- StatPearls: Aspergilloma [BOOK]StatPearls Publishing: Treasure Island (FL)BOOK
- Inert saprophytic colonization of preexisting cavitary spaces in pulmonary parenchyma, its presentation, as well as complications thereof, are referred to as aspergilloma. It falls within the broader class of chronic pulmonary aspergillosis. A cavitary space with well-defined walls sequesters the fungal spores from both mechanical clearance, as well as immune eradication. Description of cavitary …
Inert saprophytic colonization of preexisting cavitary spaces in pulmonary parenchyma, its presentation, as well as complications thereof, are referred to as aspergilloma. It falls within the broader class of chronic pulmonary aspergillosis. A cavitary space with well-defined walls sequesters the fungal spores from both mechanical clearance, as well as immune eradication. Description of cavitary aspergillus disease dates back to John Hughes Bennett in 1842, whose description of soft tuberculous matter in multiple varied sized cavities in the lung closely resembles aspergillus disease. Deve in 1938 first formally described an aspergilloma and named it as “ mega mycetoma.” Subsequently Hinson and colleagues defined aspergilloma in its currently understood version of a saprophytic infection of preexisting lung cavities. Belcher and Plummer first formulated the classification of aspergilloma in 1960. If the surrounding lung parenchyma appeared normal and the cavity containing the aspergillus nidus was entirely lined by ciliated epithelium, it was termed as a simple aspergilloma. On the other hand, a complex aspergilloma is one lined by extensively damaged surrounding lung parenchyma with epithelial distortion or destruction and fibrosis. Wall thickness of a complex aspergilloma is defined to be more than 0.3 cm.
- An analysis of clinical efficacy of microsurgical resection of intradural neoplasm by unilateral approach with Caspar retractors. [Journal Article]Med Princ Pract 2019MP
- CONCLUSIONS: The microsurgical resection of intraspinal tumors with the aid of Caspar retractors has advantages of small trauma, less bleeding and faster recovery. It is a safe and efficacious method for treating small intraspinal tumors.
- A Prospective Study Evaluating the Clinical Utility of the Tag-Less Patency Capsule with Extended Time for Confirming Functional Patency. [Journal Article]Digestion 2019; :1-8D
- CONCLUSIONS: Extending the time to confirm functional patency to 72 h may be acceptable and increase the possibility to perform CE safely in whom CE can perform intrinsically. University Hospital Medical Information Network registration No: 000002564.
- Extremely Low Birth Weight Predisposes to Impaired Renal Health: A Pooled Analysis. [Meta-Analysis]Kidney Blood Press Res 2019; :1-10KB
- CONCLUSIONS: ELBW is associated with lower eGFR and a high frequency of preHT and HT.
- The 808 nm and 980 nm infrared laser irradiation affects spore germination and stored calcium homeostasis: A comparative study using delivery hand-pieces with standard (Gaussian) or flat-top profile. [Journal Article]J Photochem Photobiol B 2019; 199:111627JP
- Photobiomodulation relies on the transfer of energy from incident photons to a cell photoacceptor. For many years the concept of photobiomodulation and its outcome has been based upon a belief that the sole receptor within the cell was the mitochondrion. Recently, it has become apparent that there are other photoacceptors operating in different regions of the electromagnetic spectrum. Alternative…
Photobiomodulation relies on the transfer of energy from incident photons to a cell photoacceptor. For many years the concept of photobiomodulation and its outcome has been based upon a belief that the sole receptor within the cell was the mitochondrion. Recently, it has become apparent that there are other photoacceptors operating in different regions of the electromagnetic spectrum. Alternative photoacceptors would appear to be water and mechanisms regulating calcium homeostasis, despite a direct effect of laser photonic energy on intracellular calcium concentration outwith mitochondrial activity or influence, have not been clearly demonstrated. Therefore, to increase the knowledge of intracellular‑calcium and laser photon interaction, as well as to demonstrate differences in irradiation profiles with modern hand-pieces, we tested and compared the photobiomodulatory effect of 808 nm and 980 nm diode laser light by low- and higher-energy (60s, 100 mW/cm2, 100 mW/cm2, 500 mW/cm2, 1000 mW/cm2, 1500 mW/cm2, 2000 mW/cm2) irradiated with a "standard" (Gaussian fluence distribution) hand-piece or with a "flat-top" (uniform fluence) hand-piece. For this purpose, we used the eukaryote unicellular-model Dictyostelium discoideum. The 808 nm and 980 nm infrared laser light, at the energy tested directly affect the stored Ca2+ homeostasis, independent of the mitochondrial respiratory chain activities. From an organism perspective, the effect on Ca2+-dependent signal transduction as the regulator of spore germination in Dictyostelium, demonstrates how a cell can respond quickly to the correct laser photonic stimulus through a different cellular pathway than the known light-chromophore(mitochondria) interaction. Additionally, both hand-piece designs tested were able to photobiomodulate the D. discoideum cell; however, the hand-piece with a flat-top profile, through uniform fluence levels allows more effective and reproducible effects.
- Post-Ablation Cavity Evaluation (PACE): A Prospective, Multi-center, Observational Clinical Study to Evaluate Hysteroscopic Access to the Uterine Cavity Four Years After Water Vapor Endometrial Ablation for the Treatment of Heavy Menstrual Bleeding. [Journal Article]J Minim Invasive Gynecol 2019JM
- CONCLUSIONS: Water vapor endometrial ablation preserved an accessible uterine cavity and visualization of the ostia in the majority of subjects, with minimal incidence of severe adhesions a mean of four years following the ablation procedure.
- Posterior cervical muscle-preserving interspinous process approach and decompression: more minimally invasive and modified Shiraishi's selective laminectomy. [Journal Article]World Neurosurg 2019WN
- CONCLUSIONS: The MIS approach and decompression method is less invasive than both conventional laminoplasty and Shiraishi's selective laminectomy. It is a safe and effective minimally invasive technique for central stenosis caused by cervical spondylotic myelopathy.
- Collagen dressing in the treatment of diabetic foot ulcer: A prospective, randomized, placebo-controlled, single-center study. [Journal Article]Diabetes Res Clin Pract 2019; :107861DR
- CONCLUSIONS: Wound management using collagen materials in DFUs showed faster and complete healing rate.
- Percutaneous Nephrolithotomy in the 80 Years of Age and Older Population. [Journal Article]Urology 2019U
- CONCLUSIONS: PCNL is feasible in the extremely elderly; however with a higher rate of complications and longer hospitalizations. No long-term sequelae or deaths in the 80 and older cohort were seen. This study allows us to appropriately counsel older patients on a realistic postoperative course and supports use of PCNL as the best means of long term survival.
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- Reversal of Hartmann's procedure in patients following failed colorectal or coloanal anastomosis: an analysis of 45 consecutive cases. [Journal Article]Colorectal Dis 2019CD
- CONCLUSIONS: HR can be recommended in patients following a failed CRA or CAA. It permits 78% of patients to be free of stoma. A short length of the remnant rectal stump is the only predictive factor of persistent stoma in these patients.