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470 results
  • Making Rash Decisions in Epilepsy: Evaluating Hypersensitivity Reactions to Anti-seizure Medications. [Journal Article]
    Epilepsy Curr 2019 Mar-Apr; 19(2):96-98Bermeo-Ovalle A
  • CONCLUSIONS: Although allergic reactions to AEDs are rare, they are of significance because they can cause life-threatening severe cutaneous drug reactions. Therefore, patients receiving AEDs, especially aromatic AEDs, must be monitored closely. Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis With Antiepileptic Drugs: An Analysis of the US Food and Drug Administration Adverse Event Reporting System Borrelli EP, Lee EY, Descoteaux AM, Kogut SJ, Caffrey AR. Epilepsia. 2018;59(12):2318-2324.Although AEDs as a class were associated with 9 times the risk of SJS/TEN compared with non-AEDs, there were 6 AEDs with risk estimates greater than 20. Increased awareness of this risk among both prescribers and patients, particularly variations in risk among different AEDs, along with education on early recognition of SJS/TEN signs/symptoms, may help mitigate the number and severity of these adverse events.
  • StatPearls: Prescription of Controlled Substances: Benefits and Risks [BOOK]
    StatPearls Publishing: Treasure Island (FL) Preuss Charles V. CV University of South Florida Kalava Arun A University of South Florida King Kevin C. KC Geisinger Wyoming Valley Medical Center BOOK
  • One of the single most difficult challenges for any prescriber is to distinguish between the legitimate prescription of controlled substances versus the prescription potentially used for illegitimate purposes. To discern the difference prescribers need to understand the signs, symptoms, and treatment of acute and chronic pain as well as the signs and symptoms of patients using controlled substanc…
  • Intellectual Disability and Psychotropic Medications. [Journal Article]
    J Dev Behav Pediatr 2018; 39(7):591-593Herzig L, de Lacy N, … Radesky J
  • Andrew is a 17-year-old male with trisomy 21, commonly known as Down syndrome, and accompanying severe intellectual disability who presents to your primary care office with his father for the first time to establish care and assistance with transition. Andrew has a history of a complete atrioventricular canal that was repaired as an infant and poorly controlled infantile spasms. Currently, he str…
  • Drugs and Lactation Database (LactMed): Clorazepate [BOOK]
    National Library of Medicine (US): Bethesda (MD)BOOK
  • Clorazepate is excreted into breastmilk and appears to accumulate in the serum of breastfed infants. Because the half-life of clorazepate and its active metabolite are long, timing breastfeeding with respect to the dose is of little or no benefit in reducing infant exposure. Other agents may be preferred, especially while nursing a newborn or preterm infant.
  • Tamper-resistant prescription forms for narcotics in France: Should we generalize them? [Journal Article]
    Fundam Clin Pharmacol 2018; 32(5):571-577Daveluy A, Sauvaget L, … Haramburu F
  • In France, prescription of narcotics must be written on a tamper-resistant prescription form with specific technical particularities. Dosage and daily dose of medicines shall be written out entirely in letters. These prescription forms are also mandatory for buprenorphine, clorazepate, clonazepam, tianeptine, buccal midazolam and zolpidem owing to traffic, abuse or diversion. In 2012, to assess t…
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