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90,783 results
  • Translational Genomics and Recent Advances in Oral Squamous Cell Carcinoma. [Review]
    Semin Cancer Biol 2019Yeeng Chai AW, Lim KP, Cheong SC
  • Oral squamous cell carcinomas (OSCC) are a heterogeneous group of cancers arising from the mucosal lining of the oral cavity. A majority of these cancers are associated with lifestyle risk habits including smoking, excessive alcohol consumption and betel quid chewing. Cetuximab, targeting the epidermal growth factor receptor was approved for the treatment of OSCC in 2006, and remains the only mol…
  • Molecular targeted therapy of glioblastoma. [Review]
    Cancer Treat Rev 2019; 80:101896Le Rhun E, Preusser M, … Weller M
  • Glioblastomas are intrinsic brain tumors thought to originate from neuroglial stem or progenitor cells. More than 90% of glioblastomas are isocitrate dehydrogenase (IDH)-wildtype tumors. Incidence increases with age, males are more often affected. Beyond rare instances of genetic predisposition and irradiation exposure, there are no known glioblastoma risk factors. Surgery as safely feasible foll…
  • Helminth-microbiota cross-talk - a journey through the vertebrate digestive system. [Review]
    Mol Biochem Parasitol 2019; :111222Cortés A, Peachey L, … Cantacessi C
  • The gastrointestinal (GI) tract of vertebrates is inhabited by a vast array of organisms, that is, the microbiota and macrobiota. The former is composed largely of commensal microorganisms, which play vital roles in host nutrition and maintenance of energy balance, in addition to supporting the development and function of the vertebrate immune system. By contrast, the macrobiota includes parasiti…
  • Nuclear receptor Nr4a1 regulates striatal striosome development and dopamine D1 receptor signaling. [Journal Article]
    eNeuro 2019Cirnaru MD, Melis C, … Ehrlich ME
  • The GABAergic medium-size spiny neuron (MSN), the striatal output neuron, may be classified into striosome, also known as patch, and matrix, based on neurochemical differences between the two compartments. Up to date, little is known regarding the regulation of development of the two compartments. Nr4a1, primarily described as a nuclear receptor/immediate early gene involved in the homeostasis of…
  • Inhibitory learning of phototaxis by honeybees in a passive-avoidance task. [Journal Article]
    Learn Mem 2019; 26(10):412-423Marchal P, Villar ME, … Giurfa M
  • Honeybees are a standard model for the study of appetitive learning and memory. Yet, fewer attempts have been performed to characterize aversive learning and memory in this insect and uncover its molecular underpinnings. Here, we took advantage of the positive phototactic behavior of bees kept away from the hive in a dark environment and established a passive-avoidance task in which they had to s…
  • Arthroscopic debridement for osteoarthritis of the elbow: Results and analysis of predictive factors. [Journal Article]
    Orthop Traumatol Surg Res 2019Carlier Y, Lenoir H, … French Arthroscopy Society (SFA)
  • CONCLUSIONS: Arthroscopic treatment of osteoarthritis of the elbow significantly improved clinical results at 6 months, with significant improvements in functional scores, pain, strength and range of motion. Gender, type of work and work-accident/occupational disease status influenced clinical results. Lateral ramp release is an often overlooked technical factor improving functional results. Radiologically, the best candidates are those presenting with a foreign body and no humeroulnar impingement.
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