- Can cell-free DNA testing be used in pregnancies with increased nuchal translucency? [Journal Article]
- UOUltrasound Obstet Gynecol 2019 Jul 13
- CONCLUSIONS: cfDNA does not appear to be the appropriate genetic test in fetuses with a NT above the 99th centile, given that 12-19% of the genetic anomalies were undetectable with the current tests. Additionally, 6.6% of fetuses will have a major structural abnormality identifiable using first-trimester ultrasound. This article is protected by copyright. All rights reserved.
- Laparoscopic surgery with spleen preservation to treat primary splenic pregnancy: Case report and literature review. [Case Reports]
- JOJ Obstet Gynaecol Res 2019 Jul 07
- Splenic pregnancy is a rare form of ectopic pregnancy, with only 21 cases reported in PubMed since 1970. Here we report the case of a healthy 28-year-old woman with splenic pregnancy who complained o…
Splenic pregnancy is a rare form of ectopic pregnancy, with only 21 cases reported in PubMed since 1970. Here we report the case of a healthy 28-year-old woman with splenic pregnancy who complained of menolipsis lasting 56 days and left upper quadrant pain lasting 30 days. The level of β-human chorionic gonadotropin in serum was 8399 mIU/mL, and transvaginal ultrasonography showed the uterine cavity to be empty without signs of adnexal mass. Subsequent abdominal ultrasonography detected a hyperechoic mass below the spleen containing an anechoic mass measuring 2.6 × 1.2 × 1.6 cm. Laparoscopy detected a gestational mass measuring 6.0 × 4.0 × 3.0 cm on the lower border of the spleen. Pregnancy tissues and a clot were removed under laparoscopic guidance, and the spleen was preserved. Our case suggests that removal of chorionic villi tissue, although not a standard procedure, may be effective for treating splenic pregnancy.
- Zika Virus Non-Structural Protein 1 Disrupts Glycosaminoglycans and Causes Permeability in Developing Human Placentas. [Journal Article]
- JIJ Infect Dis 2019 Jun 27
- CONCLUSIONS: These findings suggest that ZIKV NS1 contributes to placental dysfunction via modulation of glycosaminoglycans on trophoblasts and chorionic villi, resulting in increased permeability of human placentas.
- Rare autosomal trisomies (RATs): a comparison of the detection through cell-free DNA and chorionic villus sampling. [Journal Article]
- UOUltrasound Obstet Gynecol 2019 Jun 25
- CONCLUSIONS: Although there are strong parallels between RATs ascertained through these two methods, caution is needed in applying conclusions from CVS analysis to cfDNA testing, and vice versa. RATs identified through genome-wide cf-DNA tests have uncertain risks for fetal loss, growth restriction, or fetal abnormality. This article is protected by copyright. All rights reserved.
- Metabolomic Investigation of β-Thalassemia in Chorionic Villi Samples. [Journal Article]
- JCJ Clin Med 2019 Jun 05; 8(6)
- CONCLUSIONS: The metabolomics approach identified a specific metabolic fingerprint in chorionic villi of fetuses affected by β-thalassemia.
- Altered levels of placental miR-338-3p and miR-518b are associated with acute chorioamnionitis and IL6 genotype. [Journal Article]
- PPlacenta 2019; 82:42-45
- Placental-derived miRNAs are attractive candidates as biomarkers of placental health, but their associations with specific pathologies, such as acute chorioamnionitis (aCA), are not well explored. Sa…
Placental-derived miRNAs are attractive candidates as biomarkers of placental health, but their associations with specific pathologies, such as acute chorioamnionitis (aCA), are not well explored. Samples of chorionic villi from 57 placentas (33 aCA and 24 non-aCA) were analyzed. Expression was quantified for six candidate miRNAs (miR-146a, miR-210, miR-223, miR-338-3p, miR-411, and miR-518b), using quantitative real-time PCR. miR-518b and miR-338-3p were differentially expressed between aCA cases and non-aCA cases (Bonferroni-corrected p < 0.05). Further, we observed that placental miR-518b expression was associated with an IL6 SNP (rs1800796), a polymorphism we previously reported as a risk-conferring variant for aCA.
- Patterns of Placental Injury in Congenital Anomalies in Second Half of Pregnancy. [Journal Article]
- PDPediatr Dev Pathol 2019 May 28; :1093526619852869
- CONCLUSIONS: Fetal anomalies in second half of pregnancy feature abnormal clinical phenotypes much more frequently than abnormal placental phenotypes. Chromosomal abnormalities with or without heart malformations tend to feature villous edema, and erythroblastosis of fetal blood, likely due to fetal heart failure. Mass-forming fetal anomalies feature placental histological lesions of shallow placental implantation, diffuse chronic hypoxic patterns of placental injury, and lesions of fetal vascular malperfusion, likely stasis-induced.
- Loss of Placental P-Glycoprotein May Be a Common Pathophysiologic Pathway for First Trimester Spontaneous Miscarriages. [Journal Article]
- PDPediatr Dev Pathol 2019 May 24; :1093526619852874
- CONCLUSIONS: We report a dramatic loss/decrease of P-glycoprotein in first trimester spontaneous miscarriages. This finding in conjunction with the known high expression of P-glycoprotein in normal first trimester placental tissues suggests an important role of P-glycoprotein in the maintenance of early pregnancy.
- Downregulation of CCNA2 disturbs trophoblast migration, proliferation, and apoptosis during the pathogenesis of recurrent miscarriage. [Journal Article]
- AJAm J Reprod Immunol 2019; 82(1):e13144
- Recurrent miscarriage (RM) is defined as two or more pregnancy losses until 24 weeks of gestation, which distresses up to 1-5% of couples worldwide. Cyclin A2 (CCNA2) regulates the cell cycle by prom…
Recurrent miscarriage (RM) is defined as two or more pregnancy losses until 24 weeks of gestation, which distresses up to 1-5% of couples worldwide. Cyclin A2 (CCNA2) regulates the cell cycle by promoting transition through G1/S and G2/M. Little is known about CCNA2's functions in trophoblast, although it is highly expressed in the placenta. We therefore sought to explore the role of CCNA2 in RM and early pregnancy.
New Search Next
- [Genetic testing of chorionic villi from abortuses during early pregnancy]. [Journal Article]
- ZYZhonghua Yi Xue Yi Chuan Xue Za Zhi 2019 Jun 10; 36(6):547-551
- CONCLUSIONS: Chromosomal abnormalities are the main cause for early miscarriage, among which aneuploidies are most common. The prevalence of aneuploidies is significantly increased among women over 35. SNP-array analysis has the advantage of high success rate, high resolution and great accuracy, but the clinical significance of microdeletions/microduplications found by SNP-array can be difficult for interpretation.