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Unbound Medicine.
(chloasma)
9,261 results
  • Impact of Riehl's melanosis on quality of life in Korean patients: A cross-sectional comparative study. [Journal Article]
    J Dermatol. 2020 Jun 26 [Online ahead of print]Woo YR, Jung Y, … Park HJ
  • The prevalence of Riehl's melanosis in Korea is increasing. However, little is known about the psychosocial burden of patients with Riehl's melanosis. This study was aimed to examine the level of psychosocial impact of Riehl's melanosis. A cross-sectional study recruited 52 patients with Riehl's melanosis who were asked to complete questionnaires requesting demographic characteristics, the Dermat…
  • Identification of rhein as the metabolite responsible for toxicity of rhubarb anthraquinones. [Journal Article]
    Food Chem. 2020 Jun 18; 331:127363.Cheng Y, Zhang H, … Qiao B
  • Rhubarb is a popular food in Europe with laxative properties attributed to anthraquinones. Long term usage of rhubarb anthraquinones has been linked to colonic toxicity, including the formation of melanosis coli, which is associated with increased risk of colon cancer. The major purgative anthraquinone in rhubarb is thought to be sennoside A, which is metabolised by colonic microflora. Here, we s…
  • Melanosis of the bladder: A rare diagnosis. [Case Reports]
    Urol Case Rep. 2020 Nov; 33:101283.Lopategui DM, Griffith RC, Santos Cortes J
  • Melanosis of the bladder is characterized by dark, velvety bladder mucosa due to melanin deposition. Less than 25 cases have been reported. We present a 45-year-old male undergoing work up for obstructive and storage irritative lower urinary tract symptoms, found to have diffuse bladder melanosis on cystoscopy with bladder biopsy, and detrusor overactivity on urodynamic study. Although bladder me…
  • Guanine Deaminase in Human Epidermal Keratinocytes Contributes to Skin Pigmentation. [Journal Article]
    Molecules. 2020 Jun 05; 25(11)Jung JM, Noh TK, … Chang SE
  • Epidermal keratinocytes are considered as the most important neighboring cells that modify melanogenesis. Our previous study used microarray to show that guanine deaminase (GDA) gene expression is highly increased in melasma lesions. Hence, we investigated the role of GDA in skin pigmentation. We examined GDA expression in post-inflammatory hyperpigmentation (PIH) lesions, diagnosed as Riehl's me…
  • StatPearls: Riehl Melanosis [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Daadaa Najla N Military Hospital of Tunis Ben Tanfous Azima A Habib Thameur Hospital BOOK
  • Facial melanoses affecting the face and neck region are of considerable concern to darker-skinned people. Although many facial melanoses, such as melasma, are well defined clinically, rendering them easy to diagnose, others have overlapping clinical morphology as well as histopathology.[1][2] Riehl melanosis (RM), commonly considered as a pigmented contact dermatitis (PCD), is one such condition …
  • A case of acanthosis nigricans in a HIV-infected patient. [Case Reports]
    BMC Infect Dis. 2020 May 20; 20(1):360.Iacovelli A, Mezzaroma I, … Palange P
  • CONCLUSIONS: This is the second report of AN found in patients with AIDS and apparently responsive to prolonged antiretroviral treatment. Possible explanations of this association are still not completely understood, probably related to virus-induced changes in lipid metabolism. Our experience suggests that HIV testing should always be considered in the setting of apparently idiopathic AN.
  • Differential diagnosis and management of melanocytic lesions of the ocular surface [Journal Article]
    Orv Hetil. 2020 04 01; 161(15):563-574.Tóth G, Szalai E, … Szentmáry N
  • Our purpose is to summarize the actual knowledge about melanocytic lesions of the ocular surface (conjunctival nevus, primary acquired melanosis and conjunctival melanoma),especially their clinical appearance, differential diagnosis and treatment.Conjunctival nevus is the most common benign, conjunctival melanocytic lesion.Primary acquired melanosis mainly presents in middle-aged or elderly indiv…
  • Epilepsy in isolated parenchymal neurocutaneous melanosis: A systematic review. [Review]
    Epilepsy Behav. 2020 Jun; 107:107061.Pellino G, Gencarelli J, … Faggioli R
  • CONCLUSIONS: Antiepileptic drugs were effective in the majority of patients with epilepsy with parenchymal melanosis. In case of multifocal distribution, more than one-third of patients presented a drug-resistant epilepsy. Epilepsy surgery is the best choice in patients with isolated amygdala localization. We propose the recognition of a multifactorial nature of cognitive impairment in neuromelanosis, emphasizing the role of drug-resistant epilepsy.
  • [A woman with a skin lesion suspected for melanoma]. [Journal Article]
    Ned Tijdschr Geneeskd. 2020 Feb 27; 164Post NF, Huis In 't Veld E, Crijns MB
  • We saw a 59-year-old patient who was treated with dabrafenib and trametinib because of metastatic melanoma. She had an asymptomatic, black-blue macula in the excision scar. Histopathology showed tumoral melanosis. This is an histological term for dermal aggregates of melanophages, associated with regression of melanoma.
  • Melanonychia associated with subungual follicular inclusions: report of three cases. [Case Reports]
    An Bras Dermatol. 2020 Mar - Apr; 95(2):217-220.Câmara de Oliveira M, Barcaui CB, … Piñeiro-Maceira J
  • Melanonychia is the change in the coloration of the nail plate resulting from the deposition of melanin. Among its causes are melanocytic hyperplasia, melanocytic activation and nail melanoma. Subungual follicular inclusions are histological findings of unknown etiology, possibly related to trauma. We present three cases of melanonychia of different etiologies with subungual follicular inclusions…
  • Melanogenic Properties and Expression Profiles of Melanogenic Paracrine Molecules in Riehl's Melanosis. [Journal Article]
    Int J Mol Sci. 2020 Mar 02; 21(5)Woo YR, Park HE, … Park HJ
  • Riehl's melanosis is a hyperpigmentary disorder that occurs predominantly on the face and neck. To date, the pathogenesis of Riehl's melanosis with regards to the melanogenic properties and paracrine melanogenic molecules has not well been studied. This study was aimed to provide a novel perspective on the pathogenesis of Riehl's melanosis by identifying the relevant paracrine melanogenic molecul…
  • Melanosis coli: A comprehensive review. [Review]
    Gastroenterol Hepatol. 2020 May; 43(5):266-272.Yang N, Ruan M, Jin S
  • Melanosis coli (MC) is a common condition characterized by a black or brown pigment deposited in the colorectal mucosa. It is a reversible condition that is influenced by many factors, such as living habits and bowel function. However, the epidemiology and etiology of MC are still unclear. Most studies show that there is a significant correlation between the use of anthraquinone laxatives and the…
  • Benign tumoral melanosis of a cervical lymph node in a child. [Case Reports]
    Int J Pediatr Otorhinolaryngol. 2020 Jan 30; 132:109916.Boscoe EF, Hararah MK, … Kelley P
  • We present a pediatric case of benign tumoral melanosis in a cervical lymph node arising from congenital pigmented lesions of the anterior neck. This is the first reported pediatric case not associated with regressed melanoma or trauma. Tumoral melanosis is a rare phenomenon which describes a pigmented lesion like melanoma; however, histology demonstrates melanin-laden macrophages without maligna…
  • Global Prevalence of Tobacco Use in Adolescents and Its Adverse Oral Health Consequences. [Journal Article]
    Open Access Maced J Med Sci. 2019 Nov 15; 7(21):3659-3666.Nazir MA, Al-Ansari A, … Almas K
  • CONCLUSIONS: There was a high prevalence of tobacco use among male and female adolescents around the globe. Available evidence suggests a strong association between smoking and compromised oral health among adolescents. Globally, measures should be taken to prevent and control the menace of tobacco use to reduce systemic and oral complications.
  • Histopathological Features of Riehl Melanosis. [Journal Article]
    Am J Dermatopathol. 2020 Feb; 42(2):117-121.Kim SM, Lee ES, … Kim YC
  • Histological features of Riehl melanosis have rarely been compared between lesional and perilesional normal skin and have not been precisely described using quantitative or immunohistochemical analysis or electron microscopic findings. To investigate the histopathological and immunohistochemical features of lesional and perilesional normal skin of patients with Riehl melanosis, we retrospectively…
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