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783 results
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Cephalosporins [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • The cephalosporins are a family of bactericidal antibiotics structurally related to penicillin which were first derived from the fungus, Cephalosporum acremonium. Their basic structure is similar to penicillin with a thiazolidine and beta-lactam ring, which has a variable side chain. Cephalosporins bind to the penicillin-binding proteins on bacteria and inhibit synthesis of the bacterial cell wal…
  • Synthesis of thiophene derivatives and their anti-microbial, antioxidant, anticorrosion and anticancer activity. [Journal Article]
    BMC Chem 2019; 13(1):54Shah R, Verma PK
  • CONCLUSIONS: Antimicrobial screening results showed that compound S 1 was the most potent antibacterial agent against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Salmonella typhi having MIC value 0.81 µM/ml and compound S 4 also displayed excellent antifungal activity against both Candida albicans and Aspergillus niger (MIC = 0.91 µM/ml) when compared with cefadroxil (antibacterial) and fluconazole (antifungal) as standard drug. The antioxidant screening results indicated that compound S 4 and S 6 exhibited excellent antioxidant activity with IC50 values 48.45 and 45.33 respectively when compared with the ascorbic acid as standard drug. Anticorrosion screening results indicated that compound S 7 showed more anticorrosion efficiency (97.90%) with low corrosion rate. Results of anticancer screening indicated that compound S 8 showed effective cytotoxic activity against human lung cancer cell line (A-549) at dose of 10-4 M when compared with adriamycin as standard.
  • Optimized Photoelectrochemical Detection of Essential Drugs Bearing Phenolic Groups. [Journal Article]
    Anal Chem 2019; 91(15):9962-9969Neven L, Shanmugam ST, … De Wael K
  • The World Health Organization (WHO) model "List of Essential Medicines" includes among indispensable medicines antibacterials and pain and migraine relievers. Monitoring their concentration in the environment, while challenging, is important in the context of antibiotic resistance as well as their production of highly toxic compounds via hydrolysis. Traditional detection methods such as high-perf…
  • Chemometrics for resolving spectral data of cephalosporines and tracing their residue in waste water samples. [Journal Article]
    Spectrochim Acta A Mol Biomol Spectrosc 2019; 219:436-443Yehia AM, Elbalkiny HT, … Elsaharty YS
  • Chemometrics approaches have been used in this work to trace cephalosporins in aquatic system. Principal component regression (PCR), partial least squares (PLS), multivariate curve resolution-alternating least squares (MCR-ALS), and artificial neural networks (ANN) were compared to resolve the severally overlapped spectrum of three selected cephalosporins; cefprozil, cefradine and cefadroxil. The…
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