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13,765 results
  • Antithrombotic therapy in patients with atrial fibrillation undergoing coronary artery stenting. [Journal Article]
    Am J Health Syst Pharm 2019; 76(18):1395-1402Lacoste JL, Hansen CL
  • CONCLUSIONS: A review of current literature on antithrombotic therapy in patients with AF undergoing PCI and subsequent coronary artery stenting indicates that the favored regimen is dual therapy consisting of clopidogrel with rivaroxaban, apixaban, dabigatran, or a vitamin K antagonist. Aspirin may be used in the periprocedural period but should be discontinued thereafter to reduce the risk of bleeding. Decisions regarding specific agents and duration of treatment should be based on thrombotic risk, bleeding risk, and patient preference.
  • Microvesicles from patients with acute coronary syndrome enhance platelet aggregation. [Journal Article]
    Scand J Clin Lab Invest 2019; :1-6Kafian S, Wallén H, … Mobarrez F
  • Microvesicles (MVs) released from leukocytes, platelets and endothelial cells are elevated in patients with acute coronary syndrome (ACS). In the present study, we assessed the potential pro-aggregatory properties of MVs obtained from ACS patients. Thus, we divided the patients into two groups based on clopidogrel-responsiveness, i.e. high on-treatment platelet reactivity (HPR; n = 16), and low o…
  • Advances in the Pharmacogenomics of Antiplatelet Therapy. [Journal Article]
    Am J Ther 2019Akhtar T, Bandyopadhyay D, … Yadav N
  • CONCLUSIONS: Genotype-guided selection of antiplatelet therapy is expected to be useful in patients undergoing percutaneous coronary intervention (PCI) with a high risk of adverse outcomes. The patient-physician discussion should be an essential part of this decision-making process. Large-scale multicenter randomized controlled trials using the point-of-care genotype assay are needed to investigate this approach further before its use can be recommended in all comers.
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