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1,050 results
  • Functional Outcome of Adulthood Selective Dorsal Rhizotomy for Spastic Diplegia. [Journal Article]
    Cureus 2019; 11(7):e5184Park TS, Uhm SY, … Dobbs MB
  • Objective The medical evidence supporting the efficacy of selective dorsal rhizotomy (SDR) on children with spastic diplegia is strong. However, the outcome of SDR on adults with spastic diplegia remains undetermined. The aim is to study the effectiveness and morbidities of SDR performed on adults for the treatment of spastic diplegia. Methods Patients who received SDR in adulthood for the treatm…
  • Successful use of carbamazepine in a patient with drug rash with eosinophilia and systemic symptoms. [Case Reports]
    Ment Health Clin 2019; 9(5):331-335Bixby AL, Goldsborough S, … VandenBerg A
  • Drug rash with eosinophilia and systemic symptoms (DRESS) is a serious adverse drug reaction with a high mortality rate. Discontinuation of the causative agent is the primary treatment. History of DRESS may put patients at higher risk of future episodes; however, cross-reactivity between various medications is not well established. An 18-year-old African American male with a history of bipolar I …
  • Hepatic arginase deficiency fosters dysmyelination during postnatal CNS development. [Journal Article]
    JCI Insight 2019; 4(17)Liu XB, Haney JR, … Lipshutz GS
  • Deficiency of arginase is associated with hyperargininemia, and prominent features include spastic diplegia/tetraplegia, clonus, and hyperreflexia; loss of ambulation, intellectual disability and progressive neurological decline are other signs. To gain greater insight into the unique neuromotor features, we performed gene expression profiling of the motor cortex of a murine model of the disorder…
  • Modulation of soleus stretch reflexes during walking in people with chronic incomplete spinal cord injury. [Journal Article]
    Exp Brain Res 2019; 237(10):2461-2479Thompson AK, Mrachacz-Kersting N, … Andersen JB
  • In people with spasticity due to chronic incomplete spinal cord injury (SCI), it has been presumed that the abnormal stretch reflex activity impairs gait. However, locomotor stretch reflexes across all phases of walking have not been investigated in people with SCI. Thus, to understand modulation of stretch reflex excitability during spastic gait, we investigated soleus stretch reflexes across th…
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