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(chemotherapy)
3,362,101 results
  • Severe acute exacerbation of HCV infection in cancer patients who undergo chemotherapy: some issues. [Letter]
    J Viral Hepat. 2020 Jul 05 [Online ahead of print]Dai CY, Huang JF, … Yu ML
  • We read with interest the manuscript published by Li et al. reporting the severe acute exacerbation of hepatitis C virus (HCV) infection in cancer patients undergoing chemotherapy without anti-viral prophylaxis in their retrospective study. The authors concluded that HCV infection increases the risk of acute severe liver injury in cancer patients undergoing chemotherapy. Several issues have to be…
  • HIPEC with Cisplatin in a Patient with a Prior Hypersensitivity Reaction to Systemic Oxaliplatin. [Case Reports]
    Basic Clin Pharmacol Toxicol. 2020 Jul 05 [Online ahead of print]Morgan R, Parsad S, … Eng OS
  • Platinum-based chemotherapeutic agents are commonly used in the treatment of several cancers. While effective, they are often discontinued due to toxicities and hypersensitivity reactions (HSRs) that occur more frequently with repeated exposure. Following discontinuation of one agent, therapy may be continued with a second platinum salt, though the cross-reactivity between agents in this class is…
  • Similarity and difference in the characteristics of eosinophilic esophagitis between Western countries and Japan. [Review]
    Dig Endosc. 2020 Jul 05 [Online ahead of print]Ishimura N, Okimoto E, … Ishihara S
  • Over the past two decades, the incidence and prevalence of eosinophilic esophagitis (EoE) has risen rapidly, especially in Western countries, with cases in Japan also showing a gradual increase in recent years. However, similarities and differences regarding the characteristics of EoE between Western countries and Japan remain to be clearly elucidated. The current clinical guidelines for diagnosi…
  • Role of (Neo)adjuvant Denosumab for Giant Cell Tumor of Bone. [Review]
    Curr Treat Options Oncol. 2020 Jul 04; 21(8):68.Palmerini E, Staals EL, … Randall RL
  • Denosumab is a RANK ligand inhibitor approved for the treatment of giant cell tumor of bone. While the role of denosumab in the setting of advanced and unresectable disease is well established, its role in surgically resectable disease is currently under discussion. Several prospective and retrospective series on neoadjuvant therapy in potentially resectable tumor with high morbidity surgery repo…
  • Skp2 Depletion Reduces Tumor-Initiating Properties and Promotes Apoptosis in Synovial Sarcoma. [Journal Article]
    Transl Oncol. 2020 Jul 02; 13(10):100809.Wang J, Sato K, … Hoang BH
  • Synovial sarcoma (SS) is an aggressive soft-tissue cancer with a poor prognosis and a propensity for local recurrence and distant metastasis. In this study, we investigated whether S phase kinase-associated protein (Skp2) plays an oncogenic role in tumor initiation, progression, and metastasis of SS. Our study revealed that Skp2 is frequently overexpressed in SS specimens and SS18-SSX transgenic …
  • Characterization of serial hyperpolarized 13C metabolic imaging in patients with glioma. [Journal Article]
    Neuroimage Clin. 2020 Jun 24; 27:102323.Autry AW, Gordon JW, … Li Y
  • CONCLUSIONS: Serial measures of HP [1-13C]pyruvate metabolism displayed consistency in the NAWM of healthy volunteers and patients. Both kPL and kPB were globally elevated following bevacizumab treatment, while progressive disease demonstrated elevated kPL in gadolinium-enhancing and non-enhancing lesions. Larger prospective studies with homogeneous patient populations are planned to evaluate metabolic changes following treatment.
  • Treatment with Hydroxychloroquine, Azithromycin, and Combination in Patients Hospitalized with COVID-19. [Journal Article]
    Int J Infect Dis. 2020 Jul 02 [Online ahead of print]Arshad S, Kilgore P, … Henry Ford COVID-19 Task Force
  • CONCLUSIONS: The United States is in an acceleration phase of the COVID-19 pandemic. Currently there is no known effective therapy or vaccine for treatment of SARS-CoV-2, highlighting urgency around identifying effective therapies.In this multi-hospital assessment, when controlling for COVID-19 risk factors, treatment with hydroxychloroquine alone and in combination with azithromycin was associated with reduction in COVID-19 associated mortality. Prospective trials are needed to examine this impact.
  • Overcoming resistance to anti-PD-1 immunotherapy in lymphoepithelioma-like carcinoma: A case report and review of the literature. [Case Reports]
    Lung Cancer. 2020 Jun 24; 146:335-340.Tang Z, Fang R, … Tang Y
  • CONCLUSIONS: The LELC patient progressed after first-line chemotherapy, was treated by immunotherapy alone and progressed again. To overcome the developed resistance to immunotherapy, chemotherapy with nedaplatin plus paclitaxel in addition to nivolumab was administered and a progression-free survival (PFS) of 5 months was achieved. It was also observed that the blood levels of neuron-specific enolase may act as an efficacy biomarker in LELC. Patients with this rare disorder resistant to anti-PD-1 immunotherapy might benefit from therapy based on PD-1 inhibition; this is a future avenue of research.
  • Clinical and Multimodal Imaging Findings in Disseminated Mycobacterium Chimaera. [Journal Article]
    Ophthalmol Retina. 2020 Jul 02 [Online ahead of print]Deaner JD, Lowder CY, … Srivastava SK
  • CONCLUSIONS: Ophthalmologists should be aware of the systemic and ocular findings of this rare life-threatening disease. Multimodal imaging is useful in corroborating a diagnosis of ocular M. Chimaera and particularly in evaluating patient response to therapy as choroidal activity appears to mimic systemic activity. Treating physicians should be aware of the co-occurrence of choroiditis and osteomyelitis. Choroidal neovascular membrane can also be a late complication of this disease.
  • Functionalized exosome harboring bioactive molecules for cancer therapy. [Journal Article]
    Cancer Lett. 2020 Jul 02 [Online ahead of print]Kim YK, Choi Y, … Kim IS
  • Exosomes are nanosized vesicles with a lipid membrane that are secreted by most cells and play a crucial role as intermediates of intercellular communication because they carry bioactive molecules. Exosomes are promising for drug delivery of chemicals, proteins, and nucleic acids owing to their inherent properties such as excellent biocompatibility, high tumor targetability, and prolonged circula…
  • Targeting non-apoptotic cell death in cancer treatment by nanomaterials: Recent advances and future outlook. [Review]
    Nanomedicine. 2020 Jul 02 [Online ahead of print]Sepand MR, Ranjbar S, … Raoufi M
  • Many tumors develop resistance to most of the apoptosis-based cancer therapies. In this sense targeting non-apoptotic forms of cell death including necroptosis, autophagy and ferroptosis may have therapeutic benefits in apoptosis-defective cancer cells. Nanomaterials have shown great advantages in cancer treatment owing to their unique characteristics. Besides, the capability of nanomaterials to …
  • Graphene nanoribbons: A promising nanomaterial for biomedical applications. [Review]
    J Control Release. 2020 Jul 02 [Online ahead of print]Johnson AP, Gangadharappa HV, Pramod K
  • Graphene nanoribbons (GNRs) are narrow lengthened strips of single-layer graphene. Among the graphene family of nanomaterials, GNRs are remarkable materials due to their attractive physical, chemical, electrical, mechanical, thermal, and optical properties. They have an ultra-high surface area. Graphene-oxide nanoribbons (GONRs), the oxygenated derivative of GNRs, offer more possibilities in the …
  • Nanovehicles for co-delivery of anticancer agents. [Review]
    Drug Discov Today. 2020 Jul 02 [Online ahead of print]Zeinali M, Abbaspour-Ravasjani S, … Hamblin MR
  • Effective cancer treatment remains a significant challenge in human healthcare. Although many different types of cancer therapy have been tested, scientists have now concluded that combinations of drugs, or drugs plus gene therapy, can target multiple pathways to fight cancer. Nanovehicles can increase drug uptake inside tumor cells, improve biodistribution and accumulation at tumor sites. The ab…
  • Bisphosphonates in common pediatric and adult bone sarcomas. [Journal Article]
    Bone. 2020 Jul 02 [Online ahead of print]Heymann MF, Lezot F, Heymann D
  • The therapeutic strategies proposed currently for bone sarcomas are based on neo-adjuvant chemotherapy, delayed en-bloc wide resection, and adjuvant chemotherapy. Unfortunately, bone sarcomas are characterized by high rates of poor drug response, with a high risk of drug resistance, local recurrence and/or a high propensity for induced metastases. The pathogenesis of bone sarcomas is strongly ass…
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