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449 results
  • Kappa opioid receptor and oligodendrocyte remyelination. [Journal Article]
    Vitam Horm 2019; 111:281-297Wang F, Mei F
  • Adult oligodendrocyte precursor cells (OPCs) maintain the abilities to differentiate and myelinate denuded axons in demyelinating diseases, such as Multiple Sclerosis (MS), albert often inefficiently. Remyelination therapies seek to enhance endogenous remyelination and represent a promising approach to achieve functional and cellular architectural recovery against neuronal deficits. Recent findin…
  • Approaches to Remyelination Therapies in Multiple Sclerosis. [Review]
    Curr Treat Options Neurol 2019; 21(7):34Wooliscroft L, Silbermann E, … Bourdette D
  • While there are a growing number of therapies targeting relapse prevention in multiple sclerosis (MS), there are no approved therapies promoting remyelination. Understanding endogenous myelin formation, remyelination strategies, pre-clinical models, and clinical outcomes is essential to the interpretation of current and future clinical trials of remyelinating agents.
  • Anaphylactic Reaction to Tc-99m Macrosalb. [Journal Article]
    Drug Saf Case Rep 2019; 6(1):4Schreuder N, de Hoog Q, … van Puijenbroek EP
  • A 49-year-old woman developed an anaphylactic reaction to Tc-99m macrosalb used for pulmonary scintigraphy. The patient received an intravenous injection of Tc-99m macrosalb 120 MBq, containing macroaggregates of human albumin 0.14 mg. Within 1 min she developed itching all over her body, an itching throat and dyspnoea. This was followed by urticaria and facial oedema. She was diagnosed with an a…
  • Potentiation of P2RX7 as a host-directed strategy for control of mycobacterial infection. [Journal Article]
    Elife 2019; 8Matty MA, Knudsen DR, … Tobin DM
  • Mycobacterium tuberculosis is the leading worldwide cause of death due to a single infectious agent. Existing anti-tuberculous therapies require long treatments and are complicated by multi-drug-resistant strains. Host-directed therapies have been proposed as an orthogonal approach, but few have moved into clinical trials. Here, we use the zebrafish-Mycobacterium marinum infection model as a whol…
  • Multimodal Enhancement of Remyelination by Exercise with a Pivotal Role for Oligodendroglial PGC1α. [Journal Article]
    Cell Rep 2018; 24(12):3167-3179Jensen SK, Michaels NJ, … Yong VW
  • Remyelination is a multistep regenerative process that results in the reformation of myelin sheaths around demyelinated axons and is a critical therapeutic target. Here we show that immediate access to a running wheel following toxin-induced demyelination in mice enhances oligodendrogenesis, the rate of remyelination, and the proportion of remyelinated axons. RNA sequencing suggests broad activat…
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