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3,464 results
  • Treatment of Pruritus Secondary to Liver Disease. [Review]
    Curr Gastroenterol Rep 2019; 21(9):48Düll MM, Kremer AE
  • Pruritus is a common extrahepatic symptom in various liver disorders, in particularly those with cholestatic features. This review summarizes epidemiology, pathophysiology, evidence-based therapeutic recommendations and currently investigated drugs for pruritus in hepatobiliary disorders.
  • Propylthiouracil-induced agranulocytosis as a rare complication of antithyroid drugs in a patient with Graves' disease. [Case Reports]
    Rev Assoc Med Bras (1992) 2019; 65(6):755-760Rabelo PN, Rabelo PN, … Reis MAL
  • CONCLUSIONS: We describe here the case of a young male patient with GD. For the treatment of hyperthyroidism, thioamides are effective options. Agranulocytosis induced by ATDs is a rare complication defined as the occurrence of a granulocyte count <500/mm3 after the use of ATDs. PTU was suspended, and filgrastim and antibiotics were prescribed. Radioiodine (RAI) or surgery are therapeutic alternatives. Due to problems with ATD use, a total thyroidectomy was proposed. The preoperative preparation was performed with beta-blocker, glucocorticoid, lithium carbonate, and Lugol solution. Cholestyramine is also an option for controlling hyperthyroidism. TT was performed without postoperative complications.Thionamide-induced agranulocytosis is a rare complication. With a contraindication to ATDs, RAI and surgery are definitive therapeutic options in GD. Beta-blockers, glucocorticoids, lithium carbonate, iodine, and cholestyramine may be an adjunctive therapy for hyperthyroidism.
  • [Sitosterolemia (phytosterolemia)]. [Review]
    Internist (Berl) 2019; 60(8):871-877Lütjohann D
  • Sitosterolemia or phytosterolemia is a rare autosomal recessive hereditary lipid storage disorder. It is caused by homozygous or compound heterozygous mutations in one of the two ABCG5 and ABCG8 genes encoding the intestinal and hepatic heterodimer ABCG5 (sterolin 1)/ABCG8 (sterolin 2) efflux transporters. These mutations lead to intestinal hyperabsorption and reduced hepatic secretion of cholest…
  • [Pruritus in systemic diseases : Common and rare etiologies]. [Review]
    Internist (Berl) 2019; 60(8):814-820Kremer AE, Mettang T
  • Chronic pruritus is a symptom of various internal disorders. In contrast to dermatological diseases, pruritus does not present with primary skin alterations in these patients. However, intense scratching my cause secondary skin changes such as abrasion, excoriation, prurigo nodularis, or in rare cases even scarring. The most common internal causes for chronic pruritus are chronic kidney disease, …
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