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6,749,020 results
  • In silico approach to calculate the transcript capacity. [Journal Article]
    Genomics Inform 2019; 17(3):e31Lee YS, Won KH, … Shin D
  • We sought the novel concept, transcript capacity (TC) and analyzed TC. Our approach to estimate TC was through an in silico method. TC refers to the capacity that a transcript exerts in a cell as enzyme or protein function after translation. We used the genome-wide association study (GWAS) beta effect and transcription level in RNA-sequencing to estimate TC. The trait was body fat percent and the…
  • Optimization of a microarray for fission yeast. [Journal Article]
    Genomics Inform 2019; 17(3):e28Kim DU, Lee M, … Hoe KL
  • Bar-code (tag) microarrays of yeast gene-deletion collections facilitate the systematic identification of genes required for growth in any condition of interest. Anti-sense strands of amplified bar-codes hybridize with ~10,000 (5,000 each for up- and down-tags) different kinds of sense-strand probes on an array. In this study, we optimized the hybridization processes of an array for fission yeast…
  • FusionScan: accurate prediction of fusion genes from RNA-Seq data. [Journal Article]
    Genomics Inform 2019; 17(3):e26Kim P, Jang YE, Lee S
  • Identification of fusion gene is of prominent importance in cancer research field because of their potential as carcinogenic drivers. RNA sequencing (RNA-Seq) data have been the most useful source for identification of fusion transcripts. Although a number of algorithms have been developed thus far, most programs produce too many false-positives, thus making experimental confirmation almost impos…
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