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12,599 results
  • Drug Use Evaluation of Beta-Blockers in Medical Wards of Nedjo General Hospital, Western Ethiopia. [Journal Article]
    Cardiovasc Ther. 2020; 2020:2509875.Fekadu G, Bekele F, … Maqbool M
  • CONCLUSIONS: Overall, there was an inappropriate use of beta-blockers in terms of dosage and durations. So, prescribers of NGH should strictly adhere to the national treatment guideline when prescribing medications. Additionally, drug information centers have proved useful and effective in promoting rational drug use. Hence, it should be recommended for general use.
  • Efficient Drug Screening and Nephrotoxicity Assessment on Co-culture Microfluidic Kidney Chip. [Journal Article]
    Sci Rep. 2020 Apr 16; 10(1):6568.Yin L, Du G, … Yang SM
  • The function and susceptibility of various drugs are tested with renal proximal tubular epithelial cells; yet, replicating the morphology and kidneys function using the currently available in vitro models remains difficult. To overcome this difficulty, in the study presented in this paper, a device and a three-layer microfluidic chip were developed, which provides a simulated environment for kidn…
  • Dapsone as treatment adjunct in ARDS. [Journal Article]
    Exp Lung Res. 2020 May - Jun; 46(5):157-161.Kast RE
  • Multiple pharmacological interventions tested over the last decades have failed to reduce ARDS mortality. This short note recounts past data indicating that (i) neutrophils home along an IL-8 gradient, (ii) in ARDS, massive neutrophil accumulation and degranulation in and along bronchoalveolar spaces contributes to damage and hypoxia, (iii) large increases in IL-8 are one of the chemotaxic signal…
  • Muscular atrophy, impaired epithelial autophagy and UCHL1 increase in androgen-deficient cauda epididymis. [Journal Article]
    Reproduction. 2020 May; 159(6) Santi F, Lunardi ID, … Sasso-Cerri E
  • In epididymis, cimetidine induces androgenic failure due to reduced sex hormone-binding globulin stromal levels and blockade of androgen receptor (AR) nuclear import. UCHL1, a hydrolase of ubiquitin-proteasome system (UPS), seems to play a role in autophagy and apoptotic pathway. However, the role of UPS and autophagy in epididymis has not been clarified. We evaluated UCHL1 and autophagy in epidi…
  • Histamine receptors mediate contraction of reticular groove smooth muscle of adult goats. [Journal Article]
    Anat Histol Embryol. 2020 Mar 03 [Online ahead of print]Aneesha VA, Gopi RP, … Kumar D
  • The present study was conducted to evaluate the effect of histamine and to characterise its receptor subtypes in reticular groove (RG) smooth muscle of adult goats. The studies were done using floor and lip regions of RG. We used tension experiments on smooth muscle of RG isolated from adult goat for functional characterisation of H1 and H2 receptors. Western blotting and immunohistochemistry exp…
  • Relevance of Hydrogen Bonds for the Histamine H2 Receptor-Ligand Interactions: A Lesson from Deuteration. [Journal Article]
    Biomolecules. 2020 Jan 29; 10(2)Kržan M, Keuschler J, … Vianello R
  • We used a combination of density functional theory (DFT) calculations and the implicit quantization of the acidic N-H and O-H bonds to assess the effect of deuteration on the binding of agonists (2-methylhistamine and 4-methylhistamine) and antagonists (cimetidine and famotidine) to the histamine H2 receptor. The results show that deuteration significantly increases the affinity for 4-methylhista…
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