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9,111 results
  • Prescription opioid dispensing in Australian children and adolescents: a national population-based study. [Journal Article]
    Lancet Child Adolesc Health 2019Bell J, Paget SP, … Nassar N
  • CONCLUSIONS: In 2017, one in 74 Australian children, including one in 25 adolescents, were dispensed an opioid. Dispensing of weak opioids decreased between 2013 and 2017, but codeine is still commonly dispensed in younger children and education to reduce this practice is required. Dispensing of strong opioids increased in all age groups. Children and adolescents must receive appropriate pain management, but further evidence on the risks and benefits of opioid use in this young population is needed.
  • Postmortem Fluid Concentrations of Heroin Biomarkers and Their Metabolites. [Journal Article]
    J Forensic Sci 2019Al-Asmari AI
  • Only limited data exist concerning the utility of complementary specimens in heroin-related deaths. As such, this report employed a validated LC-MS-MS method to quantify 6-monoacetylmorphine (6-MAM), 6-acetylcodeine (6-AC), and their metabolites morphine and codeine in blood with (BN) and without preservative (B) and the additional unpreserved specimens of vitreous humor, urine, stomach contents,…
  • An Opioid Prescription for Men Undergoing Minor Urologic Surgery Is Associated with an Increased Risk of New Persistent Opioid Use. [Journal Article]
    Eur Urol 2019Welk B, McClure JA, … Campbell J
  • CONCLUSIONS: We identified 91 083 men, most of whom underwent vasectomy (78%). A total of 32 174 (35%) men filled a prescription for an opioid after their procedure. The most common opioid prescribed was codeine (70%), and urologists were the primary prescribers (81%). Men who filled a postprocedure opioid prescription did not differ, for most of the 57 medical comorbidities or markers of healthcare utilization that we measured, from those who did not fill an opioid prescription. There was long-term opioid use in 1447 (1.6%); men who had filled a postoperative opioid prescription had a significantly higher risk of long-term opioid use (odds ratio [OR] 1.4, 95% confidence interval [CI] 1.3-1.6) and opioid overdose (OR 3.0, 95% CI 1.5-5.9). A limitation is that we could not determine the indication for long-term opioid prescriptions.Prescription of opioids after low acuity urology procedures is significantly associated with increased opioid use at 1yr after surgery; efforts should be made to reduce postoperative opioids, especially for urologic procedures that do not typically require opioids.
  • Trends of Opioid Utilisation in Denmark: A Nationwide Study. [Journal Article]
    Drugs Real World Outcomes 2019Nissen SK, Pottegård A, Ryg J
  • CONCLUSIONS: Tramadol is the most utilised opioid in Denmark and was prescribed at increasing doses or strengths over the study period, particularly in the younger (< 80 years) age groups. Overall, oxycodone was prescribed at decreasing doses or strengths over time but remained unchanged for the age group ≥ 80 years. There is a need to address the pharmacological treatment of pain in terms of age, with tramadol and oxycodone being possible targets for regulatory efforts.
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