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173,930 results
  • Species diversity and genome evolution of the pathogenic protozoan parasite, Neospora caninum. [Review]
    Infect Genet Evol. 2020 Jun 30 [Online ahead of print]Calarco L, Ellis J
  • Neospora caninum is a cyst-forming coccidian parasite of veterinary and economical significance, affecting dairy and beef cattle industries on a global scale. Comparative studies suggest that N. caninum consists of a globally dispersed, diverse population of lineages, distinguished by their geographical origin, broad host range, and phenotypic features. This viewpoint is however changing. While i…
  • Targeting chloride transport in autosomal dominant polycystic kidney disease. [Review]
    Cell Signal. 2020 Jun 30 [Online ahead of print]Jouret F, Devuyst O
  • Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent inherited kidney disease. Transepithelial fluid secretion is one of the key factors of cystogenesis in ADPKD. Multiple studies have suggested that fluid secretion across ADPKD cyst-lining cells is driven by the secretion of chloride, essentially mediated by the CFTR channel and stimulated by increased intracellular levels o…
  • Folliculocystic and Collagen Hamartoma: A Distinct Hamartoma Associated With Tuberous Sclerosis Complex. [Journal Article]
    Am J Dermatopathol. 2020 Jun 30 [Online ahead of print]Cardona R, Cancel-Artau KJ, … Martin-Garcia RF
  • Tuberous sclerosis complex (TSC) is a neurocutaneous disease characterized by cutaneous and extracutaneous hamartomas. Dermatologic evaluation is critical for early diagnosis because mucocutaneous manifestations account for 4 of 11 major and 3 of 6 minor diagnostic criteria. Folliculocystic and collagen hamartoma (FCCH) is a recently described entity associated with TSC. We herein describe the ca…
  • Adamantinomatous craniopharyngioma: advances in proteomic research. [Journal Article]
    Childs Nerv Syst. 2020 Jul 02 [Online ahead of print]Desiderio C, Rossetti DV, … Tamburrini G
  • CONCLUSIONS: Proteins and peptides identified in the cyst fluid and in the solid component of adamantinomatous craniopharyngioma (AC) include beyond markers of inflammation (i.e., alpha-defensins), proteins involved in cell migration and protein degradation (i.e., beta-thymosin and ubiquitin peptides), whose main role might be in tumor growth and infiltration of the surrounding neural structures. These last appeared different in the solid components compared with the cyst fluid, missing their terminal part in the solid tissue, a feature generally associated to malignancies, which might represent a distinct molecular site for an aggressive behavior of AC.
  • Bronchogenic Cyst Presenting as Acute Pericarditis. [Case Reports]
    Cureus. 2020 Jun 28; 12(6):e8874.Ramireddy K, Golamari RR, … Menetrey J
  • Bronchogenic cysts are speculated to arise from abnormal budding of the foregut tissue during embryogenesis. Around 90% of mediastinal bronchogenic cysts are asymptomatic, and a small percentage of them present with chest pain and dyspnea. Pericardial effusion is one of the manifestations described; however, pericarditis has not been widely reported. We describe a case of a bronchogenic cyst in a…
  • Neurosurgical Pathology and Management of Limited Dorsal Myeloschisis Associated with Congenital Dermal Sinus in Infancy. [Case Reports]
    Pediatr Neurosurg. 2020 Jul 02 [Online ahead of print]Morioka T, Murakami N, … Iihara K
  • CONCLUSIONS: Surgeons should be aware of the approximately 10% possibility of the coexistence of CDS when managing infant LDM. However, the recommendation for excision of the entire length of the LDM stalk in all patients should be more carefully made because such a strategy may result in an unnecessary extent of laminotomy/laminectomy for most patients with pure LDM. However, once the postoperative histological examination reveals coexistence of CDS in the resected proximal part of the stalk, the entire length of the remnant stalk should be excised as soon as possible.
  • Non-Fusion Muscle-Sparing Technique to Treat Long-Segment Thoracolumbar Extradural Arachnoid Cyst in a Child: A Case Report and Review of the Literature. [Case Reports]
    World Neurosurg. 2020 Jun 29 [Online ahead of print]Santipas B, Wejjakul W, … Wilartrasmi S
  • CONCLUSIONS: Spinal arachnoid cyst is rare, especially in children. Early diagnosis and treatment are essential for improving the chance of full recovery, and for avoiding complication and irreparable defect. Total cyst removal with dural repair remains the best treatment alternative; however, potential complication, especially spinal malalignment after extensive laminectomy, must be considered. Postoperative MRI showed normal CSF flow and no spinal cord compression. The muscle-sparing technique with multiple-level laminectomy without spinal fusion that we used in this case provided a satisfying outcome.
  • Pineal Cyst Apoplexy in an 8-Year-Old Girl: Case Report and Literature Review. [Case Reports]
    World Neurosurg. 2020 Jun 29 [Online ahead of print]Goehner D, Soyland D, … Vuong S
  • CONCLUSIONS: Pineal cyst apoplexy remains a rare clinical event in the pediatric population. Our case details the diagnosis and management of an 8-year-old girl with pineal cyst apoplexy. We also discuss our findings from our literature search for all reported cases of pineal cyst apoplexy.
  • A boy with a congenital cerebellar mass. [Journal Article]
    Childs Nerv Syst. 2020 Jul 01 [Online ahead of print]Yang J, Kim SK, … Phi JH
  • CONCLUSIONS: This case provides an unusual chance of observing an early phase of medulloblastoma development and raises a suspicion that medulloblastoma may initiate itself very early in cerebellar organogenesis and progress later at a certain time of postnatal development.
  • Characteristics of primary Sjögren's syndrome related lymphocytic interstitial pneumonia. [Journal Article]
    Clin Rheumatol. 2020 Jul 01 [Online ahead of print]Dong X, Gao YL, … Zheng Y
  • CONCLUSIONS: To the patients of pSS-LIP, female were more common than male, and the onset of LIP was usually more insidious. Hyperglobulinemia and anti-SSA antibody were more prominent in patients with pSS-LIP. Pulmonary function showed the higher rate of obstructive ventilation dysfunction and the lower rate of diffusion dysfunction. The appearance of ground-glass opacities in pSS-LIP patients suggests that the infiltration of inflammatory cells increases, which may cause airway compression, the expansion of terminal bronchioles, and the formation of cysts. The more ground-glass opacities appear earlier, and the more appearance of new cysts later. Therapy with glucocorticoid may be effective on the ground-glass opacity during acute stage, and therapy with cyclophosphamide may be effective on the cysts during chronic stage. The heavier ground-glass opacity is at baseline, the more likely it will recur during maintenance treatment. So follow-up closely is needed. Key Points • It is the first clinical study with more cases of patients with pSS-LIP. • Female and hyperglobulinemia and anti-SSA antibody were more prominent in patients with pSS-LIP. • Pulmonary function showed the higher rate of obstructive ventilation dysfunction and the lower rate of diffusion dysfunction. • Therapy with glucocorticoid may be effective on the ground-glass opacity during acute stage, and therapy with cyclophosphamide may be effective on the cysts during chronic stage.
  • A rare case of squamous inclusion cyst in cervical lymph node. [Case Reports]
    Heliyon. 2020 Jun; 6(6):e04225.Houcine Y, Sassi A, … Mezni F
  • A 38-year-old man, with no history of malignancy, was found to have a 2 cm jugular lymph node, for which a lymph node tuberculosis was suspected. The specimen revealed a cystic structure lined by mature keratinizing squamous epithelium with a prominent granular cell layer consistent with a squamous inclusion cyst in a lymph node, but a metastatic squamous cell carcinoma could not be excluded. Thi…
  • Appendiceal diverticulosis in a patient with family history of Birt-Hogg-Dubé syndrome--a case report. [Case Reports]
    Radiol Case Rep. 2020 Aug; 15(8):1317-1322.Alexander A, Hunter K, … Bhat AP
  • Birt-Hogg-Dubé syndrome (BHD) is a rare autosomal dominant disorder that predisposes patients to cutaneous tumors, pulmonary cysts with recurrent spontaneous pneumothoraces, and a variety of renal neoplasms including hybrid oncocytic and chromophobe renal cell carcinomas. There has been much debate regarding the genetic link with the occurrence of colorectal cancer and other colonic anomalies. As…
  • Exploring the neglected segment of the intestine: the duodenum and its pathologies. [Review]
    Pol J Radiol. 2020; 85:e230-e244.Reghunath A, Kabilan K, Mittal MK
  • Herein we reviewed the computed tomography (CT) findings of a spectrum of pathological entities affecting the duodenum. We discuss the CT findings of some congenital, inflammatory, traumatic, and neoplastic pathologies of the duodenum along with the conventional barium studies of selected conditions. Pathologies of this C-shaped intestinal segment, derived from both foregut and midgut, are often …
  • A substrate-specific mTORC1 pathway underlies Birt-Hogg-Dubé syndrome. [Journal Article]
    Nature. 2020 Jul 01 [Online ahead of print]Napolitano G, Di Malta C, … Ballabio A
  • The mechanistic target of rapamycin complex 1 (mTORC1) is a key metabolic hub that controls the cellular response to environmental cues by exerting its kinase activity on multiple substrates1-3. However, whether mTORC1 responds to diverse stimuli by differentially phosphorylating specific substrates is poorly understood. Here we show that transcription factor EB (TFEB), a master regulator of lyso…
  • Sellar Pathologies Mimicking Pituitary Tumors. [Journal Article]
    Neurol India. 2020 May-Jun; 68(Supplement):S154-S160.Karmarkar VS, Deopujari CE
  • The most common sellar pathology that merits neurosurgical attention is the pituitary adenoma. However, some developmental, inflammatory, and neoplastic lesions may primarily or secondarily involve the sella, mimicking pituitary tumors. Advances in imaging and endocrinological assessment have helped in the recognition of these less common sellar, supra sellar pathologies, which may occasionally c…
  • EUS-through-the-needle microbiopsy forceps in pancreatic cystic lesions: A systematic review. [Review]
    Endosc Ultrasound. 2020 Jul 01 [Online ahead of print]Balaban VD, Cazacu IM, … Saftoiu A
  • Pancreatic cystic lesions (PCLs) are being increasingly encountered in clinical practice, and sometimes, they can represent a diagnostic challenge. Recently, a through-the-needle micro forceps biopsy (MFB) device was introduced in the endosonography practice to facilitate EUS-guided sampling of PCLs. The aim was to perform a systematic review of studies evaluating the technical aspects, safety, a…
  • EUS-guided through-the-needle microbiopsy of pancreatic cysts: Technical aspects (with video). [Review]
    Endosc Ultrasound. 2020 Jun 30 [Online ahead of print]Kovacevic B, Kalaitzakis E, … Vilmann P
  • Pancreatic cystic lesions are frequently encountered and diagnostically challenging as some of the cysts may have malignant potential (mucinous) while others are completely benign (serous). EUS-guided through-the-needle biopsy (EUS-TTNB) of the cyst wall has recently been introduced as an alternative to cyst fluid cytology. Several studies have shown that microbiopsies outperform cytology in term…
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