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(codeine)
9,209 results
  • Prevalence and Health Characteristics of Prescription Opioid Use, Misuse, and Use Disorders Among U.S. Adolescents. [Journal Article]
    J Adolesc Health 2020Carmona J, Maxwell JC, … Wu LT
  • CONCLUSIONS: In this national sample, multiple substance use was common among adolescents with past-year POU and NMPOU. Clinical screening for opioid use problems, assessment, and treatment expansion for POUD can focus on persons with substance use, mental health, and/or behavioral problems. Longitudinal studies are needed to better elucidate temporal associations between POU and NMPOU/POUD among adolescents, and more prevention and treatment research on rural residents and minority groups is needed.
  • Opioid prescriptions in patients with osteoarthritis: a population-based cohort study. [Journal Article]
    Rheumatology (Oxford) 2020van den Driest JJ, Schiphof D, … Bierma-Zeinstra SMA
  • CONCLUSIONS: Prescription rates for opioids remained stable, but types of opioids prescribed changed. Oxycodone and fentanyl were increasingly prescribed, while prescriptions of paracetamol/codeine decreased. Since the benefit of opioids for OA pain is questionable and side effects are common, opioids should be prescribed with caution.
  • Efficient DNA Condensation by a C3 -Symmetric Codeine Scaffold. [Journal Article]
    Chempluschem 2019; 84(1):38-42McStay N, Reilly AM, … Kellett A
  • A novel tripodal codeine scaffold (CC3) was rationally designed using computational methods as a DNA condensing alkaloid. Separation of the piperidine nitrogen atoms in CC3 is considerably larger at 14.36 Å than previously reported tripodal opioids allowing for enhanced aggregation of larger DNA plasmids (>4,000 bp). The scaffold undergoes protonation at physiological pH that allows for controlle…
  • Stereodivergent routes in organic synthesis: carbohydrates, amino acids, alkaloids and terpenes. [Review]
    Org Biomol Chem 2020Nájera C, Foubelo F, … Yus M
  • The natural occurrence of enantiomers and diastereomers is often encountered. In addition, the synthesis of these stereoisomers is important for structure determination and for the study of structure-activity relationships. Stereodivergent routes simplify the access to these molecules starting from a common material. This review is focused on the synthesis of carbohydrates, amino acids, alkaloids…
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