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3,068 results
  • Dynamic changes in RFRP3/GPR147 in the precocious puberty model female rats. [Journal Article]
    Curr Mol Med 2019Sun W, Li S, … Wang Y
  • To explore the role of RFamide related peptide 3/G protein coupled receptor 147 (RFRP3/GPR147) in the pathogenesis of precocious puberty based on a female rat model. The Sprague-Dawley female rats were randomly divided into three groups: normal, vehicle, and precocious puberty model. At 5 days old, the rat model with precocious puberty was established by subcutaneously injecting a mixture of dana…
  • Cyclical progestogens for heavy menstrual bleeding. [Review]
    Cochrane Database Syst Rev 2019; 8:CD001016Bofill Rodriguez M, Lethaby A, … Cameron IT
  • CONCLUSIONS: Low- or very low-quality evidence suggests that short-course progestogen was inferior to other medical therapy, including tranexamic acid, danazol and the Pg-IUS with respect to reduction of menstrual blood loss. Long cycle progestogen therapy (medroxyprogesterone acetate or norethisterone) was also inferior to the LNG-IUS, tranexamic acid and ormeloxifene, but may be similar to the combined vaginal ring with respect to reduction of menstrual blood loss.
  • Analysis of medication data of women with uterine fibroids based on data mining technology. [Journal Article]
    J Infect Public Health 2019Xuan J, Deng G, … Zheng Y
  • The purpose of this study was to analyze the characteristics of the diagnosis and treatment of female uterine fibroids based on data mining technology and the medication rule. Clinical literature related to the treatment of uterine fibroids by Chinese National Knowledge Infrastructure (CNKI) from 2004 to 2018 were searched, and the literature meeting the requirements were selected according to th…
  • Danazol mediates collateral sensitivity via STAT3/Myc related pathway in multidrug-resistant cancer cells. [Journal Article]
    Sci Rep 2019; 9(1):11628Chang YT, Teng YN, … Hung CC
  • Multidrug resistance presents an obstacle in cancer treatment. Among numerous combative strategies, collateral sensitivity (CS) drugs have opened a new avenue to defeat cancer by exploiting selective toxicity against multidrug-resistant (MDR) cancer. In the present study, a clinically used synthetic steroid hormone, danazol, was investigated for its CS properties and cytotoxic mechanisms. Compare…
  • Danazol: An Effective and Underutilised Treatment Option in Diamond-Blackfan Anaemia. [Case Reports]
    Case Rep Hematol 2019; 2019:4684156Chai KY, Quijano CJ, Chiruka S
  • Diamond-Blackfan anaemia (DBA) is a rare congenital red cell aplasia that presents in infancy. The exact molecular mechanism of ineffective erythropoiesis and red cell aplasia remains unclear, rendering targeted therapy elusive. The mainstay treatment of DBA is with regular blood transfusion and long-term corticosteroids, both of which have long-term side effects. We report a case of DBA successf…
  • Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus. [Journal Article]
    J Endocrinol 2019Simitsidellis I, Esnal Zufiaurre A, … Saunders PT
  • Selective androgen receptor modulators (SARMs) have been proposed as therapeutics for women suffering from breast cancer, muscle wasting or urinary incontinence. The androgen receptor (AR) is expressed in the uterus but the impact of SARMs on the function of this organ is unknown. We used a mouse model to compare the impact of SARMs (GTx-007/Andarine, GTx-024/Enobosarm), Danazol (a synthetic andr…
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