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804 results
  • Antibiotic prophylaxis for operative vaginal delivery. [Review]
    Cochrane Database Syst Rev. 2020 03 26; 3:CD004455.Liabsuetrakul T, Choobun T, … Islam QM
  • CONCLUSIONS: Prophylactic intravenous antibiotics are effective in reducing infectious puerperal morbidities in terms of superficial and deep perineal wound infection or serious infectious complications in women undergoing operative vaginal deliveries without clinical indications for antibiotic administration after delivery. Prophylactic antibiotics slightly improve perineal pain and health consequences of perineal pain, probably reduce the costs, and may slightly reduce the maternal hospital re-admission and health-related quality of life. However, the effect on reduction of endometritis, organ or space perineal wound infection, maternal adverse reactions and maternal length of stay is unclear due to low-certainty evidence. As the evidence was mainly derived from a single multi-centre study conducted in a high-income setting, future well-designed randomised trials in other settings, particularly in low- and middle-income settings, are required to confirm the effect of antibiotic prophylaxis for operative vaginal delivery.
  • Pediatric Prehospital Wound Prophylaxis in Iraq and Afghanistan. [Journal Article]
    Mil Med. 2020 01 07; 185(Suppl 1):73-76.Naylor JF, April MD, … Schauer SG
  • CONCLUSIONS: The most frequently administered antibiotics were cephalosporins. TCCC recommended agents for adult prehospital wound prophylaxis were infrequently administered to pediatric casualties. Administration rates of pediatric prehospital wound prophylaxis may be improved with pediatric-specific TCCC guidelines recommending cephalosporins as first-line agents, fielding of a TCCC-oriented Broselow tape, and training prehospital providers on administration of antimicrobials.
  • The Association Between Cephalosporin and Hypoprothrombinemia: A Systematic Review and Meta-Analysis. [Meta-Analysis]
    Int J Environ Res Public Health. 2019 10 16; 16(20)Park GH, Kim S, … Lee E
  • Cephalosporins that contain the N-methylthiotetrazole side chain (NMTT-cephalosporin) have been reported to be associated with coagulation-related adverse events; however, a comprehensive evaluation regarding the association is lacking. A systematic review and meta-analysis were conducted to assess the safety profile of NMTT-cephalosporins with respect to hypoprothrombinemia and bleeding. The MED…
  • Opioid analgesics are the leading cause of adverse drug reactions in the obstetric population in South Korea. [Journal Article]
    Medicine (Baltimore). 2019 May; 98(21):e15756.Choi SK, Kim YH, … Park IY
  • Medication use during pregnancy is gradually increasing; however, the safety of this practice remains largely unknown.We investigated medications with the most adverse drug reactions (ADRs) among pregnant women and the clinical features of those medications.Reports of ADRs among pregnant women were extracted from the Korea Adverse Events Reporting System (January 2012-December 2015). We analyzed …
  • Maternal anaphylactic shock in pregnancy: A case report. [Case Reports]
    Medicine (Baltimore). 2018 Sep; 97(37):e12351.Jeon HJ, Ryu A, … Kim NS
  • CONCLUSIONS: This is the first reported case of anaphylaxis following cefotetan administration in pregnancy. Cefotetan, a second-generation cephalosporin, is a commonly prescribed antibiotic used to treat a wide range of bacterial infections. The case demonstrated life-threatening anaphylactic reaction during pregnancy. Even a skin test using antibiotics alone triggered anaphylaxis.
  • Cefotetan-Induced Hemolytic Anemia: Case Series and Review. [Case Reports]
    J Pharm Pract. 2019 Dec; 32(6):679-682.Lim K, Tran H, … Klapper E
  • CONCLUSIONS: DIIHA may be difficult to distinguish from other causes of hemolytic anemia, but should be included in the differential in patients exposed to medications associated with DIIHA. Once suspected, antibody testing should be performed, and once diagnosed, further exposure should be avoided.
  • Molecular basis of quinolone resistance in clinical isolates of Klebsiella pneumoniae from Pakistan. [Journal Article]
    Pak J Pharm Sci. 2018 Jul; 31(4(Supplementary)):1591-1596.Alvi RF, Aslam B, … Shafique M
  • Antibiotic resistant Klebsiella pneumoniae, is associated with various nosocomial infections that are difficult to treat. This study is designed to find out the patterns of resistance against commonly used antibiotics in K. pneumoniae clinical isolates with special attention to fluoroquinolones. A total number of 200 K. pneumoniae clinical isolates collected from various tertiary care hospitals o…
  • Drugs and Lactation Database (LactMed): Cefotetan [BOOK]
    . National Library of Medicine (US): Bethesda (MD)BOOK
  • A moderate amount of information indicates that cefotetan produces low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush have been reported with cephalosporins, but these effects have not been adequately evaluated. Cefotetan is acceptable in nursing mothers.
  • Possible Probiotic Lactic Acid Bacteria Isolated from Oysters (Crassostrea gigas). [Journal Article]
    Probiotics Antimicrob Proteins. 2018 12; 10(4):728-739.Kang CH, Gu T, So JS
  • We attempted to isolate lactic acid bacteria (LAB) from the marine oyster (Crassostrea gigas) and selected several environmental stress-resistant isolates for the development of a future probiotic adjuvant for marine aquaculture. Twenty-six presumptive LAB isolates were extracted from oysters and screened (by an agar diffusion assay) for antimicrobial activity toward various pathogens: Vibrio par…
  • Antibiotic prophylaxis for operative vaginal delivery. [Review]
    Cochrane Database Syst Rev. 2017 08 05; 8:CD004455.Liabsuetrakul T, Choobun T, … Islam QM
  • CONCLUSIONS: One small trial was identified reporting only two outcomes. Evidence from this single trial suggests that antibiotic prophylaxis may lead to little or no difference in endometritis or maternal length of stay. There were no data on any other outcomes to evaluate the impact of antibiotic prophylaxis after operative vaginal delivery. Future research on antibiotic prophylaxis for operative vaginal delivery is needed to conclude whether it is useful for reducing postpartum morbidity.
  • Characteristics of Antibiotic Prophylaxis and Risk of Surgical Site Infections in Open Colectomies. [Journal Article]
    Dis Colon Rectum. 2016 Aug; 59(8):733-42.Poeran J, Wasserman I, … Mazumdar M
  • CONCLUSIONS: The study was limited by its lack of detailed clinical information in the billing data set used.In this national study assessing real-world use of prophylactic antibiotics in open colectomies, the type of antibiotic used appeared to be associated with up to 44% decreased odds for surgical site infections. Although there are numerous trials on optimal prophylactic strategies, studies that particularly focus on factors that influence the choice of prophylactic antibiotic might provide insights into ways of reducing the burden of surgical site infections in colorectal surgeries.
  • Molecular characterization of carbapenemase genes in Acinetobacter baumannii in China. [Journal Article]
    Genet Mol Res. 2016 Mar 31; 15(1)Fang F, Wang S, … Yu GQ
  • Acinetobacter baumannii is an aerobic non-motile Gram-negative coccobacillus, and it is one of the most important nosocomial pathogens worldwide. The aim of this study was to determine the molecular epidemiology of the outbreak strains. Between March 2011 and March 2014, a total of 205 strains of A. baumannii were isolated from patients at the Nanyang City Center Hospital. The blaOXA-23, blaOXA-2…
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