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2,576 results
  • Pembrolizumab in men with heavily treated metastatic castrate-resistant prostate cancer. [Journal Article]
  • CMCancer Med 2019 Jul 03
  • Tucker MD, Zhu J, … Armstrong AJ
  • CONCLUSIONS: In a heavily pretreated population of men with mCRPC, pembrolizumab was associated with a ≥50% PSA decline in 17% (8/48) of men, including a dramatic ≥90% PSA response in 8% (4/48), two of whom harbored pathogenic LRP1b mutations suggesting that LRP1b mutations may enrich for PD-1 inhibitor responsiveness in prostate cancer.
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