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228,162 results
  • Chronic toxicity of methamphetamine: Oxidative remodeling of pulmonary arteries. [Journal Article]
    Toxicol In Vitro 2019; :104668Liang LY, Wang MM, … Wang Y
  • Methamphetamine (MA) has a high uptake in lung, but the precise mechanism of MA-induced lung toxicity remains unclear. The aim of this study is to investigate the role of MA abuse in remodeling of pulmonary arteries and to explore the possible correlation of the association of the remodeling with the redox imbalance in pulmonary arterial smooth muscle cells (PASMCs). Wistar rats were randomly div…
  • Carboxylic acid reductases in metabolic engineering. [Journal Article]
    J Biotechnol 2019Butler N, Kunjapur AM
  • Carboxylic acid reductases (CARs) catalyze the conversion of carboxylic acids to aldehydes, which are a valuable class of chemicals for many consumer and industrial applications. CARs generally exhibit broad substrate specificity that encompasses aromatic, aliphatic, and di/tri-carboxylic acids, enabling the development of biosynthetic pathways to a wide array of potential aldehyde products. De n…
  • Structural Insights into the Interleukin-17 Family Cytokines and Their Receptors. [Journal Article]
    Adv Exp Med Biol 2019; 1172:97-117Liu S
  • The IL-17 family in humans consists of six distinct cytokines (IL-17A-F) that can interact with five IL-17 receptors (IL-17RA-E). The interaction between these cytokines and their receptors are critical in mediating host defenses while also making major contributions to inflammatory and autoimmune responses as demonstrated through both in vitro and in vivo experiments as well as human clinical tr…
  • Concatenation of 14-3-3 with partner phosphoproteins as a tool to study their interaction. [Journal Article]
    Sci Rep 2019; 9(1):15007Tugaeva KV, Kalacheva DI, … Sluchanko NN
  • Regulatory 14-3-3 proteins interact with a plethora of phosphorylated partner proteins, however 14-3-3 complexes feature intrinsically disordered regions and often a transient type of interactions making structural studies difficult. Here we engineer and examine a chimera of human 14-3-3 tethered to a nearly complete partner HSPB6 which is phosphorylated by protein kinase A (PKA). HSPB6 includes …
  • Schools of skyrmions with electrically tunable elastic interactions. [Journal Article]
    Nat Commun 2019; 10(1):4744Sohn HRO, Liu CD, Smalyukh II
  • Coexistence of order and fluidity in soft matter often mimics that in biology, allowing for complex dynamics and applications-like displays. In active soft matter, emergent order can arise because of such dynamics. Powered by local energy conversion, this behavior resembles motions in living systems, like schooling of fish. Similar dynamics at cellular levels drive biological processes and genera…
  • Mycobacterium tuberculosisβ-Carbonic Anhydrases: Novel Targets for Developing Antituberculosis Drugs. [Review]
    Int J Mol Sci 2019; 20(20)Aspatwar A, Kairys V, … Parkkila S
  • The genome of Mycobacterium tuberculosis (Mtb) encodes three β-carbonic anhydrases (CAs, EC 4.2.1.1) that are crucial for the life cycle of the bacterium. The Mtbβ-CAs have been cloned and characterized, and the catalytic activities of the enzymes have been studied. The crystal structures of two of the enzymes have been resolved. In vitro inhibition studies have been conducted using different cla…
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