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(compartmental modeling)
1,430 results
  • Within-Host Viral Dynamics in a Multi-compartmental Environment. [Journal Article]
    Bull Math Biol 2019Chen SS, Cheng CY, Rong L
  • The discrepancy in the turnover of cells and virus in different organs or viral reservoirs necessitates the investigation of multiple compartments within a host. Establishing a multi-compartmental structure that describes the complexity of various organs, where viral infection comprehensively proceeds, provides a modeling framework for exploring the effect of spatial heterogeneity on viral dynami…
  • Evaluation of pharmacokinetic modeling strategies for in-vivo quantification of tau with the radiotracer [18F]MK6240 in human subjects. [Journal Article]
    Eur J Nucl Med Mol Imaging 2019; 46(10):2099-2111Guehl NJ, Wooten DW, … Normandin MD
  • CONCLUSIONS: [18F]MK6240 exhibited a wide dynamic range of uptake, with binding patterns in MCI/AD subjects consistent with neurofibrillary tau deposition patterns. Linearized reference tissue methods using an estimated average tissue-to-plasma efflux constant [Formula: see text] and static SUVR agreed well with blood-based methods for most data sets; however, discrepancies were noted in the highest binding cases. Caution should therefore be exercised in application of simplified methods to such data sets, and in quantitative interpretation of corresponding outcomes.
  • Physiologically based ocular pharmacokinetic modeling using computational methods. [Review]
    Drug Discov Today 2019Missel PJ, Sarangapani R
  • By explicitly representing ocular anatomy, computational fluid dynamic simulation methods model drug mass transport both within and between ocular tissue regions, providing reliable animal-to-human translation of bioavailability. Here, we apply physiologically based models to simulate ocular drug administration. A non-anatomical model is used that applies a simple theorem for calculating ocular b…
  • Validation and noninvasive kinetic modeling of [11C]UCB-J PET imaging in mice. [Journal Article]
    J Cereb Blood Flow Metab 2019; :271678X19864081Bertoglio D, Verhaeghe J, … Staelens S
  • Synaptic pathology is associated with several brain disorders, thus positron emission tomography (PET) imaging of synaptic vesicle glycoprotein 2A (SV2A) using the radioligand [11C]UCB-J may provide a tool to measure synaptic alterations. Given the pivotal role of mouse models in understanding neuropsychiatric and neurodegenerative disorders, this study aims to validate and characterize [11C]UCB-…
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