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335,352 results
  • A divergent mode of activation of a nitrosyl iron complex with unusual antiangiogenic activity. [Journal Article]
    J Inorg Biochem. 2020 Jun 20; 210:111133.Carvalho EM, Ridnour LA, … Lopes LGF
  • Nitric oxide (NO) and nitroxyl (HNO) have gained broad attention due to their roles in several physiological and pathophysiological processes. Remarkably, these sibling species can exhibit opposing effects including the promotion of angiogenic activity by NO compared to HNO, which blocks neovascularization. While many NO donors have been developed over the years, interest in HNO has led to the re…
  • Drug repurposing: Discovery of troxipide analogs as potent antitumor agents. [Journal Article]
    Eur J Med Chem. 2020 Jun 26; 202:112471.Lu N, Huo JL, … Liu HM
  • Drug repurposing plays a vital role in the discovery of undescribed bioactivities in clinical drugs. Based on drug repurposing strategy, we for the first time reported a novel series of troxipide analogs and then evaluated their antiproliferative activity against MCF-7, PC3, MGC-803, and PC9 cancer cell lines and WPMY-1, most of which showed obvious selectivity toward PC-3 over the other three ca…
  • Biosynthesis and tissue-specific partitioning of camphor and eugenol in Ocimum kilimandscharicum. [Journal Article]
    Phytochemistry. 2020 Jun 30; 177:112451.Singh P, Kalunke RM, … Giri AP
  • In Ocimum kilimandscharicum, the relative volatile composition of camphor in leaves was as high as 55%, while that of eugenol in roots was 57%. These metabolites were differentially partitioned between the aerial and root tissues. Global metabolomics revealed tissue-specific biochemical specialization, evident by the differential distribution of 2588 putative metabolites across nine tissues. Next…
  • (-)-Kusunokinin inhibits breast cancer in N-nitrosomethylurea-induced mammary tumor rats. [Journal Article]
    Eur J Pharmacol. 2020 Jun 30 [Online ahead of print]Tedasen A, Dokduang S, … Graidist P
  • Natural and synthetic (-)-kusunokinin inhibited breast cancer, colon cancer and cholangiocarcinoma cells at the G2/M phase and induced apoptosis. However, there is no report on the action and adverse effects of (-)-kusunokinin in animal models. In this study, we investigated the cytotoxic effect of (-)-kusunokinin from Piper nigrum on cancer cells. NMU-induced rat mammary tumors, an ER positive b…
  • [Analysis of TWNK variant in a family affected with Perrault syndrome]. [Journal Article]
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2020 Jul 10; 37(7):739-742.Chen Z, Tang S, … Lyu J
  • CONCLUSIONS: The compound heterozygous variants c.1172G>A (p.Arg391His) and c.1844G>C (p.Gly615Ala) of the TWNK gene probably underlie PRLTS in the sib pair. The above results have facilitated genetic counseling and prenatal diagnosis for the affected family.
  • [Clinical characteristics and variant analysis of five pedigrees with hereditary spastic paraplegia]. [Journal Article]
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2020 Jul 10; 37(7):709-712.Xie Y, Xia Y, … Kong X
  • CONCLUSIONS: The probands of pedigrees 1 and 2 were diagnosed with autosomal dominant hereditary spastic paraplegia type 4, for which pedigree 2 showed incompletely penetrance. Pedigrees 3, 4, and 5 were diagnosed with autosomal recessive hereditary spastic paraplegia type 35, 11 and 7, respectively. Above result provided a reference for clinical diagnosis and genetic counseling for the affected pedigrees.
  • Selective autophagy inhibition through disruption of the PIK3C3-containing complex I. [Journal Article]
    Autophagy. 2020 Jul 03 [Online ahead of print]Pavlinov I, Salkovski M, Aldrich LN
  • The PIK3C3/VPS34-containing phosphatidylinositol 3-kinase (PtdIns3K) initiation complex (complex I) is necessary for macroautophagy/autophagy initiation and is comprised of PIK3R4/VPS15-PIK3C3/VPS34-BECN1-ATG14, while the endosomal trafficking complex (complex II) is necessary for vesicle trafficking and is comprised of PIK3R4/VPS15-PIK3C3/VPS34-BECN1-UVRAG. This composition difference was exploi…
  • Allicin-induced host-gut microbe interactions improves energy homeostasis. [Journal Article]
    FASEB J. 2020 Jul 03 [Online ahead of print]Zhang C, He X, … Huang K
  • Allicin (diallylthiosulfinate) is a natural food compound with multiple biological and pharmacological functions. However, the mechanism of beneficial role of Allicin on energy homeostasis is not well studied. Gut microbiota (GM) profoundly affects host metabolism via microbiota-host interactions and coevolution. Here, we investigated the interventions of beneficial microbiome induced by Allicin …
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