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788,377 results
  • Antitumor and anti-nematode activities of α-mangostin. [Journal Article]
    Eur J Pharmacol 2019; :172678Markowicz J, Uram Ł, … Rode W
  • α-Mangostin, one of the major xanthones isolated from pericarp of mangosteen (Garcinia mangostana Linn), exhibits a wide range of pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial as well as anticancer, both in in vitro and in vivo studies. In the present study, α-mangostin' anti-cancer and anti-parasitic properties were tested in vitro against three human cell l…
  • Liposomes augment biological benefits of curcumin for multitargeted skin therapy. [Journal Article]
    Eur J Pharm Biopharm 2019Ternullo S, Gagnat E, … Škalko-Basnet N
  • Curcumin, a multi-targeting pharmacologically active compound, is a promising molecule for the treatment of skin inflammation and infection in chronic wounds. However, its hydrophobic nature remains to be a challenge in development of its pharmaceutical products, including dermatopharmaceuticals. Here we propose deformable liposomes (DLs) as a mean to overcome the curcumin limitations in skin tre…
  • RIFM fragrance ingredient safety assessment, methyl 2-octynoate, CAS Registry Number 111-12-6. [Journal Article]
    Food Chem Toxicol 2019; :110825Api AM, Belsito D, … Tsang S
  • Methyl 2-octynoate was evaluated for genotoxicity, repeated dose toxicity, developmental and reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that methyl 2-octynoate is not genotoxic. Data provided methyl 2-octynoate a NESIL of 110 μg/cm2 for the skin sensitization endpoint. The repeated dose, developmenta…
  • In-situ immune profile of polymorphic vs. macular Indian Post Kala-azar dermal leishmaniasis. [Journal Article]
    Int J Parasitol Drugs Drug Resist 2019Sengupta R, Mukherjee S, … Chatterjee M
  • Post Kala-azar Dermal Leishmaniasis (PKDL), a sequel of apparently cured Visceral Leishmaniasis presents in South Asia with papulonodular (polymorphic) or hypomelanotic lesions (macular). Till date, the polymorphic variant was considered predominant, constituting 85-90%. However, following active-case surveillance, the proportion of macular PKDL has increased substantially to nearly 50%, necessit…
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