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291 results
  • Preclinical discovery and development of colesevelam for the treatment of type 2 diabetes. [Journal Article]
    Expert Opin Drug Discov 2018; 13(12):1161-1167Nerild HH, Christensen MB, … Brønden A
  • Introduction: Type 2 diabetes (T2D) is a major global health challenge associated with increased cardiovascular morbidity and mortality. Intervention strategies managing multiple risk factors (hyperglycemia, hypertension and dyslipidemia) in patients with T2D can reduce the risk of cardiovascular disease by ~50%. Areas covered: Herein, the authors provide an update on the development and clinical…
  • Familial Hypercholesterolaemia Diagnosis and Management. [Review]
    Eur Cardiol 2018; 13(1):14-20Alonso R, Perez de Isla L, … Mata P
  • Familial hypercholesterolaemia is the most common monogenic disorder associated with premature coronary artery disease. Mutations are most frequently found in the LDL receptor gene. Clinical criteria can be used to make the diagnosis; however, genetic testing will confirm the disorder and is very useful for cascade screening. Early identification and adequate treatment can improve prognosis, redu…
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