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7,766 results
  • L-type voltage-gated Ca2+ channel CaV1.2 regulates chondrogenesis during limb development. [Journal Article]
    Proc Natl Acad Sci U S A 2019Atsuta Y, Tomizawa RR, … Tabin CJ
  • All cells, including nonexcitable cells, maintain a discrete transmembrane potential (V mem), and have the capacity to modulate V mem and respond to their own and neighbors' changes in V mem Spatiotemporal variations have been described in developing embryonic tissues and in some cases have been implicated in influencing developmental processes. Yet, how such changes in V mem are converted into i…
  • Adjuvant therapies for the enhancement of microfracture technique in cartilage repair. [Journal Article]
    Orthop Rev (Pavia) 2019; 11(3):7950Schizas N, Savvidou O, … Papagelopoulos P
  • The classic technique of microfracture does not promote hyaline cartilage restoration. Subchondral bone perforations lead to the formation of a clot containing pluripotent progenitor cells and finally the cartilage defect is filled by fibrocartilage tissue. Researchers have focused on enhancing the quality of the newly formed tissue in cartilage defects after microfracture arthroscopic surgery. A…
  • BMP-3 promotes matrix production in cocultured stem cells and disc cells from low back pain patients. [Journal Article]
    Tissue Eng Part A 2019Hingert D, Barreto Henriksson H, … Brisby H
  • Low back pain is one of the most common disorders and believed to be due to intervertebral discs (IVDs) degeneration. Transplantation of human mesenchymal stem cells (hMSCs) is suggested as potential treatment option. BMP-3 growth factor promotes chondrogenesis and is proven effective in enhancing chondrogenesis in hMSCs pretreated with IL-1beta in hydrogel model. 3D co-cultures of hMSCs and disc…
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