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771 results
  • Lipophilic statins inhibit Zika virus production in Vero cells. [Journal Article]
    Sci Rep 2019; 9(1):11461Españo E, Nam JH, … Kim JK
  • Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family. ZIKV infection has been associated with neurological complications such as microcephaly in newborns and Guillain-Barré syndrome in adults; thus, therapeutic agents are urgently needed. Statins are clinically approved for lowering cholesterol levels to prevent cardiovascular disease but have shown potential as antiviral drugs…
  • Interaction of statins with phospholipid bilayers studied by solid-state NMR spectroscopy. [Journal Article]
    Biochim Biophys Acta Biomembr 2019; 1861(3):584-593Galiullina LF, Scheidt HA, … Klochkov V
  • Statins are drugs that specifically inhibit the enzyme HMG-CoA reductase and thereby reduce the concentration of low-density lipoprotein cholesterol, which represents a well-established risk factor for the development of atherosclerosis. The results of several clinical trials have shown that there are important intermolecular differences responsible for the broader pharmacologic actions of statin…
  • Association between SLCO1B1 T521C polymorphism and risk of statin-induced myopathy: a meta-analysis. [Review]
    Pharmacogenomics J 2018; 18(6):721-729Xiang Q, Chen SQ, … Cui YM
  • Numerous studies have illustrated the relationship between SLCO1B1 T521C polymorphism and statin-induced myopathy risk; however, this association is not consistent. Three electronic databases (PubMed, EMBASE, and the Cochrane Library) were searched from inception to October 2017 to identify potential studies. The summary odds ratios (ORs) with 95% confidence intervals (CIs) were calculated from d…
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