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1,379,749 results
  • Paired Kidney Exchange Transplantation - Pushing the boundaries. [Review]
    Transpl Int. 2020 Jul 07 [Online ahead of print]Kher V, Jha PK
  • The scarcity of living organ donors makes it imperative to develop newer innovations to optimize and maximize the utilization of the available pool. ABO and HLA sensitization are important immunological barriers in renal transplant and can potentially lead to rejection of almost one-third of the willing living donors. Paired kidney exchange (PKE) is a rapidly growing method used to overcome these…
  • [Posterior cortical atrophy-plus syndrome. A case report]. [Journal Article]
    Fortschr Neurol Psychiatr. 2020 Jul 07 [Online ahead of print]Saleh C, Seidl U, … Fehrenbach RA
  • Posterior cortical atrophy (PCA) is a rare neurodegenerative disease, which manifests with complex visual disturbances. PCA can present in isolation ('PCA-pure') or in association with other neurodegenerative disorders ('PCA-plus'). Diagnosis is nevertheless frequently delayed, as PCA is a less known disease entity and initially a primary ocular disease is taken into consideration.
  • Head and Neck Cancers, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology. [Journal Article]
    J Natl Compr Canc Netw. 2020 Jul; 18(7):873-898.Pfister DG, Spencer S, … Darlow SD
  • Treatment is complex for patients with head and neck (H&N) cancers with specific site of disease, stage, and pathologic findings guiding treatment decision-making. Treatment planning for H&N cancers involves a multidisciplinary team of experts. This article describes supportive care recommendations in the NCCN Guidelines for Head and Neck Cancers, as well as the rationale supporting a new section…
  • Dissecting genetic determinants of variation in human immune responses. [Review]
    Curr Opin Immunol. 2020 Jul 04; 65:74-78.Tong O, Fairfax BP
  • The immune system is paradigmatic for a complex arrangement of heterogenous cells performing distinct, frequently temporally and anatomically dissociated, functions. Immune dysfunction is a common characteristic across most diseases and human genetic approaches have revealed that many disease risk loci are associated with expression profiles and counts of specific immune subsets. Furthermore, gen…
  • Recent advances in single-molecule fluorescence microscopy render structural biology dynamic. [Review]
    Curr Opin Struct Biol. 2020 Jul 04; 65:61-68.Bacic L, Sabantsev A, Deindl S
  • Single-molecule fluorescence microscopy has long been appreciated as a powerful tool to study the structural dynamics that enable biological function of macromolecules. Recent years have witnessed the development of more complex single-molecule fluorescence techniques as well as powerful combinations with structural approaches to obtain mechanistic insights into the workings of various molecular …
  • Optimal linker length for small molecule PROTACs that selectively target p38α and p38β for degradation. [Journal Article]
    Eur J Med Chem. 2020 Jun 18; 201:112451.Donoghue C, Cubillos-Rojas M, … Nebreda AR
  • We report the design of hetero-bifunctional small molecules that selectively target p38α and p38β for degradation. These proteolysis targeted chimeras (PROTACs) are based on an ATP competitive inhibitor of p38α and p38β, which is linked to thalidomide analogues to recruit the Cereblon E3 ubiquitin ligase complex. Compound synthesis was facilitated by the use of a copper catalyzed "click" reaction…
  • Functional genomics links genetic origins to pathophysiology in neurodegenerative and neuropsychiatric disease. [Review]
    Curr Opin Genet Dev. 2020 Jul 04; 65:117-125.Wamsley B, Geschwind DH
  • Neurodegenerative and neuropsychiatric disorders are pervasive and debilitating conditions characterized by diverse clinical syndromes and comorbidities, whose origins are as complex and heterogeneous as their associated phenotypes. Risk for these disorders involves substantial genetic liability, which has fueled large-scale genetic studies that have led to a flood of discoveries. In turn, these …
  • NLRC3-like 1 inhibits NOD1-RIPK2 pathway via targeting RIPK2. [Journal Article]
    Dev Comp Immunol. 2020 Jul 04 [Online ahead of print]Fang H, Wu XM, … Chang MX
  • Both NLRC3 and NOD1 belong to regulatory NLR subfamily based on their best-characterized function. In mammals, NLRC3 was reported to function by attenuating signaling cascades initiated by other families of PRRs. In teleosts, multiple NLRC3-like genes were identified through transcriptome sequencing. However, the functions of many NLRC3-like genes, especially the fish-specific NLRC3-like genes, r…
  • Low bone mineral density in adults with complex congenital heart disease. [Journal Article]
    Int J Cardiol. 2020 Jul 04 [Online ahead of print]Sandberg C, Johansson K, … Johansson B
  • CONCLUSIONS: Adults with complex CHD have reduced total body BMC and BMD compared to healthy controls. These results are a sign of frailty that conforms with other previously reported signs of premature ageing. The risk of osteoporosis is low in our relatively young population, but it is assumed to increase with ageing. We recommend that clinicians pay close attention to risk factors for osteoporosis, and are generous in administering DXA-measurements in order to prevent future fractures among adults with complex CHD.
  • Autophagy in the crosstalk between tumor and microenvironment. [Journal Article]
    Cancer Lett. 2020 Jul 04 [Online ahead of print]Camuzard O, Santucci-Darmanin S, … Pierrefite-Carle V
  • Autophagy is the major catabolic process in eukaryotic cells for the degradation and recycling of damaged macromolecules and organelles. It plays a crucial role in cell quality control and nutrient supply under stress conditions. Although autophagy is classically described as a degradative mechanism, it can also be involved in some secretion pathways, leading to the extracellular release of prote…
  • The nuclear envelope: LINCing tissue mechanics to genome regulation in cardiac and skeletal muscle. [Journal Article]
    Biol Lett. 2020 Jul; 16(7):20200302.Piccus R, Brayson D
  • Regulation of the genome is viewed through the prism of gene expression, DNA replication and DNA repair as controlled through transcription, chromatin compartmentalisation and recruitment of repair factors by enzymes such as DNA polymerases, ligases, acetylases, methylases and cyclin-dependent kinases. However, recent advances in the field of muscle cell physiology have also shown a compelling ro…
  • Avian major histocompatibility complex copy number variation is associated with helminth richness. [Journal Article]
    Biol Lett. 2020 Jul; 16(7):20200194.Minias P, Gutiérrez JS, Dunn PO
  • Genes of the major histocompatibility complex (MHC) play a key role in the adaptive immunity of vertebrates, as they encode receptors responsible for antigen recognition. Evolutionary history of the MHC proceeded through numerous gene duplications, which increase the spectrum of pathogens recognized by individuals. Although pathogen-mediated selection is believed to be a primary driver of MHC exp…
  • EMS Access Constraints And Response Time Delays For Deprived Critically Ill Patients Near Paris, France. [Journal Article]
    Health Aff (Millwood). 2020 Jul; 39(7):1175-1184.Heidet M, Da Cunha T, … Audureau E
  • Increased emergency medical services (EMS) response times and areas of low socioeconomic status are both associated with poorer outcomes for several time-sensitive medical conditions attended to by medical personnel before a patient is hospitalized. We evaluated the association between EMS response times, area deprivation level, and on-scene access constraints encountered by EMS in a large urban …
  • Nutritional Aspects of Spermidine. [Journal Article]
    Annu Rev Nutr. 2020 Jul 07 [Online ahead of print]Madeo F, Hofer SJ, … Kroemer G
  • Natural polyamines (spermidine and spermine) are small, positively charged molecules that are ubiquitously found within organisms and cells. They exert numerous (intra)cellular functions and have been implicated to protect against several age-related diseases. Although polyamine levels decline in a complex age-dependent, tissue-, and cell type-specific manner, they are maintained in healthy nonag…
  • Approval of Biosimilars: A Review of Unsuccessful Regulatory Filings. [Journal Article]
    Expert Opin Biol Ther. 2020 Jul 07 [Online ahead of print]Rathore AS, Chhabra H, Bhargava A
  • Over the past three decades, biotherapeutics have transformed healthcare by offering effective treatments for complex diseases which were otherwise difficult to deal with via small molecule pharmaceuticals. Patents on several biotherapeutics have expired or are due to expire in recent times, and this has fuelled growth in biosimilars, products that are deemed to be similar to the already approved…
  • Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria. [Journal Article]
    J Med Chem. 2020 Jul 07 [Online ahead of print]Skepper CK, Armstrong D, … Rivkin A
  • Since their discovery over 5 decades ago, quinolone antibiotics have found enormous success as broad spectrum agents that exert their activity through dual inhibition of bacterial DNA gyrase and topoisomerase IV. Increasing rates of resistance, driven largely by target-based mutations in the GyrA/ParC quinolone resistance determining region, have eroded the utility and threaten the future use of …
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