- Association of ultrasound-related interruption during cardiopulmonary resuscitation with adult cardiac arrest outcomes: A video-reviewed retrospective study. [Journal Article]Resuscitation 2020R
- CONCLUSIONS: Short ECHO-related interruption during CPR was positively associated with ROSC and survival to hospital discharge. While ECHO can be a valuable diagnostic tool during CPR, the no-flow time associated with ECHO should be minimized.
- The Value of Whole-Brain Perfusion Parameters Combined with Multiphase Computed Tomography Angiography in Predicting Hemorrhagic Transformation in Ischemic Stroke. [Journal Article]J Stroke Cerebrovasc Dis 2020; :104690JS
- CONCLUSIONS: Whole-brain perfusion parameters and MP-CTA scores have important application value in assessing the HT risk of ischemic stroke patients before treatment.
- Hotspot of dissimilatory nitrate reduction to ammonium (DNRA) process in freshwater sediments of riparian zones. [Journal Article]Water Res 2020; 173:115539WR
- Dissimilatory nitrate reduction to ammonium (DNRA), an important intermediate process in the N-cycle, links N-compound oxidation and reduction processes. Hence, the oxic-anoxic interface would be the hotspot of the DNRA process. In freshwater ecosystems, the riparian zone is the most typical carrier of the oxic-anoxic interface. Here we report spatio-temporal evidence of a higher abundance and ra…
Dissimilatory nitrate reduction to ammonium (DNRA), an important intermediate process in the N-cycle, links N-compound oxidation and reduction processes. Hence, the oxic-anoxic interface would be the hotspot of the DNRA process. In freshwater ecosystems, the riparian zone is the most typical carrier of the oxic-anoxic interface. Here we report spatio-temporal evidence of a higher abundance and rate of DNRA in the riparian zone than in the open water sediments based on molecular and 15N isotopic-tracing technologies, hence signifying a hotspot for the DNRA process. These abudance and rates were significantly higher than those in open water sediments. 15N isotopic paring technology revealed that the DNRA hotspot promoted higher rates of N-compound oxidation (NO2-), reduction (NO3- and DNRA), and N2 production (anammox and denitrification) in the riparian zone than those in open water sediment. However, high-through sequencing analysis showed that the DNRA bacteria in the riparian zone and openwater sediments were insignificantly different. Network and correlation analysis showed that the DNRA abundance and rates were significantly positively correlated with TOM, TC/NH4+, and TC/NO2-, but not with the dominant genera (Anaeromyxobacter, Lacunisphaera, and Sorangium), which played different roles on the connection in the respective community networks. The DNRA process in the riparian zone could be driven mainly by the related environmental biogeochemical characteristics induced by anthropogenic changes, followed by microbial processes. This result provides valuable information for the management of riparian zones because anthropogenic changes in the riparian water table are expected to increase, inducing consequent changes in the reduction from NO3- to NH4+.
- Aromatase Inhibitors and the Risk of Cardiovascular Outcomes in Women With Breast Cancer: A Population-Based Cohort Study. [Journal Article]Circulation 2020; 141(7):549-559Circ
- CONCLUSIONS: In this population-based study, aromatase inhibitors were associated with increased risks of heart failure and cardiovascular mortality compared with tamoxifen. There were also trends toward increased risks, although nonsignificant, of myocardial infarction and ischemic stroke. The increased risk of cardiovascular events associated with aromatase inhibitors should be balanced with their favorable clinical benefits compared with tamoxifen.
- Body Mass Index in Young Women and Risk of Cardiomyopathy: A Long-Term Follow-Up Study in Sweden. [Journal Article]Circulation 2020; 141(7):520-529Circ
- CONCLUSIONS: Elevated BMI among young women was associated with an increased risk of being diagnosed with a subsequent cardiomyopathy, especially dilated cardiomyopathy, starting already at mildly elevated body weight, whereas severe obesity entailed an almost 5-fold increase in risk. With the increasing numbers of persons who are overweight or obese, higher rates of cardiomyopathy can be expected in the future, along with an altered disease burden related to adiposity.
- Male origin microchimerism and ovarian cancer. [Journal Article]Int J Epidemiol 2020IJ
- CONCLUSIONS: For the first time we report that women who test positive for male microchimerism in their circulation have reduced rates of ovarian cancer compared with women who test negative. Although the underlying mechanisms are presently unknown, we believe male microchimerism is potent in preventing ovarian cancer.
- Ventilation time and prognosis after stroke thrombectomy: The shorter, the better! [Journal Article]Eur J Neurol 2020EJ
- CONCLUSIONS: Prolonged ventilation time after stroke thrombectomy independently predicts unfavorable outcome at three months and is associated with increased pneumonia rates. Therefore, extubation should be performed as early as safely possible.
- Emerging Role of Lymphatics in the Regulation of Intestinal Lipid Mobilization. [Review]Front Physiol 2019; 10:1604FP
- Intestinal handling of dietary triglycerides has important implications for health and disease. Following digestion in the intestinal lumen, absorption, and re-esterification of fatty acids and monoacylglycerols in intestinal enterocytes, triglycerides are packaged into lipoprotein particles (chylomicrons) for secretion or into cytoplasmic lipid droplets for transient or more prolonged storage. D…
Intestinal handling of dietary triglycerides has important implications for health and disease. Following digestion in the intestinal lumen, absorption, and re-esterification of fatty acids and monoacylglycerols in intestinal enterocytes, triglycerides are packaged into lipoprotein particles (chylomicrons) for secretion or into cytoplasmic lipid droplets for transient or more prolonged storage. Despite the recognition of prolonged retention of triglycerides in the post-absorptive phase and subsequent release from the intestine in chylomicron particles, the underlying regulatory mechanisms remain poorly understood. Chylomicron secretion involves multiple steps, including intracellular assembly and post-assembly transport through cellular organelles, the lamina propria, and the mesenteric lymphatics before being released into the circulation. Contrary to the long-held view that the intestinal lymphatic vasculature acts mainly as a passive conduit, it is increasingly recognized to play an active and regulatory role in the rate of chylomicron release into the circulation. Here, we review the latest advances in understanding the role of lymphatics in intestinal lipid handling and chylomicron secretion. We highlight emerging evidence that oral glucose and the gut hormone glucagon-like peptide-2 mobilize retained enteral lipid by differing mechanisms to promote the secretion of chylomicrons via glucose possibly by mobilizing cytoplasmic lipid droplets and via glucagon-like peptide-2 possibly by targeting post-enterocyte secretory mechanisms. We discuss other potential regulatory factors that are the focus of ongoing and future research. Regulation of lymphatic pumping and function is emerging as an area of great interest in our understanding of the integrated absorption of dietary fat and chylomicron secretion and potential implications for whole-body metabolic health.
- Effectiveness and Safety of Percutaneous Thrombectomy Devices: Comparison of Rotarex and Angiojet in a Physiological Circulation Model. [Journal Article]Eur J Vasc Endovasc Surg 2020EJ
- CONCLUSIONS: Both devices showed a comparable performance, with a slight advantage for the Rotarex regarding first pass recanalisation. Significantly more thrombo-emboli, and vascular injuries were observed in the Rotarex group with the latter being obviously the more tissue preserving procedure but potentially with a lower rate of recanalisation. Based on the present results, clinical randomised trials, including long term follow up, are needed to optimise and improve the use of catheter based procedures, taking into account the thrombus entity, localisation, and clinical history.
New Search Next
- Do Sex Differences Exist in the Establishment of "Do Not Attempt Resuscitation" Orders and Survival in Patients Successfully Resuscitated From In-Hospital Cardiac Arrest? [Journal Article]J Am Heart Assoc 2020; 9(4):e014200JA
- Background Women have higher utilization of "do not attempt resuscitation" (DNAR) orders during treatment for critical illness. Occurrence of sex differences in the establishment of DNAR orders after resuscitation from in-hospital cardiac arrest is unknown. Whether differences in DNAR use by sex lead to disparities in survival remains unclear. Methods and Results We identified 71 820 patients wit…
Background Women have higher utilization of "do not attempt resuscitation" (DNAR) orders during treatment for critical illness. Occurrence of sex differences in the establishment of DNAR orders after resuscitation from in-hospital cardiac arrest is unknown. Whether differences in DNAR use by sex lead to disparities in survival remains unclear. Methods and Results We identified 71 820 patients with return of spontaneous circulation (ROSC) after in-hospital cardiac arrest from the Get With The Guidelines-Resuscitation registry. Multivariable models evaluated the association between de novo DNAR (anytime after ROSC, within 12 hours of ROSC, or within 72 hours of ROSC) by sex and the association between sex and survival to discharge accounting for DNAR. All models accounted for clustering of patients within hospital and adjusted for demographic and cardiac arrest characteristics. The cohort included 30 454 (42.4%) women, who were slightly more likely than male participants to establish DNAR orders anytime after ROSC (45.0% versus 43.5%; adjusted relative risk: 1.15 [95% CI, 1.10-1.20]; P<0.0001). Of those with DNAR orders, women were more likely to be DNAR status within the first 12 hours (51.8% versus 46.5%; adjusted relative risk: 1.40 [95% CI, 1.30-1.52]; P<0.0001) and within 72 hours after ROSC (75.9% versus 70.9%; adjusted relative risk: 1.35 [95% CI, 1.26-1.45]; P<0.0001). However, no difference in survival to hospital discharge between women and men (34.5% versus 36.7%; adjusted relative risk: 1.00 [95% CI, 0.99-1.02]; P=0.74) was appreciated. Conclusions In patients successfully resuscitated from in-hospital cardiac arrest, there was no survival difference between men and women while accounting for DNAR. However, women had a higher rate of DNAR status early after resuscitation (<12 and <72 hours) in comparison to men.