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Unbound Medicine.
(cholecystokinin secretin test)
409 results
  • The Impact of Food Bioactives on Health: in vitro and ex vivo models: STC-1 Cells [BOOK]
    . Springer: Cham (CH)Verhoeckx K, Cotter P, … Wichers HMcCarthy T, Green BD, … Giblin LBOOK
  • Gastrointestinal hormones such as cholecystokinin (CCK), glucagon like peptide 1 (GLP-1), and peptide YY (PYY) play an important role in suppressing hunger and controlling food intake. These satiety hormones are secreted from enteroendocrine cells present throughout the intestinal tract. The intestinal secretin tumor cell line (STC-1) possesses many features of native intestinal enteroendocrine c…
  • [Importance of functional diagnostics in gastroenterology]. [Review]
    Internist (Berl). 2018 01; 59(1):25-37.Hollenbach M, Hoffmeister A, … Mössner J
  • In this review article important and frequently used investigation methods for gastrointestinal functional diagnostics are presented. Some other rarely used special investigations are also explained. The hydrogen breath test is simple to carry out, ubiquitously available and enables the detection of lactose, fructose and sorbitol malabsorption. Furthermore, by the application of glucose, the test…
  • Secretin: historical perspective and current status. [Historical Article]
    Pancreas. 2014 Mar; 43(2):162-82.Chey WY, Chang TM
  • This review describes the history of secretin discovery, identification, purification, and structural determination; cloning of secretin and its receptor; synthetic secretin; and highly specific and sensitive radioimmunoassay to define the characteristic physiological role on postprandial pancreatic fluid and bicarbonate secretion, which requires robust potentiation by cholecystokinin. Secretin p…
  • Update on endoscopic pancreatic function testing. [Editorial]
    World J Gastroenterol. 2011 Sep 21; 17(35):3957-61.Stevens T, Parsi MA
  • Hormone-stimulated pancreatic function tests (PFTs) are considered the gold standard for measuring pancreatic exocrine function. PFTs involve the administration of intravenous secretin or cholecystokinin, followed by collection and analysis of pancreatic secretions. Because exocrine function may decline in the earliest phase of pancreatic fibrosis, PFTs are considered accurate for diagnosing chro…
  • Secretin is not necessary for exocrine pancreatic development and growth in mice. [Journal Article]
    Am J Physiol Gastrointest Liver Physiol. 2011 Nov; 301(5):G791-8.Sans MD, Sabbatini ME, … Williams JA
  • Adaptive exocrine pancreatic growth is mediated primarily by dietary protein and the gastrointestinal hormone cholecystokinin (CCK). Feeding trypsin inhibitors such as camostat (FOY-305) is known to induce CCK release and stimulate pancreatic growth. However, camostat has also been reported to stimulate secretin release and, because secretin often potentiates the action of CCK, it could participa…
  • Pancreatic function testing: here to stay for the 21st century. [Historical Article]
    World J Gastroenterol. 2008 May 28; 14(20):3149-58.Lieb JG, Draganov PV
  • The diagnosis of Chronic Pancreatitis (CP) is based on the detection of abnormal structure or function of the diseased pancreas. The pancreatic function tests more accurately determine the presence of CP than tests of structure, especially for early stage disease. The function tests can be divided into two categories: non-invasive and invasive. The invasive "tube" tests can reliably detect mild, …
  • Endoscopy-based pancreatic function tests. [Review]
    Curr Gastroenterol Rep. 2006 Apr; 8(2):127-31.Pungpapong S, Raimondo M
  • Direct pancreatic function tests have been the mainstay for the diagnosis of pancreatic exocrine insufficiency. Due to their cumbersome nature and limited availability there is a continuous search for a rapid and inexpensive test of pancreatic function. Endoscopic approaches to evaluate pancreatic function have been assessed. This article critically reviews the current evidence related to this no…
  • Exocrine pancreatic dysfunction in sepsis. [Journal Article]
    Eur J Clin Invest. 2003 Mar; 33(3):239-43.Tribl B, Sibbald WJ, … Madl C
  • CONCLUSIONS: Sepsis is associated with secretory pancreatic dysfunction that is worse in septic shock than in sepsis without shock. Impaired exocrine function was significantly correlated to the APACHE III and SOFA scores.
  • Medical therapy for chronic pancreatitis pain. [Journal Article]
    Curr Gastroenterol Rep. 2003 Apr; 5(2):110-6.Singh VV, Toskes PP
  • Chronic pancreatitis should be considered in all patients with unexplained abdominal pain. Management of abdominal pain in these patients continues to pose a formidable challenge. The importance of small duct disease without radiographic abnormalities is now a well-established concept. It is meaningful to determine whether patients with chronic pancreatitis have small duct or large duct disease b…
  • Analysis of duodenal drainage fluid after cholecystokinin (CCK) stimulation in healthy volunteers. [Journal Article]
    Pancreas. 2002 Nov; 25(4):350-4.Conwell DL, Zuccaro G, … Dumot JA
  • CONCLUSIONS: Pancreatic lipase concentrations in duodenal fluid increase nearly threefold after cholecystokinin stimulation in healthy volunteers. This magnitude of enzyme secretory response may be a marker of pancreatic function and could potentially lead to a more clinically useful and simpler pancreatic function test. This physiologic study serves as the basis for our further investigations of cholecystokinin-stimulated lipase concentrations as a new test in the assessment of pancreatic insufficiency.
  • Cholecystokinin-stimulated peak lipase concentration in duodenal drainage fluid: a new pancreatic function test. [Journal Article]
    Am J Gastroenterol. 2002 Jun; 97(6):1392-7.Conwell DL, Zuccaro G, … Shay SS
  • CONCLUSIONS: Lipase concentration in duodenal fluid increases nearly 3-fold from baseline after CCK stimulation in healthy volunteers but is markedly reduced in patients with chronic pancreatic disease. Peak lipase concentration is a significant predictor of chronic pancreatitis and correlates with severity of pancreatic disease. Aspiration of duodenal drainage fluid with a Dreiling tube and analysis with a laboratory autoanalyzer are less cumbersome than marker perfusion and back titration techniques. Measurement of enzyme concentration instead of output could lead to the development of an endoscopic or through-the-scope screening method for assessing patients with suspected chronic pancreatitis or chronic abdominal pain.
  • [Fecal elastase-1 determination in the diagnosis of chronic pancreatitis]. [Journal Article]
    Gastroenterol Hepatol. 2002 Jun-Jul; 25(6):377-82.Martínez J, Laveda R, … Pérez-Mateo M
  • CONCLUSIONS: Fecal elastase-1 determination is an effective indirect method in the diagnosis of patients with advanced chronic pancreatitis. However, when the disease is in the early stages, its sensitivity is no greater than that of other indirect tests. The greatest advantage of this test is its high specificity.
  • The pancreas. [Historical Article]
    Mt Sinai J Med. 2000 Jan; 67(1):68-75.Baron JH
  • Pancreatic secretion was first studied at The Mount Sinai Hospital by Crohn in 1912, but measurements of pancreatic enzymes in duodenal aspirate or feces were found unhelpful in diagnosis. Such pancreatic tests fell into disuse because of advances in radiology of the biliary tree in the 1920s. Once extracts of secretin and cholecystokinin-pancreozymin became available from Sweden in the 1930s, it…
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