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821 results
  • Metabolic adaptation of airway smooth muscle cells to a SPHK2 substrate precedes cytostasis. [Journal Article]
    Am J Respir Cell Mol Biol 2019Blais-Lecours P, Laouafa S, … Marsolais D
  • Thickening of the airway smooth muscle is central to bronchial hyperreactivity. We have shown that the sphingosine analog AAL-R can reverse pre-established airway hyperreactivity in a chronic asthma model. Since sphingosine analogs can be metabolized by sphingosine kinase 2, we investigated whether this enzyme was required for AAL-R to perturb mechanisms sustaining airway smooth muscle cell proli…
  • Mutagenic and cytostatic activities of the Xylopia laevigata essential oil in human lymphocytes. [Journal Article]
    Nat Prod Res 2019; :1-4Pereira TS, Machado Esquissato GN, … Castro-Prado MAA
  • Hydro-distilled essential oil from leaves of Xylopia laevigata was characterized by GC-MS. Twenty-seven components were identified and the oil's major constituents comprised germacrene D, bicyclogermacrene, (E)-caryophyllene and germacrene B. The cytotoxicity of the essential oil of X. laevigata (EOXL), determined by MTT and mitotic index methods in cultured human lymphocytes was observed in all …
  • TGF-β-Mediated Epithelial-Mesenchymal Transition and Cancer Metastasis. [Review]
    Int J Mol Sci 2019; 20(11)Hao Y, Baker D, Ten Dijke P
  • Transforming growth factor β (TGF-β) is a secreted cytokine that regulates cell proliferation, migration, and the differentiation of a plethora of different cell types. Consistent with these findings, TGF-β plays a key role in controlling embryogenic development, inflammation, and tissue repair, as well as in maintaining adult tissue homeostasis. TGF-β elicits a broad range of context-dependent c…
  • An HK2 Antisense Oligonucleotide Induces Synthetic Lethality in HK1-HK2+ Multiple Myeloma. [Journal Article]
    Cancer Res 2019; 79(10):2748-2760Xu S, Zhou T, … Herschman HR
  • Although the majority of adult tissues express only hexokinase 1 (HK1) for glycolysis, most cancers express hexokinase 2 (HK2) and many coexpress HK1 and HK2. In contrast to HK1+HK2+ cancers, HK1-HK2+ cancer subsets are sensitive to cytostasis induced by HK2shRNA knockdown and are also sensitive to synthetic lethality in response to the combination of HK2shRNA knockdown, an oxidative phosphorylat…
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