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9,067 results
  • Diffuse melanosis cutis: a rare manifestation of metastatic melanoma. [Journal Article]
    BMJ Case Rep 2019; 12(8)Chinai B, Piazza M, … Roy S
  • Diffuse melanosis cutis (DMC) is an extremely rare and late complication of metastatic melanoma (MM). It involves the progressive blue-grey discolouration of the skin and mucous membranes, occurring approximately 1 year after diagnosis of MM. The pathogenesis of DMC is unknown, although specific growth factors, such as alpha-melanocyte stimulating hormone, hepatocyte growth factor and endothelin-…
  • Conjunctival Melanocytic Nevi With Granular Cell Change. [Journal Article]
    Arch Pathol Lab Med 2019Eiger-Moscovich M, Eagle RC, … Milman T
  • CONCLUSIONS: Granular cell change in melanocytic nevi is an underrecognized finding that can simulate melanoma clinically and histopathologically. Young age at diagnosis, lack of associated conjunctival melanosis, bulbar location, cysts, and the absence of mitotic figures with a low Ki-67 proliferative index are helpful clinical and pathologic diagnostic clues.
  • The role and mechanism of Asian medicinal plants in treating skin pigmentary disorders. [Review]
    J Ethnopharmacol 2019; 245:112173Li Y, Huang J, … Zeng Q
  • CONCLUSIONS: Asian medicinal plants, especially their active ingredients, have multilevel effects on melanogenesis by regulating melanogenesis-related genes or signaling pathways. They are of great clinical value for the treatment of skin pigmentary disorders. However, the experimental effect, safety, and functional mechanism of the medicinal plants require further determination before studying their clinical efficacy.
  • GNAQ and PMS1 Mutations Associated with Uveal Melanoma, Ocular Surface Melanosis, and Nevus of Ota. [Case Reports]
    Ocul Oncol Pathol 2019; 5(4):267-272Toomey CB, Fraser K, … Lin JH
  • G protein mutations are common in uveal melanomas, and the vast majority target amino acid residue Q209 in either GNAQ or GNA11. The GNAQ R183Q mutation is found in a small fraction of uveal melanomas. We report a patient with an unusual presentation of uveal melanoma arising at an early age in the setting of congenital skin and ocular surface melanosis. A 34-year-old Hispanic female with congeni…
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