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(computational knowledge)
13,791 results
  • Transition Scale-Spaces: A Computational Theory for the Discretized Entorhinal Cortex. [Journal Article]
    Neural Comput 2019; :1-65Waniek N
  • Although hippocampal grid cells are thought to be crucial for spatial navigation, their computational purpose remains disputed. Recently, they were proposed to represent spatial transitions and convey this knowledge downstream to place cells. However, a single scale of transitions is insufficient to plan long goal-directed sequences in behaviorally acceptable time. Here, a scale-space data struct…
  • Comparison Study of Computational Prediction Tools for Drug-Target Binding Affinities. [Review]
    Front Chem 2019; 7:782Thafar M, Raies AB, … Bajic VB
  • The drug development is generally arduous, costly, and success rates are low. Thus, the identification of drug-target interactions (DTIs) has become a crucial step in early stages of drug discovery. Consequently, developing computational approaches capable of identifying potential DTIs with minimum error rate are increasingly being pursued. These computational approaches aim to narrow down the se…
  • Analysis of Secondary Structure Biases in Naturally Presented HLA-I Ligands. [Journal Article]
    Front Immunol 2019; 10:2731Perez MAS, Bassani-Sternberg M, … Zoete V
  • Recent clinical developments in antitumor immunotherapy involving T-cell related therapeutics have led to a renewed interest for human leukocyte antigen class I (HLA-I) binding peptides, given their potential use as peptide vaccines. Databases of HLA-I binding peptides hold therefore information on therapeutic targets essential for understanding immunity. In this work, we use in depth and accurat…
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