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5,997 results
  • Genetic bases of craniosynostoses: An update. [Review]
    Neurochirurgie 2019; 65(5):196-201Armand T, Schaefer E, … Rossi M
  • Craniosynostosis (CS) is defined as the premature fusion of cranial sutures, leading to an abnormal skull shape. The overall incidence is between 1: 2,000 and 1: 3,000 live births. Genetic causes are found in 20% of cases. CS can be isolated (non-syndromic CS/NSCS) or they can be part of multiple congenital abnormalities syndromes (syndromic CS/SCS). A few SCS, such as Crouzon, Pfeiffer, Apert an…
  • Virtual 3D planning of osteotomies for craniosynostoses and complex craniofacial malformations. [Journal Article]
    Neurochirurgie 2019; 65(5):269-278Laure B, Louisy A, … Pare A
  • CONCLUSIONS: Computer-assisted surgery is revolutionizing the surgical approach to complex craniofacial malformations, as well as easing management of less complex ones. It is likely that in the years to come this technique will supersede previous ones. However, using this technique implies being willing to rely on a non-human device. We need to consider computer-assisted surgery as a tool that can change surgical practices. The surgeon can rely on it, yet nothing will replace his/her eye and experience. It is the combination of both this experience and the appropriate use of computer-assisted surgery that, ultimately, leads to successful surgery.
  • Animal models of craniosynostosis. [Journal Article]
    Neurochirurgie 2019; 65(5):202-209Cornille M, Dambroise E, … Legeai-Mallet L
  • CONCLUSIONS: Several zebrafish and mouse models have been developed in recent decades. These animal models have been helpful for our understanding of normal and pathological craniofacial growth. Mouse models mimicking craniosynostoses can be easily used for the screening of drugs as therapeutic candidates.
  • Sagittal suture craniosynostosis or craniosynostoses? The heterogeneity of the most common premature fusion of the cranial sutures. [Journal Article]
    Neurochirurgie 2019; 65(5):232-238Di Rocco F, Gleizal A, … Mottolese C
  • CONCLUSIONS: The complexity and heterogeneous nature of sagittal synostoses depend on different pathogenic mechanisms leading to and interfering with the skull abnormalities: abnormalities of CSF dynamics, possibly associated with systemic alterations, accounting for the varied postoperative morphological and functional course, in terms of cognitive impairment and late complications (notably intra-cranial pressure elevation). However, the real impact of such heterogeneous clinical presentations on surgical indications and surgical results remains to be elucidated.
  • [Secondary surgeries in craniosynostosis and faciocraniosynostosis]. [Journal Article]
    Ann Chir Plast Esthet 2019; 64(5-6):494-505Arnaud E, Haber SE, … Meyer PH
  • Secondary surgeries for single craniosynostosis surgeries are mainly esthetic refinements rather than functional indications. However, cranioplasties for bone defects correction or insufficient corrections may be undertaken. Management of syndromic craniosynostoses usually requires multiple surgical interventions, the sequence of which might vary per the genetic mutation. It is commonplace to sta…
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