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484,069 results
  • Deciphering ancestral sex chromosome turnovers based on analysis of male mutation bias. [Journal Article]
    Genome Biol Evol 2019Acosta A, Martínez-Pacheco ML, … Cortez D
  • The age of sex chromosomes is commonly obtained by comparing the substitution rates of XY gametologues. Coupled with phylogenetic reconstructions, one can refine the origin of a sex chromosome system relative to specific speciation events. However, these approaches are insufficient to determine the presence and duration of ancestral sex chromosome systems that were lost in some species. In this s…
  • Fitness consequences of the selfish supergene Segregation Distorter. [Journal Article]
    J Evol Biol 2019Wong HWS, Holman L
  • Segregation distorters are selfish genetic elements that subvert Mendelian inheritance, for example by destroying gametes that do not carry the distorter. Simple theoretical models predict that distorter alleles will either spread to fixation, or stabilise at some high intermediate frequency. However, many distorters have substantially lower allele frequencies than predicted by simple models, sug…
  • Actin-microtubule interplay coordinates spindle assembly in human oocytes. [Journal Article]
    Nat Commun 2019; 10(1):4651Roeles J, Tsiavaliaris G
  • Mammalian oocytes assemble a bipolar acentriolar microtubule spindle to segregate chromosomes during asymmetric division. There is increasing evidence that actin in the spindle interior not only participates in spindle migration and positioning but also protects oocytes from chromosome segregation errors leading to aneuploidy. Here we show that actin is an integral component of the meiotic machin…
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