of genipin and geniposide in rats. Blood s…
  • Ginger significantly decreased the oral bioavailability of cyclosporine in rats. [Journal Article]
    Am J Chin Med 2006; 34(5):845-55Chiang HM, Chao PD, … Hou YC
  • Ginger (roots of Zingiber officinale ROSCOE) is a popular spice and herbal medicine worldwide. Cyclosporine is clinically used as an important immunosupressant with narrow therapeutic index. This study attempted to investigate the effect of ginger juice on the pharmacokinetics of cyclosporine in rats. Rats were orally administered cyclosporine alone and in combination with ginger juice (5 ml/kg) …
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