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21,755 results
  • Characteristics of three microbial colonization states in the duodenum of the cirrhotic patients. [Journal Article]
    Future Microbiol. 2020 Jul 14 [Online ahead of print]Zha H, Chen Y, … Li L
  • Aim: Investigation of characteristics of different duodenal microbial colonization states in patients with liver cirrhosis (LC). Materials & methods: Deep-sequencing analyses of the 16S rRNA gene V1-V3 regions were performed. Results: Both bacterial compositions and richness were different between the three clustered LC microbiotas, in other words, Cluster_1_LC, Cluster_2_LC and Cluster_3_LC. C…
  • Novel therapeutics for portal hypertension and fibrosis in chronic liver disease. [Review]
    Pharmacol Ther. 2020 Jul 10 [Online ahead of print]Guixé-Muntet S, Zhu CP, … Gracia-Sancho J
  • Portal hypertension (PH) is the most common non-neoplastic complication of chronic liver disease, determining clinical complications that lead to death or liver transplantation. PH results from increased resistance to portal blood flow through the cirrhotic liver, which is due to hepatic fibrosis and microcirculatory dysfunction. The present review focuses on the pathophysiology of fibrosis and P…
  • Color Doppler Ultrasound in Portal Hypertension: A Closer Look at Left Gastric Vein Hemodynamics. [Review]
    J Ultrasound Med. 2020 Jul 13 [Online ahead of print]Cannella R, Giambelluca D, … Cabassa P
  • Portal hypertension is one of the most important causes of morbidity and mortality in cirrhotic patients. A color Doppler evaluation of the left gastric vein (LGV) has proven utility in the prediction of esophageal varices and variceal bleeding in patients with portal hypertension. The purpose of this review is to discuss the ultrasound evaluation, imaging findings, and clinical application of Do…
  • Non-invasive tests for the prediction of primary hepatocellular carcinoma. [Review]
    World J Gastroenterol. 2020 Jun 28; 26(24):3326-3343.Marasco G, Colecchia A, … Festi D
  • Hepatocellular carcinoma (HCC) is one of the most common malignancies in the world and it is one of the main complications of cirrhosis and portal hypertension. Even in the presence of a well-established follow-up protocol for cirrhotic patients, to date poor data are available on predictive markers for primary HCC occurrence in the setting of compensated advanced chronic liver disease patients (…
  • Intraabdominal urokinase in the treatment of loculated infected ascites in cirrhosis. [Case Reports]
    Clin Res Hepatol Gastroenterol. 2020 Jul 09 [Online ahead of print]Tripon S, Mayer P, … Enescu I
  • Cirrhotic patients may present loculated ascites. We report a case of a 49-years old patient with cirrhosis and loculated infected ascites. Conventional and ultrasound (US)-guided paracentesis were ineffective. Moreover, US-guided drainages with 10 F drains could drain only small quantities of ascites localized in the largest loculated areas. Despite an adapted and long antibiotic therapy, the in…
  • Trends and outcomes of Peptic Ulcer Disease in patients with Cirrhosis. [Journal Article]
    Postgrad Med. 2020 Jul 11 [Online ahead of print]Shah H, Yang TJ, … Aronow W
  • CONCLUSIONS: Our study shows that there is an increased hospital burden as well as poor outcomes in terms of higher in-hospital mortality among hospitalized PUD patients with cirrhosis. Further studies are warranted for better risk stratification and improvement of outcomes.
  • Liver resection in Cirrhotic liver: Are there any limits? [Editorial]
    Int J Surg. 2020 Jul 08 [Online ahead of print]Chan A, Kow A, … Serrablo A
  • Liver resection remains one of the most technically challenging surgical procedure in abdominal surgery due to the complex anatomical arrangement in the liver and its rich blood supply that constitutes about 20% of the cardiac output per cycle. The challenge for resection in cirrhotic livers is even higher because of the impact of surgical stress and trauma imposed on borderline liver function an…
  • Cirrhotic Cardiomyopathy. [Review]
    Curr Gastroenterol Rep. 2020 Jul 10; 22(9):45.Yoon KT, Liu H, Lee SS
  • Cirrhotic cardiomyopathy is a syndrome of depressed cardiac function in patients with cirrhosis. We aimed to review the historical background, pathophysiology and pathogenesis, diagnostic definitions, clinical relevance, and management of this syndrome.
  • Role of B Cell Lymphoma 2 in the Regulation of Liver Fibrosis in miR-122 Knockout Mice. [Journal Article]
    Biology (Basel). 2020 Jul 08; 9(7)Teng KY, Barajas JM, … Ghoshal K
  • MicroRNA-122 (miR-122) has been identified as a marker of various liver injuries, including hepatitis- virus-infection-, alcoholic-, and non-alcoholic steatohepatitis (NASH)-induced liver fibrosis. Here, we report that the extracellular miR-122 from hepatic cells can be delivered to hepatic stellate cells (HSCs) to modulate their proliferation and gene expression. Our published Argonaute crosslin…
  • Motor and Cognitive Performance in Patients with Liver Cirrhosis with Minimal Hepatic Encephalopathy. [Journal Article]
    J Clin Med. 2020 Jul 08; 9(7)San Martín-Valenzuela C, Borras-Barrachina A, … Montoliu C
  • Minimal hepatic encephalopathy (MHE) is associated with mild cognitive impairment and frailty. This study aims to identify cognitive and motor differences in cirrhotic patients with and without MHE, and the correlations between motor signs and cognitive performance. Gait, balance, hand strength and motor speed performance were evaluated in 66 cirrhotic patients (38 without and 28 with MHE, accord…
  • StatPearls: Ethacrynic Acid [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Aribo Chade C UC Riverside Ng Daniel K. DK University of California Riverside BOOK
  • Ethacrynic acid is a loop diuretic that gained FDA approval for widespread use in 1967. Unlike other loop diuretics, ethacrynic acid is a novel drug due to the absence of a sulfonamide group in its structure, allowing its use in critically ill patients with life-threatening sulfa-allergies.[1] In adults, ethacrynic acid is a choice for the relief of edema in patients with renal failure, congestiv…
  • StatPearls: Sengstaken-Blakemore Tube [BOOK]
    . StatPearls Publishing: Treasure Island (FL) Powell Mollie M North Florida Regional Medical Center Journey Jonathan D. JD Un of Central Florida/North Florida RMC BOOK
  • In 1950 Robert W. Sengstaken and Arthur H. Blakemore recognized that the introduction of blood banks and the ability to provide patients with large quantities of blood quickly was saving lives, especially in cases of hemorrhaging esophageal varices, but transfusion alone was not sufficient. Many patients who present with esophageal varices also have liver cirrhosis. Cirrhotic livers, in general, …
  • Measurement of the Hepatic Venous Pressure Gradient and Transjugular Liver Biopsy. [Journal Article]
    J Vis Exp. 2020 Jun 18Reiberger T, Schwabl P, … Mandorfer M
  • Here we provide a detailed protocol describing the clinical procedure of hepatic venous pressure gradient (HVPG) measurement in patients with advanced chronic liver disease followed by an instruction for transjugular biopsy. Under local anesthesia and ultrasound guidance, a catheter introducer sheath is placed in the right internal jugular vein. Using fluoroscopic guidance, a balloon catheter is …
  • Cirrhosis in Wilson Disease is characterized by Impaired Hepatic Synthesis, Leukopenia and Thrombocytopenia. [Journal Article]
    Int J Med Sci. 2020; 17(10):1345-1350.Zhong HJ, Xiao P, … He XX
  • Background: Patients with Wilson disease (WD) progress to cirrhosis at an early age but have good prognoses. This study aimed to delineate hepatic features in WD patients with or without cirrhosis. Methods: Medical data were retrospectively collected from 27 July 2015 to 27 June 2018. WD patients were divided into two groups based on whether or not they progressed to cirrhosis. Liver function, …
  • Benign Neoplasms, Mass-Like Infections, and Pseudotumors That Mimic Hepatic Malignancy at MRI. [Journal Article]
    J Magn Reson Imaging. 2020 Jul 04 [Online ahead of print]Costa AF, Clarke SE, … Thipphavong S
  • A variety of conditions may mimic hepatic malignancy at MRI. These include benign hepatic tumors and tumor-like entities such as focal nodular hyperplasia-like lesions, hepatocellular adenoma, hepatic infections, inflammatory pseudotumor, vascular entities, and in the cirrhotic liver, confluent fibrosis, and hypertrophic pseudomass. These conditions demonstrate MRI features that overlap with hepa…
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