- Methylenetetrahydrofolate reductase polymorphisms and colorectal cancer prognosis: a meta-analysis. [Review]
- JGJ Gene Med 2019 Jul 22; :e3114
- CONCLUSIONS: The MTHFR rs1801133 polymorphism was not associated with the prognosis of patients with CRC; however, rs1801131 may be associated with the prognosis of patients with CRC. Well-designed prospective studies are necessary to obtain a better understanding of the prognostic value of rs1801133 and rs1801131.
- The accuracy of computer guided implant surgery with tooth supported, digitally designed drill guides based on CBCT and intraoral scanning. A prospective cohort study. [Journal Article]
- COClin Oral Implants Res 2019 Jul 22
- CONCLUSIONS: Guided surgery with tooth-supported drill guides made in a digital workflow is a feasible treatment option. However, deviations do occur and the implant's length, location, cortical interference and the amount of unrestored teeth have a significant influence on the accuracy. This article is protected by copyright. All rights reserved.
- Modified interpersonal and social rhythm therapy via modulation of ambient light. [Journal Article]
- BDBipolar Disord 2019 Jul 22
- Interpersonal and social rhythm therapy (IPSRT) is an effective psychotherapy approach for long-term management of bipolar disorder.1 The main purpose of IPSRT is to regularize social and biological …
Interpersonal and social rhythm therapy (IPSRT) is an effective psychotherapy approach for long-term management of bipolar disorder.1 The main purpose of IPSRT is to regularize social and biological daily rhythms in order to promote mood stability and facilitate good sleep. The patients are required to record daily activities (e.g., time out of bed, first contact with another person, meal times, bedtime) on the Social Rhythm Metric (SRM).1 The SRM is useful for monitoring the dynamic interplay among instabilities in daily routines, patterns of social stimulation, sleep-wake times, and mood fluctuations. However, the SRM does not attach importance to the effect of ambient light. This article is protected by copyright. All rights reserved.
- Basement membrane zone IgE deposition is associated with bullous pemphigoid disease severity and treatment results. [Journal Article]
- BJBr J Dermatol 2019 Jul 22
- CONCLUSIONS: IgE deposition in the BMZ is associated with higher E/B BPDAI scores and longer treatment periods. We conclude that IgE binding in the BMZ may contribute to BP pathogenesis by promoting blister formation. This article is protected by copyright. All rights reserved.
- Optic Neuropathy, Secondary to Ethmoiditis, and Onodi Cell Inflammation during Childhood: A Case Report and Review of the Literature. [Journal Article]
- NNeuropediatrics 2019 Jul 22
- Optic neuropathy consists of several etiological events. The primary etiologies of its acute form include optic neuritis, ischemic optic neuropathy, inflammatory (nondemyelinating) disorders, and tra…
Optic neuropathy consists of several etiological events. The primary etiologies of its acute form include optic neuritis, ischemic optic neuropathy, inflammatory (nondemyelinating) disorders, and trauma. Its subacute and chronic forms are most often linked to compressive, toxic, nutritional, or hereditary-genetic causes. Visual loss, dyschromatopsia, and visual field defects are the presenting symptoms. The Onodi cell (sphenoethmoidal air cell) is an anatomic variant located laterally and superior to the sphenoid sinus; it is closely related to the optic nerve. Onodi cell disorders are rare and may be unnoticed in differential diagnoses of patients with ocular and neurological manifestations. Here, we present the case of a 12-year-old boy with headache and acute loss of sight characterized by hemianopsia in the left eye and retrobulbar optic neuropathy caused by left sphenoethmoidal sinusitis with the presence of Onodi cell inflammation. The diagnosis was confirmed by multilayered paranasal computed tomography and cerebral magnetic resonance imaging. Therapeutic treatment resulted in gradual improvement: at the 2-week follow-up, the patient no longer had headaches and his visual acuity returned to normal. Inflammation of Onodi cells should be considered in children with headache and abnormal vision.
- Total Thrombus-Formation Analysis System (T-TAS): Clinical Application of Quantitative Analysis of Thrombus Formation in Cardiovascular Disease. [Journal Article]
- THThromb Haemost 2019 Jul 22
- Various antithrombotic agents are clinically used to inhibit the cascade of arterial or venous thrombosis in cardiovascular diseases. Dual antiplatelet therapy with aspirin and P2Y12 inhibitors is pr…
Various antithrombotic agents are clinically used to inhibit the cascade of arterial or venous thrombosis in cardiovascular diseases. Dual antiplatelet therapy with aspirin and P2Y12 inhibitors is prescribed in patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). Direct oral anticoagulants (DOACs) are widely used for the prevention or treatment of thromboembolism in patients with atrial fibrillation (AF) and venous thromboembolism. However, there has been no definitive tool to simultaneously monitor the antithrombotic effects of these drugs. The Total Thrombus-Formation Analysis System (T-TAS), a microchip-based flow chamber system that mimics in vivo conditions for evaluating whole blood thrombogenicity, was developed for the quantitative analysis of thrombus formation in whole blood specimens. The utility of T-TAS has been evaluated in CAD patients treated with antiplatelet therapies. The T-TAS PL chip area under the flow pressure curve (AUC) accurately assesses primary hemostasis and is sensitive to the therapeutic effects of various antiplatelet therapies. In addition, low AUC results are a significant predictor of periprocedural bleeding events in CAD patients undergoing PCI. The T-TAS AR chip AUC result is useful for assessing the efficacy of DOACs and warfarin in AF patients undergoing catheter ablation, and it is also a potential independent predictor of periprocedural bleeding events and avoidance of thrombosis in patients having undergone total knee arthroplasty. In conclusion, T-TAS is a useful index for evaluating the total antithrombotic effects of combination antithrombotic agents in patients with various cardiovascular diseases.
- Outcomes of surgical resections for benign colon polyps: a systematic review. [Journal Article]
- EEndoscopy 2019 Jul 22
- CONCLUSIONS: The postoperative morbidity and mortality after colonic resection for benign polyps are substantial. Referral to an advanced interventional endoscopist should be considered before referral for surgery to evaluate the possibilities for endoscopic treatment of large, non-pedunculated, and/or colonic polyps in difficult locations without suspicion of submucosal malignant invasion.
- Combined versus single use 20 G fine-needle biopsy and 25 G fine-needle aspiration for endoscopic ultrasound-guided tissue sampling of solid gastrointestinal lesions. [Clinical Trial]
- EEndoscopy 2019 Jul 22
- CONCLUSIONS: Dual sampling only improved diagnostic accuracy when 25 G FNA was followed by 20 G FNB and not vice versa. As the diagnostic benefit of the 20 G FNB over the 25 G FNA needle has recently been proven, sampling with the FNB needle seems a logical first choice.
- Omitting Chest Tube Drainage after Subxiphoid Thoracoscopic Thymectomy. [Journal Article]
- TCThorac Cardiovasc Surg 2019 Jul 22
- CONCLUSIONS: The omission of chest tube drainage may be an alternative procedure for selected patients undergoing thoracoscopic thymectomy. The omission of chest tubes in thymectomy is safe, but further investigation is required.
New Search Next
- Aortic Valve-Sparing Root Replacement (David I Procedure) in Adolescents: Long-Term Outcome. [Journal Article]
- TCThorac Cardiovasc Surg 2019 Jul 22
- CONCLUSIONS: Aortic valve-sparing root replacement can be performed in adolescents with a very low perioperative risk. Long-term survival seems to be affected by connective tissue diseases.