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250,957 results
  • Neural and muscular determinants of maximal rate of force development. [Journal Article]
    J Neurophysiol 2019Dideriksen JL, Del Vecchio A, Farina D
  • The ability to produce rapid forces requires quick motor unit recruitment, high motor unit discharge rates, and fast motor unit force twitches. The relative importance of these parameters for maximum rate of force development (RFD), however, is poorly understood. In this study, we systematically investigated these relations using a computational model of motor unit pool activity and force. Across…
  • Trimebutine: a state-of-the-art review. [Journal Article]
    Minerva Gastroenterol Dietol 2019; 65(3):229-238Salvioli B
  • Trimebutine maleate has been used extensively, since the late 1960's, for the treatment of functional gastrointestinal disorders, including irritable bowel syndrome (IBS). It is usually linked to the antispasmodic class of agents, but its properties make trimebutine an unmatched and multi-tasking compound. The efficacy on relieving abdominal pain has been demonstrated in various clinical studies …
  • Quantitative nuclear magnetic resonance imaging detects subclinical changes over 1 year in skeletal muscle of GNE myopathy. [Journal Article]
    J Neurol 2019Gidaro T, Reyngoudt H, … Servais L
  • CONCLUSIONS: Even in a limited number of patients, qNMRI could detect a significant change over a 1-year period in GNE myopathy, which suggests that qNMRI could constitute a surrogate endpoint in this slowly progressive disease. Quantitative NMRI outcome measures can monitor intramuscular fat accumulation with high responsiveness. Longer follow-up should improve our understanding of GNE myopathy evolution and also lead to the identification of non-invasive outcome measures with the highest discriminant power for upcoming clinical trials.
  • Cellular defects resulting from disease-related myosin II mutations in Drosophila. [Journal Article]
    Proc Natl Acad Sci U S A 2019Kasza KE, Supriyatno S, Zallen JA
  • The nonmuscle myosin II motor protein produces forces that are essential to driving the cell movements and cell shape changes that generate tissue structure. Mutations in myosin II that are associated with human diseases are predicted to disrupt critical aspects of myosin function, but the mechanisms that translate altered myosin activity into specific changes in tissue organization and physiolog…
  • Extracellular Matrix in Regulation of Contractile System in Cardiomyocytes. [Review]
    Int J Mol Sci 2019; 20(20)Bildyug N
  • The contractile apparatus of cardiomyocytes is considered to be a stable system. However, it undergoes strong rearrangements during heart development as cells progress from their non-muscle precursors. Long-term culturing of mature cardiomyocytes is also accompanied by the reorganization of their contractile apparatus with the conversion of typical myofibrils into structures of non-muscle type. P…
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