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(cerebrospinal puncture)
6,131 results
  • Increased Noradrenaline as an Additional Cerebrospinal Fluid Biomarker in PSP-Like Parkinsonism. [Journal Article]
    Front Aging Neurosci. 2020; 12:126.Cerroni R, Liguori C, … Massoud R
  • Academic centers utilize sequential clinical and neuroimaging assessments, including morphometric ratios, to obtain an unequivocal diagnosis of the non-synucleinopathic forms of Parkinsonism, such as progressive supranuclear palsy (PSP), however, a 1-2 year follow-up is required. The on-going long-lasting trials using anti-tau antibodies for PSP patients might therefore be biased by the incorrect…
  • Sexual dimorphism in the cerebrospinal fluid total protein content. [Journal Article]
    Clin Chem Lab Med. 2020 Jun 29 [Online ahead of print]Castellazzi M, Pizzicotti S, … Pugliatti M
  • Objectives Cerebrospinal fluid (CSF) is a clear, colorless body fluid filling the central nervous system. The determination of the CSF total protein (TP) content represents an important screening test of various pathologies. We aimed to address the effect of sex and age on CSF TP content and the use of the current upper reference limits (URLs). Methods CSF TP content was analysed in a selected po…
  • Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in cerebrospinal fluid. [Journal Article]
    Neurology. 2020 Jun 25 [Online ahead of print]Virhammar J, Kumlien E, … Rostami E
  • Here we report a case of Covid-19-related acute necrotizing encephalopathy (ANE) where SARS-CoV-2 RNA was found in cerebrospinal fluid (CSF) 19 days after symptom onset after testing negative twice. Even though monocytes and protein levels in CSF were only marginally increased, and our patient never experienced a hyperinflammatory state, her neurological function deteriorated into coma. Magnetic …
  • Central nervous system candidiasis beyond neonates: Lessons from a nationwide study. [Journal Article]
    Med Mycol. 2020 Jun 23 [Online ahead of print]Chaussade H, Cazals X, … French Mycosis study group
  • Though candidiasis is the most frequent invasive fungal infection, Candida spp. central nervous system (CNS) infections are rare but severe. To further describe clinico-patho-radiological presentations of this entity, we report a retrospective study from January 2005 to December 2018 including patients aged ≥ 28 days with proven or probable CNS candidiasis in France. Twenty-four patients were inc…
  • Atraumatic versus Conventional Needles for Lumbar Puncture. [Journal Article]
    Acad Emerg Med. 2020 Jun 22 [Online ahead of print]Gottlieb M, Long B
  • Over 350,000 lumbar punctures (LP) are performed in acute care settings each year in the United States.1 Post-dural puncture headache (PDPH) is one of the most common complications after an LP, occurring in approximately 11% of patients,2 with one study reporting an occurrence rate of up to 36%.3 While PDPH has been attributed to multiple factors, needle tip design has been frequently investigate…
  • Talaromyces (Penicillium) species infection in the central nervous system. [Case Reports]
    J R Coll Physicians Edinb. 2020 Jun; 50(2):138-140.Chuah CH, Ong YC, … Chow TS
  • Talaromycosis typically occurs as an opportunistic infection among immunocompromised individuals. Infection caused by species other than T. marneffei is uncommon. While most reported cases describe infection in the lungs, we report an extremely rare intracranial Talaromyces species infection. This 61-year-old with end-stage renal disease who was unwell for the previous two months, presented with …
  • Cerebrospinal Fluid Norepinephrine and Neurocognition in HIV and Methamphetamine Dependence. [Journal Article]
    J Acquir Immune Defic Syndr. 2020 Jun 10 [Online ahead of print]Saloner R, Cherner M, … Ellis RJ
  • CONCLUSIONS: HIV and METH independently, but not additively, relate to noradrenergic excess in the CNS, and perturbations to noradrenergic function may represent a pathophysiological mechanism of HIV-related neurocognitive dysfunction. Consistent with prior reports that noradrenergic excess compromises hippocampal and prefrontal function, higher NE related to worse neurocognition, even among successfully-treated PWH. Pharmacological and psychosocial interventions that stabilize NE function may improve neurocognition in PWH.
  • Leptomeningeal metastasis in a marginal zone lymphoma, presenting as a delirium: case report. [Journal Article]
    BMC Geriatr. 2020 Jun 17; 20(1):213.Dreessen L, Maréchal N, … Beyer I
  • CONCLUSIONS: To the best of our knowledge a delirium in an older patient due to leptomeningeal disease in MZL has never been described. To date, rare reports of CNS invasion by MZL describe focal intracranial lesions. After exclusion of common etiologies, physicians should remain vigilant when confronted with a patient with history of MBL presenting neurological symptoms. This case illustrates the importance of low threshold for lumbar punctures in this population, also for those patients with normal imaging studies.
  • Neurotropism of SARS-CoV-2: COVID-19 presenting with an acute manic episode. [Case Reports]
    BMJ Case Rep. 2020 Jun 14; 13(6)Mawhinney JA, Wilcock C, … Roshanzamir S
  • A 41-year-old man with no significant medical history presented with acute behavioural disruption on the background of a 1-day history of severe headache and a 10-day history of dry cough and fever. He was sexually disinhibited with pressured speech and grandiose ideas. His behaviour worsened, necessitating heavy sedation and transfer to intensive care for mechanical ventilation despite no respir…
  • Diagnostic test accuracy of jolt accentuation for headache in acute meningitis in the emergency setting. [Review]
    Cochrane Database Syst Rev. 2020 Jun 11; 6:CD012824.Iguchi M, Noguchi Y, … Tsujimoto H
  • CONCLUSIONS: Jolt accentuation for headache may exclude diagnoses of meningitis in emergency settings, but high-quality evidence to support use of this test is lacking. Even where jolt accentuation of headache is negative, there is still the possibility of acute meningitis. This review identified the possibility of heterogeneity. However, factors that contribute to heterogeneity are incompletely understood, and should be considered in future research.
  • Cerebrospinal Fluid Findings of 36 Adult Patients with Autism Spectrum Disorder. [Journal Article]
    Brain Sci. 2020 Jun 08; 10(6)Runge K, Tebartz van Elst L, … Endres D
  • Autism spectrum disorder (ASD) is a common neurodevelopmental disorder characterized by difficulties with social interaction, repetitive behavior, and additional features, such as special interests. Its precise etiology is unclear. Recently, immunological mechanisms, such as maternal autoantibodies/infections, have increasingly been the subject of discussion. Cerebrospinal fluid (CSF) investigati…
  • Rickettsia typhi central nervous system infection. [Case Reports]
    IDCases. 2020; 21:e00852.Talhelm CF, Helms JL, … Deliz RJ
  • A 39 year-old male was residing along the south coast of Texas, the USA, presented with fever, myalgias, headaches, and weight loss for ten days. Symptoms and manifestations progressed to include nuchal rigidity, photophobia, hyponatremia, thrombocytopenia, and transaminitis despite the intravenous administration of ceftriaxone and azithromycin. A lumbar puncture performed in the Emergency Depart…
  • StatPearls: Lumbar Puncture [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Jane Louis A. LA Wyckoff Heights Medical Center Wray Anton A. AA Wyckoff Heights Medical Center BOOK
  • Lumbar puncture (LP), also referred to as “spinal tap,” is a commonly performed procedure that involves obtaining and sampling cerebrospinal fluid from the spinal cord. It was developed by Heinrich Quincke in the late 19th Century.[1] It is the gold standard diagnostic procedure in the diagnosis of meningitis, subarachnoid hemorrhage, and certain neurological disorders. It is also used in the mea…
  • Utility of measuring CSF hypocretin-1 level in patients with suspected narcolepsy. [Journal Article]
    Sleep Med. 2020 Mar 21; 71:48-51.Gabryelska A, Szmyd B, … Riha RL
  • CONCLUSIONS: Despite a high sensitivity and specificity, the MSLT is not always a reliable diagnostic test for narcolepsy and where this uncertainty exits, CSF hypocretin-1 concentrations <110 pg/ml can be useful. However, due to a lower PPV and specificity at this cut-off, it may also not be entirely reliable as a stand-alone diagnostic test, particularly in the context of severe depression.
  • Cervical Epidural and Subarachnoid Catheter Placement in Standing Adult Horses. [Journal Article]
    Front Vet Sci. 2020; 7:232.Hurcombe SD, Morris TB, … Hopster K
  • Horses underwent either cervical epidural space (CES) catheterization or subarachnoid space (SAS) catheterization while restrained in stocks, under deep sedation (detomidine and morphine) and local anesthesia (mepivacaine 2%) block. Catheters were placed under ultrasound guidance with visualization of the dura, SAS, and spinal cord between the first (C1) and second (C2) cervical vertebrae. Follow…
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