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(cerebrospinal fluid to blood glucose ratio)
280 results
  • Infective patterns of cryptococcosis in patients with connective tissue disease: a retrospective study. [Journal Article]
    Clin Rheumatol. 2020 Apr 03 [Online ahead of print]Lao M, Gong Y, … Chen D
  • CONCLUSIONS: Cryptococcosis develops in various organs. Typical radiological manifestation accompanied with positive serum CrAg provides helpful clues for the diagnosis. Lumbar puncture is a critical diagnostic method to distinguish CM. The accumulated dose of GC is associated with cryptococcosis in patients with CTD.Key Points• Pulmonary cryptococcosis is suspected if pulmonary nodules adjacent to the pleura are present, with serum CrAg positive.• Cryptococcal meningitis has insidious onset and the diagnosis mainly depends on lumber puncture.• Cryptococcal sepsis is not rare and needs timely blood culture in suspected patients.
  • A case report of cryptococcal meningitis associated with ruxolitinib. [Case Reports]
    Medicine (Baltimore). 2020 Mar; 99(13):e19587.Tsukui D, Fujita H, … Hirata K
  • We herein report a 76-year-old Japanese man with myelofibrosis who developed cryptococcal meningitis. After treatment for 5 months with ruxolitinib, the patient presented with fever and disturbance of consciousness. Marked nuchal stiffness was noted. The magnetic resonance imaging results of the brain were normal. Lumbar puncture showed an opening cerebrospinal fluid (CSF) pressure of 110 mm H2O,…
  • [Meningococcemia: Different Serotypes in the Same Region]. [Case Reports]
    Mikrobiyol Bul. 2020 Jan; 54(1):163-170.Aladağ Çiftdemir N, Duran R, … Ünal Şahin N
  • Meningococcal infections are important health problems causing high morbidity and mortality. Neisseria meningitidis have 13 serogroups. A, B, C, Y and W135 are the most common causes of invasive disease among those serogroups. The distribution of the serogroups differs according to the geographical regions and the age groups. In this case report, two cases of meningococcemia infected with serogro…
  • Glucose transporter type 1 deficiency syndrome and the ketogenic diet. [Review]
    J Inherit Metab Dis. 2019 Oct 12 [Online ahead of print]Schwantje M, Verhagen LM, … Fuchs SA
  • Glucose transporter type 1 deficiency syndrome (GLUT1DS) is characterised by deficient glucose transport over the blood-brain barrier and reduced glucose availability in the brain. This causes epilepsy, movement disorders, and cognitive impairment. Treatment with ketogenic diet provides ketones as alternative energy source. However, not all GLUT1DS patients are on dietary treatment (worldwide reg…
  • Blood and cerebrospinal fluid characteristics in neonates with a suspected central nervous system infection. [Journal Article]
    Medicine (Baltimore). 2019 Jun; 98(25) Blauw D, Bruning A, … Pajkrt D
  • Clinical signs and symptoms of central nervous system (CNS) infections in neonates are often nonspecific. Therefore, cerebrospinal fluid (CSF) analysis is performed to diagnose CNS infections. Data on combined microbiological results and their correlation with biochemical characteristics in CSF and blood in infants younger than 90 days are limited. This study provides an overview of microbiologic…
  • [A rare case of Streptococcus salivarius meningitis in elderly]. [Case Reports]
    Rinsho Shinkeigaku. 2019 Jun 22; 59(6):371-374.Kuzume D, Morimoto Y, … Yamasaki M
  • An 80-year-old man who had chronic heart failure and atrial fibrillation was refered to our hospital because of acute onset of fever and consciousness disturbance. Neurological examinations revealed deteriorated consciousness, nuchal rigidity and Kernig's sign. A lumber puncture yielded clouded fluid with a WBC 11,200/μl (polynuclear cell 94%), 758 mg/dl of protein, 1 mg/dl of glucose, 0.007 of c…
  • Importance of Treatment Status in Links Between Type 2 Diabetes and Alzheimer's Disease. [Journal Article]
    Diabetes Care. 2019 05; 42(5):972-979.McIntosh EC, Nation DA, Alzheimer’s Disease Neuroimaging Initiative
  • CONCLUSIONS: Treatment status may alter the relationship between type 2 diabetes and both AD biomarker profile and risk for dementia. UD is associated with elevated tau pathology and risk for dementia, whereas TD is not. Although this study is observational and therefore causality cannot be inferred, findings support the potential importance of treatment status in AD risk associated with type 2 diabetes.
  • Effects of running on adiponectin, insulin and cytokines in cerebrospinal fluid in healthy young individuals. [Journal Article]
    Sci Rep. 2019 Feb 13; 9(1):1959.Schön M, Kovaničová Z, … Ukropcová B
  • Exercise can prevent the sedentary lifestyle-related risk of metabolic and cognitive decline, but mechanisms and mediators of exercise effects on human brain are relatively unexplored. We measured acute exercise-induced changes in adiponectin, insulin and other bioactive molecules in cerebrospinal fluid (CSF) and serum from young lean individuals. Samples of serum and CSF were obtained before and…
  • Overall cognitive profiles in patients with GLUT1 Deficiency Syndrome. [Journal Article]
    Brain Behav. 2019 03; 9(3):e01224.De Giorgis V, Masnada S, … Veggiotti P
  • CONCLUSIONS: Our results were consistent with the hypothesis that timing of the diet introduction is a predictive factor of cognitive outcome in these patients, confirming that earlier initiation of the diet may prevent the onset of all GLUT1DS symptoms: epilepsy, movement disorders, and cognitive impairment.
  • Capnocytophaga canimorsus Meningitis: Diagnosis Using Polymerase Chain Reaction Testing and Systematic Review of the Literature. [Journal Article]
    Infect Dis Ther. 2019 Mar; 8(1):119-136.Hansen M, Crum-Cianflone NF
  • CONCLUSIONS: C. canimorsus meningitis is a rare but increasingly important clinical entity occurring in patients of all ages, typically after dog exposure. While classically considered an infection among immunocompromised patients, most cases have occurred in previously healthy, immunocompetent persons. Diagnosis may be rapidly established by PCR, and this test should be considered in culture-negative cases with associated exposures. Outcome was generally favorable after a median antibiotic duration of 15 days.
  • Cytokine profiles in cerebrospinal fluid of patients with meningitis at a tertiary general hospital in China. [Journal Article]
    J Microbiol Immunol Infect. 2018 Nov 09 [Online ahead of print]Liu Q, Gao Y, … Shao L
  • CONCLUSIONS: The excessive activation of immune response characterized by elevated levels of CSF Th1-, Th2- and Th17-type cytokines has been observed during CNS infection. Furthermore, we observed negative correlations between CSF IL-6 levels and CSF glucose and CSF/blood glucose ratio in CNS infection. And we suggested that combined CSF IL-6 levels with CSF glucose may serve as a novel biomarker pool for the differential of CNS infection.
  • Comparation of vancomycin penetration into cerebrospinal fluid in postoperative intracranial infection and community-acquired meningitis patients. [Journal Article]
    J Clin Pharm Ther. 2019 Apr; 44(2):216-219.Cai Y, Zhou L, … Zhang K
  • CONCLUSIONS: In postoperative intracranial infection patients and community-acquired meningitis patients, the vancomycin concentration in CSF was 1.90 ± 1.29 mg/L and 2.47 ± 1.15 mg/L, while the CSF-to-serum ratio was 0.19 ± 0.12 and 0.26 ± 0.12, respectively. There was a significant correlation between vancomycin serum concentration and bodyweight (P < 0.05). The CSF-to-serum ratio in postoperative intracranial infection patients was correlated to white blood cell count in CSF. However, in community-acquired meningitis patients, no relationship was seen with regards to CSF white blood cell count, protein or glucose.Cerebrospinal fluid vancomycin penetration was similar in postoperative intracranial infection and community-acquired meningitis patients. The CSF-to-serum ratio was only correlated to CSF white blood cell count in postoperative intracranial infection patients.
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