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134 results
  • RNA: interactions drive functionalities. [Review]
    Mol Biol Rep 2020; 47(2):1413-1434Dai X, Zhang S, Zaleta-Rivera K
  • RNA is produced from the majority of human genomic sequences, although only a relatively small portion of these transcripts has known functions. Diverse RNA species interact with RNA, DNA, proteins, lipids, and metabolites to form intricate molecular networks. In this review, we attempt to delineate diverse RNA functions by interaction types between RNA and other macromolecules. Through such inte…
  • Diclofenac Potentiates Sorafenib-Based Treatments of Hepatocellular Carcinoma by Enhancing Oxidative Stress. [Journal Article]
    Cancers (Basel) 2019; 11(10)Duval AP, Troquier L, … Dormond O
  • Sorafenib is the first developed systemic treatment for advanced forms of hepatocellular carcinoma, which constitutes the most frequent form of primary liver cancers and is a major global health burden. Although statistically significant, the positive effect of sorafenib on median survival remains modest, highlighting the need to develop novel therapeutic approaches. In this report, we introduce …
  • Isoproterenol enhances force production in mouse glycolytic and oxidative muscle via separate mechanisms. [Journal Article]
    Pflugers Arch 2019; 471(10):1305-1316Blackwood SJ, Katz A
  • Fight or flight is a biologic phenomenon that involves activation of β-adrenoceptors in skeletal muscle. However, how force generation is enhanced through adrenergic activation in different muscle types is not fully understood. We studied the effects of isoproterenol (ISO, β-receptor agonist) on force generation and energy metabolism in isolated mouse soleus (SOL, oxidative) and extensor digitoru…
  • Thiol-click photochemistry for surface functionalization applied to optical biosensing. [Journal Article]
    Anal Chim Acta 2019; 1060:103-113Bañuls MJ, González-Martínez MÁ, … Maquieira Á
  • In the field of biosensing, suitable procedures for efficient probes immobilization are of outmost importance. Here we present different light-based strategies to promote the covalent attachment of thiolated capture probes (oligonucleotides and proteins) on different materials and working formats. One strategy employs epoxylated surfaces and uses the light to accomplish the ring opening by a thio…
  • Construction of an ultrasensitive electrochemiluminescent aptasensor for ractopamine detection. [Journal Article]
    Analyst 2019; 144(8):2550-2555Xiong H, Gao J, … Wang S
  • In this study, an ultrasensitive electrochemiluminescence (ECL) aptasensor based on Ru(bpy)32+-doped silica nanoparticles (Ru@SiO2 NPs) coupled with gold nanoparticles (Au NPs) was developed for the determination of ractopamine (Rac). TPrA is used as the coreactant, the Ru@SiO2 NPs serve as the ECL luminophores, and the Au NPs work as a catalyzer in the redox reaction as well as the carrier that …
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