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(cobimetinib)
235 results
  • The Medical Therapy of Craniopharyngiomas: The Way Ahead. [Journal Article]
    J Clin Endocrinol Metab 2019; 104(12):5751-5764Alexandraki KI, Kaltsas GA, … Grossman AB
  • CONCLUSIONS: The identification of specific genetic alterations in patients with craniopharyngiomas has expanded the therapeutic options, providing evidence for a customized approach using newer molecular agents. More studies including a larger number of carefully selected patients are required to evaluate the response to currently available and evolving agents alone and in combination.
  • MEK inhibitor cobimetinib rescues a dRaf mutant lethal phenotype in Drosophila melanogaster. [Journal Article]
    Exp Dermatol 2019; 28(9):1079-1082Pfeifle I, Bohnekamp J, … Kunz M
  • Since Drosophila melanogaster has proven to be a useful model system to study phenotypes of oncogenic mutations and to identify new anti-cancer drugs, we generated human BRAFV600E homologous dRaf mutant (dRafA572E) Drosophila melanogaster strains to use these for characterisation of mutant phenotypes and exploit these phenotypes for drug testing. For mutant gene expression, the GAL4/UAS expressio…
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