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4,797,458 results
  • Comparison of the MGISEQ-2000 and Illumina HiSeq 4000 sequencing platforms for RNA sequencing. [Journal Article]
    Genomics Inform 2019; 17(3):e32Jeon SA, Park JL, … Kim SY
  • Currently, Illumina sequencers are the globally leading sequencing platform in the next-generation sequencing market. Recently, MGI Tech launched a series of new sequencers, including the MGISEQ-2000, which promise to deliver high-quality sequencing data faster and at lower prices than Illumina's sequencers. In this study, we compared the performance of two major sequencers (MGISEQ-2000 and HiSeq…
  • Deep learning for stage prediction in neuroblastoma using gene expression data. [Journal Article]
    Genomics Inform 2019; 17(3):e30Park A, Nam S
  • Neuroblastoma is a major cause of cancer death in early childhood, and its timely and correct diagnosis is critical. Gene expression datasets have recently been considered as a powerful tool for cancer diagnosis and subtype classification. However, no attempts have yet been made to apply deep learning using gene expression to neuroblastoma classification, although deep learning has been applied t…
  • Optimization of a microarray for fission yeast. [Journal Article]
    Genomics Inform 2019; 17(3):e28Kim DU, Lee M, … Hoe KL
  • Bar-code (tag) microarrays of yeast gene-deletion collections facilitate the systematic identification of genes required for growth in any condition of interest. Anti-sense strands of amplified bar-codes hybridize with ~10,000 (5,000 each for up- and down-tags) different kinds of sense-strand probes on an array. In this study, we optimized the hybridization processes of an array for fission yeast…
  • FusionScan: accurate prediction of fusion genes from RNA-Seq data. [Journal Article]
    Genomics Inform 2019; 17(3):e26Kim P, Jang YE, Lee S
  • Identification of fusion gene is of prominent importance in cancer research field because of their potential as carcinogenic drivers. RNA sequencing (RNA-Seq) data have been the most useful source for identification of fusion transcripts. Although a number of algorithms have been developed thus far, most programs produce too many false-positives, thus making experimental confirmation almost impos…
  • Identification of neoantigens derived from alternative splicing and RNA modification. [Journal Article]
    Genomics Inform 2019; 17(3):e23Park J, Chung YJ
  • The acquisition of somatic mutations is the most common event in cancer. Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific. Since the immune system recognizes tumor-specific peptides, they are potential targets for personalized neoantigen-based immunotherapy. However, the discovery of druggable neoantigens remains challenging, suggesting that a d…
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