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75,816 results
  • [Influence of LBP alone or Combined with TRAIL on Apoptosis of MLL Rearranged Leukemic Cells]. [Journal Article]
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 2019; 27(4):1104-1110Chen C, Ma Y, … Zhang XC
  • CONCLUSIONS: The combination of LBP and TRAIL significantly increases the apoptosis of KOCL44 and KOCL45, and the LBP and TRAIL can up-regulate the expression of TRAIL death receptor-DR5 on the cell surface, activate the pathway of caspase and mito-chrondia mitachondria, thus enhance the sensitivity of KOCL44 and KOCL45 to TRAIL induced apoptosis through both mitochondrial and apoptotic pathway.
  • Redox-Sensitive Gelatin/Silica-Aptamer Nanogels for Targeted siRNA Delivery. [Journal Article]
    Nanoscale Res Lett 2019; 14(1):273Zhao X, Xi Y, … Rei L
  • RNA interference (RNAi) has potential advantages over other gene therapy approaches due to its high specificity and the ability to inhibit target gene expression. However, the stability and tissue-specific delivery of siRNA remain as the biggest obstacles for RNAi therapeutics. Here, we developed such a system by conjugating gelatin-based nanogels with the nucleolin-targeted AS1411 aptamer and de…
  • The auxiliary ESCRT complexes provide robustness to cold in poikilothermic organisms. [Journal Article]
    Biol Open 2019Bäumers M, Klose S, … Klein T
  • The ESCRT pathway, comprising the in sequence acting ESCRT-0, -I, -II, -III and Vps4 complexes, conducts the abscission of membranes away from the cytosol. Whereas the components of the central ESCRT-III core complex have been thoroughly investigated, the function of the components of the associated two auxiliary ESCRT sub-complexes are not well-understood in metazoans, especially at the organism…
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