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229,847 results
  • Electric Phenomenon: A Disregarded Tool in Tissue Engineering and Regenerative Medicine. [Review]
    Trends Biotechnol 2019da Silva LP, Kundu SC, … Correlo VM
  • Tissue engineering and regenerative medicine (TERM) are paving the way to the generation of functional and mature biological tissues that closely emulate cellular, biochemical, and mechanical cues. Electrical fields in the human body modulate myriad biological processes, such as synapses, muscle contraction, hearing, and wound healing, which were disregarded in TERM until recently. To preserve an…
  • trans-δ-Viniferin inhibits Ca2+-activated Cl- channels and improves diarrhea symptoms. [Journal Article]
    Fitoterapia 2019; :104367Yu B, Xie R, … Yang H
  • Ca2+-activated Cl- channels (CaCCs) wildly exist in many tissues which play an important role in ion transport and excitation conduction, especially fluid secretion and smooth muscle contraction in epithelial tissues. TMEM16A as a classic CaCC expresses in the intestine, and has become a potential target of intestinal physiological and pathological researches and therapeutic drug screening. In th…
  • Sorocea guilleminiana Gaudich.: Wound healing activity, action mechanisms, and chemical characterization of the leaf infusion. [Journal Article]
    J Ethnopharmacol 2019; :112307de Freitas Figueiredo F, Filho VC, … Tabajara de Oliveira Martins D
  • CONCLUSIONS: AESg is not cytotoxic. The results confirm the popular use of the leaf infusion of S. guilleminiana for the treatment of cutaneous wounds, possibly by stimulating the proliferation of fibroblasts with a consequent deposition of collagen, fastening rearrangement of collagen fibers, and greater transformation into myofibroblasts, essential in the healing process. Preliminary chemical analyzes of AESg revealed the presence mainly of phenolic compounds, being salicylic acid, gallic acid, pinocembrin and isoquercitrin the majoritarian ones.
  • RabGAPs TBC1D1 and TBC1D4 in skeletal muscle function and exercise. [Review]
    J Mol Endocrinol 2019Espelage L, Al-Hasani H, Chadt A
  • The two closely related RabGAPs TBC1D1 and TBC1D4 are key signaling factors of skeletal muscle substrate utilization. In mice, deficiency in both RabGAPs leads to reduced skeletal muscle glucose transport in response to insulin and lower GLUT4 abundance. Conversely, Tbc1d1- and Tbc1d4-deficiency results in enhanced lipid use as fuel in skeletal muscle, through yet unknown mechanisms. In humans, v…
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