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(clinically isolated syndrome)
2,549 results
  • Cortical quantitative MRI parameters are related to the cognitive status in patients with relapsing-remitting multiple sclerosis. [Journal Article]
    Eur Radiol 2019van Wijnen A, Petrov F, … Gracien RM
  • CONCLUSIONS: Microstructural changes are distributed heterogeneously across the cortex in RRMS/CIS. QMRI has the potential to provide surrogate parameters for the assessment of cognitive impairment in these patients for clinical studies. The characteristics of cognitive impairment in RRMS might depend on the distribution of cortical changes.• The goal of the presented study was to investigate cortical changes in RRMS/CIS and their relation to the cognitive status, using multiparametric quantitative MRI. • Cortical T2, T2*, and PD increases observed in patients appeared heterogeneous across the cortex and their distribution differed between the parameters. • Vertex-wise correlation of T2 with neuropsychological scores revealed specific patterns of cortical changes being related to distinct cognitive deficits.
  • The cause and pathogenesis of hemolytic transfusion reactions in sickle-cell disease. [Journal Article]
    Curr Opin Hematol 2019; 26(6):488-494Pirenne F
  • CONCLUSIONS: Hemolytic transfusion reactions are the most feared complications of blood transfusion in patients with SCD. This reaction is underdiagnosed because it mimics a vaso-occlusive crisis. Alloimmunization against red blood cell antigens is known to be a major trigger of this reaction, but abnormal complement activation and the underlying condition in patients with chronic hemolysis, may amplify the reaction. There is an urgent need to develop evidence-based approaches for preventing and treating this reaction.
  • MOG-Ab prevalence in optic neuritis and clinical predictive factors for diagnosis. [Journal Article]
    Br J Ophthalmol 2019Ducloyer JB, Caignard A, … Lebranchu P
  • CONCLUSIONS: Among ON episodes, MOG-Ab were found in 14% of cases. MOG+ON occurred without female preponderance and was significantly associated with ODS and/or bilateral ON. Testing MOG-Ab only in patients presenting with ODS or bilateral or recurrent ON would limit MOG-Ab tests to fewer than half of all patients without the risk of missing any MOG+ON cases.
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