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2,076 results
  • LiverTox: Clinical and Research Information on Drug-Induced Liver Injury: Sulfonylureas [BOOK]
    National Institute of Diabetes and Digestive and Kidney Diseases: Bethesda (MD)BOOK
  • The sulfonylureas are a class of agents that lower blood sugar as a result of increasing release of insulin from the pancreas. The sulfonylureas are used for the therapy of mild-to-moderate type 2 diabetes in conjunction with diet, and can be used alone or in combination with metformin, thiazolidinediones or other hypoglycemic agents. The sulfonylureas have been associated with rare cases of idio…
  • Sulfonylurea derivatives and cancer, friend or foe? [Review]
    Eur J Pharmacol 2019; 861:172598Hendriks AM, Schrijnders D, … Landman GWD
  • Type 2 diabetes mellitus (T2DM) is associated with a higher risk of cancer and cancer-related mortality. Increased blood glucose and insulin levels in T2DM patients may be, at least in part, responsible for this effect. Indeed, lowering glucose and/or insulin levels pharmacologically appears to reduce cancer risk and progression, as has been demonstrated for the biguanide metformin in observation…
  • StatPearls: Sulfonylureas [BOOK]
    StatPearls Publishing: Treasure Island (FL) Costello Ryan A. RA Shivkumar Abhijit A St. Bernards Hospital, Jonesboro-AR BOOK
  • This class of medications represents a group of anti-hyperglycemic agents mainly used in the treatment of type 2 diabetes mellitus. Sulfonylureas, commonly divided into first and second generations, can be utilized as adjuvant therapy with metformin in patients not at target hemoglobin A1c after three months on biguanides. If a patient’s hemoglobin A1c initially is greater than 9.0%, providers ca…
  • Drugs and Lactation Database (LactMed): Chlorpropamide [BOOK]
    National Library of Medicine (US): Bethesda (MD)BOOK
  • Limited data indicate that amounts of chlorpropamide in breastmilk are unlikely to affect a breastfed infant. Short-acting drugs are generally preferred while breastfeeding a neonate to avoid drug accumulation. Monitor breastfed infants for signs of hypoglycemia such as jitteriness, excessive sleepiness, poor feeding, seizures cyanosis, apnea, or hypothermia. If there is concern, monitoring of th…
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