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1,042 results
  • Complete Atlantoaxial Dislocation After Odontoid Synchondrosis Fracture: A 2-Year Follow-up Study: A Case Report. [Journal Article]
  • JCJBJS Case Connect 2019 Apr-Jun; 9(2):e0327
  • Karamian BA, Campbell ST, Rinsky LA
  • CONCLUSIONS: The case presented demonstrates one option for an otherwise nonreducible odontoid synchondrosis fracture with complete atlantoaxial dislocation: transoral reduction and open posterior instrumentation. This proved to be a practical technique and provided a good clinical result in this case. These injuries are rare, but when they do occur, the examination can be surprisingly subtle given the severity of the injury. Plain films should be scrutinized carefully and advanced imaging obtained when necessary to confirm the diagnosis.
  • The loss of slow skeletal muscle isoform of troponin T in spindle intrafusal fibres explains the pathophysiology of Amish nemaline myopathy. [Journal Article]
  • JPJ Physiol 2019 May 31
  • Oki K, Wei B, … Jin JP
  • CONCLUSIONS: The pathogenic mechanism and the neuromuscular reflex-related phenotype (e.g. tremors accompanied by clonus) of Amish nemaline myopathy, as well as of other recessively inherited TNNT1 myopathies, remain to be clarified. The truncated slow skeletal muscle isoform of troponin T (ssTnT) encoded by the mutant TNNT1 gene is unable to incorporate into myofilaments and is degraded in muscle cells. By contrast to extrafusal muscle fibres, spindle intrafusal fibres of normal mice contain a significant level of cardiac TnT and a low molecular weight splice form of ssTnT. Intrafusal fibres of ssTnT-knockout mice have significantly increased cardiac TnT. Rotarod and balance beam tests have revealed abnormal neuromuscular co-ordination in ssTnT-knockout mice and a blunted response to a spindle sensitizer, succinylcholine. The loss of ssTnT and a compensatory increase of cardiac TnT in intrafusal nuclear bag fibres may increase myofilament Ca2+ -sensitivity and tension, impairing spindle function, thus identifying a novel mechanism for the development of targeted treatment.
  • Defining the spectrum of spasticity-associated involuntary movements. [Journal Article]
  • PRParkinsonism Relat Disord 2019 May 12
  • Abboud H, Macaron G, … Bethoux F
  • CONCLUSIONS: Most spastic patients experience spasticity-associated involuntary movements of variable phenomenology and impact. However, only half of these patients experience significant improvement with the current management strategies. More research is needed to explore better treatment options for spasticity-associated involuntary movements with focus on phenomenology-specific approaches.
  • StatPearls: Neuroanatomy, Upper Motor Nerve Signs [BOOK]
  • BOOKStatPearls Publishing: Treasure Island (FL)
  • Emos Marc Christopher MC SUNY Downstate Medical Center Rosner Julie J Lewis Katz School of Medicine
  • The initiation and coordination of movement are under the control of an immense network of nerves in the central nervous system (CNS) that originate from the cerebral cortex and course through the in…
  • Spinal Cord Diffuse Midline Glioma in a 4-Year-Old Boy. [Case Reports]
  • CNChild Neurol Open 2019; 6:2329048X19842451
  • Kumar A, Rashid S, … Dure LS
  • CONCLUSIONS: High-grade spinal cord gliomas are very rare but should be considered in the differential diagnosis of pediatric myelopathy. Tissue biopsy is recommended in indeterminate cases to facilitate diagnosis and to guide management.
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