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637 results
  • How Do We Treat Pregnancy-Related Venous Thromboembolism? [Journal Article]
    Hamostaseologie 2019Linnemann B, Seelbach-Goebel B, … Hart C
  • Venous thromboembolism (VTE) is a major cause of maternal morbidity and mortality during pregnancy and the postpartum period. Due to a lack of adequate study data, therapeutic strategies for pregnancy-related VTE are deduced from observational studies and extrapolated from recommendations for nonpregnant patients. Because heparins do not cross the placenta, weight-adjusted therapeutic-dose low-mo…
  • Heparin-induced Thrombocytopenia in Pediatrics Following Cardiopulmonary Bypass. [Journal Article]
    J Coll Physicians Surg Pak 2019; 29(10):986-992Yuan SM
  • Heparin-induced thrombocytopenia (HIT) is an immune-mediated response to heparin administration. HIT following cardiopulmonary bypass (CPB) procedures has not been clearly delineated in pediatric populations. By comprehensive retrieval of the pertinent literature published since 2000, 19 reports were collected with 33 pediatric patients recruited into this study. A female predominance was noted i…
  • Potential Role of Direct Oral Anticoagulants in the Management of Heparin-induced Thrombocytopenia. [Review]
    Pharmacotherapy 2019; 39(8):837-853Barlow A, Barlow B, … Harris J
  • Heparin-induced thrombocytopenia (HIT) is a rare, potentially life-threatening condition secondary to unfractionated heparin or low molecular weight heparin exposure. This immune-mediated drug reaction manifests as thrombocytopenia with a paradoxical hypercoagulable state that can result in life-threatening thrombosis. It is imperative to ensure cessation of heparin-based products as soon as HIT …
  • Heparinoids Danaparoid and Sulodexide as clinically used drugs. [Journal Article]
    Prog Mol Biol Transl Sci 2019; 163:55-74Dou H, Song A, … Zhang L
  • Heparin is the first glycosaminoglycan ever identified. All the heparin-like glycosaminoglycans that are also isolated from animal tissues or any polysaccharides that mimic the biological activities of heparin are called heparinoids. Heparin is the mostly sulfated glycosaminoglycan made by mast cells and an essential anticoagulant drug in modern medicine. Heparin inhibits both thrombin generation…
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